Reward Systems and Food Avoidance in Eating Disorders

NACompletedINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

November 30, 2016

Primary Completion Date

July 29, 2021

Study Completion Date

July 29, 2021

Conditions
Low Weight Eating DisordersAnorexia Nervosa
Interventions
BEHAVIORAL

Interoceptive Exposure (IE)

Participants are provided with a meal replacement shake of 'unknown' Kcal or macronutrient content and are asked to mindfully observe the sensations (aversive taste, texture, bloating, icky feeling, etc.) and associated emotional states (i.e., disgust) with the empathetic support of parents/therapist in session, without expectation of habituation. Sessions occur on a weekly basis with session one lasting 2 hrs. The remaining 5 sessions last one hour, and participants eat a meal replacement shake over 30-minutes, identical to the first session. All sessions include debriefing and development of IE homework that includes daily practice of IE.

BEHAVIORAL

Family Based Therapy-Weight Gain Control (FBT-WG)

Participants and families randomized to FBT-WG will receive 6-weeks of FBT treatment for AN. Sessions occur weekly, with the first session lasting two hours and the remaining 5 sessions one hour. FBT is atheoretical in terms of the etiology, but uses parent-enforced contingencies to increase value of eating and decrease the value of food avoidance.

DIETARY_SUPPLEMENT

meal replacement shake

Trial Locations (1)

10029

Icahn School of Medicine at Mount Sinai, New York

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Icahn School of Medicine at Mount Sinai

OTHER

NCT02795455 - Reward Systems and Food Avoidance in Eating Disorders | Biotech Hunter | Biotech Hunter