APixaban vs. PhenpRocoumon in Patients With ACS and AF: APPROACH-ACS-AF

PHASE4CompletedINTERVENTIONAL
Enrollment

403

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

August 31, 2020

Study Completion Date

August 31, 2020

Conditions
Acute Coronary SyndromeAtrial FibrillationCoronary Artery Disease
Interventions
OTHER

Dual Therapy

Combination of Apixaban 5mg/dl (or in reduced dosing of 2.5 mg/d depending on age, renal function and body weight) in combination with Clopidogrel 75 mg/d for 6 months.

OTHER

Triple Therapy

"HAS-BLED-Score \<3:~Combination of Phrenprocoumon (INR 2.0-2.5), Clopidogrel (75mg/d) and ASA (100 mg/d) for 6 months.~HAS-BLED-Score ≥ 3:~Combination of Phrenprocoumon (INR 2.0-2.5), Clopidogrel (75mg/d) and ASA (100 mg/d) for 1 month followed by Phrenprocoumon (INR 2.0-3.0) and Clopidogrel (75mg/d) for 5 months."

Trial Locations (16)

81377

Munich University Hospital, Munich

Unknown

Universitätsklinikum der RWTH Aachen, Aachen

Charité, Campus Benjamin Franklin, Berlin

Charité, Campus Virchow-Klinikum, Berlin

Klinikum Coburg, Coburg

Westdeutsches Herzzentrum am Universitätsklinikum, Essen

Universitätsmedizin Göttingen, Göttingen

Universitätsmedizin Greifswald, Greifswald

Universitätsklinikum Heidelberg, Heidelberg

UKHS Campus Kiel, Kiel

Klinikum Lüdenscheid, Lüdenscheid

Universitätsmedizin Mainz, Mainz

Universitätsklinikum Mannheim, Mannheim

Klinikum Augustinum, München

Städtisches Klinikum München-Neuperlach, München

Universitätsmedizin Rostock, Rostock

All Listed Sponsors
collaborator

Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

OTHER

collaborator

Technical University of Munich

OTHER

collaborator

Helmholtz Zentrum München

INDUSTRY

collaborator

University of Göttingen

OTHER

collaborator

University of München

OTHER

collaborator

University Medicine Greifswald

OTHER

lead

LMU Klinikum

OTHER

NCT02789917 - APixaban vs. PhenpRocoumon in Patients With ACS and AF: APPROACH-ACS-AF | Biotech Hunter | Biotech Hunter