121
Participants
Start Date
January 31, 2017
Primary Completion Date
July 31, 2020
Study Completion Date
July 31, 2020
Ultrasound Scan
The research exam is expected to take 30 minutes for blood flow assessments
MRI Scan
MR imaging will take approximately 30 minutes.
Ferumoxytol
A subset of subjects will complete MRI imaging with ferumoxytol as a contrast agent at the 24-28 week visit. A nurse will administer ferumoxytol in a hospital triage with pulse and blood pressure monitoring and fetal heart monitoring. The pharmacy will prepare the infusion and deliver to triage. Subjects will arrive at the obstetric triage unit for ferumoxytol injection three days prior to their scheduled ferumoxytol MRI study. In the triage, the nurse will obtain baseline vital signs and fetal heart rate. The IV Ferumoxytol infusion will be 30 minutes and atients will be monitored at 5 to 15-minute intervals. Three days after the ferumoxytol infusion, at 24-26 weeks gestation, subjects will have blood/urine collected, undergo a 30 minute ultrasound, a 30 minute MRI, an adverse event review, and medical record review. The MRI scanning procedure will be conducted at WIMR and will last approximately 30-60 minutes.
UnityPoint Health-Meriter Hospital, Madison
University of Wisconsin-Hospitals and Clinics, Madison
National Institutes of Health (NIH)
NIH
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
University of Wisconsin, Madison
OTHER