Improving Awakening Prognostication After Non Anoxic Coma Using PET-MRI in Intensive Care Unit

NACompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

February 16, 2017

Primary Completion Date

June 4, 2020

Study Completion Date

June 4, 2020

Conditions
Coma
Interventions
RADIATION

PET-MRI

18Fluoro-Desoxy-Glucose's infusion for PET (glucose neural metabolism assessment, with quantitative information permitted by radioactivity monitoring through arterial catheter ; dosage = 1,5 MBq/Kg + 18,5 MBq as loading dose 5 min= Outside the scanner, Installation and movement management: Curare+/- sedative injection with standardized routine care protocol 10 min= Outside the scanner, Starting PET continuous acquisitionT= 0, Morphological MRI sequences- 3DT1, 3DFlair, T2SE, T2 HR on brainstem, Susceptibility and simple Diffusion Weighted Imaging-Specifically dedicated MR sequences based upon clinical issues 25 min, MRI in Resting state N°1 (global short-term functional connectivity)13 min, MRI DTI acquisition, 64 directions, sensitive to white matter injury 8 min, IRM in 2D-Arterial Spin Labelling:Quantitative Cerebral blood flow information (no Gadolinium)-\>8 min, IRM in Resting state 2 (repeated occurrence to assess stationarity) 13 min, End of PET continuous acquisition

Trial Locations (1)

69500

Réanimation polyvalente neurologique Hôpital Neurologique HCL, Bron

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT02798588 - Improving Awakening Prognostication After Non Anoxic Coma Using PET-MRI in Intensive Care Unit | Biotech Hunter | Biotech Hunter