NCT02789527View on ClinicalTrials.gov

Human Genomic Population Structure and Phenotype-genotype Variation in ADME Genes in Four Populations

NACompletedINTERVENTIONAL
Enrollment

367

Participants

Timeline

Start Date

November 30, 2015

Primary Completion Date

April 30, 2017

Study Completion Date

April 30, 2017

Conditions
Healthy
Interventions
DRUG

Phenotyping

finger-tip blood drop : enzymatic activities assessed by specific single point concentration ratios after oral intake of the Geneva micrococktail made of : CYP1A2: paraxanthine/caffeine CYP2B6: 4-hydroxybupropion/bupropion CYP2C9: 4-hydroxyflurbiprofen/flurbiprofen CYP2C19: 5-hydroxyomeprazole/omeprazole CYP2D6: dextrorphan/dextromethorphan CYP3A4: 1-hydroxymidazolam/midazolam

GENETIC

Genotyping

DNA sampling from a saliva sample

Trial Locations (4)

68100

Democritus University of Thrace/School of Health Sciences/University Campus, Dragana, Alexandroupoli

128 43

Charles University in Prague/Faculty of Science/Department of Anthropology and Human Genetics, Prague

P.O.Box 9086

Addis Ababa University/College of Health Sciences, Addis Ababa

P. O. Box 50

Sultan Qaboos University/College of Medicine and Health Sciences/Department of Pharmacology, Muscat

All Listed Sponsors
collaborator

Swiss National Science Foundation

OTHER

lead

Estella S. Poloni

OTHER

NCT02789527 - Human Genomic Population Structure and Phenotype-genotype Variation in ADME Genes in Four Populations | Biotech Hunter | Biotech Hunter