The Treatment of Hepatocirrhosis and Portal Hypertension

NACompletedINTERVENTIONAL
Enrollment

108

Participants

Timeline

Start Date

February 29, 2016

Primary Completion Date

December 31, 2019

Study Completion Date

January 31, 2020

Conditions
Hepatic CirrhosisPortal Hypertension
Interventions
PROCEDURE

Endoscopic therapy+ beta blockers

Endoscopic variceal ligation (EVL) is for the secondary prophylaxis of esophageal variceal hemorrhage,and Cyanoacrylate injection is for gastric varices (GV).A standard dose of NSBB (propranolol) was applied to patients according to the Baveno VI recommendations if there were no contraindications.

PROCEDURE

Endoscopic therapy+ PSE+beta blockers

Endoscopic variceal ligation (EVL) is for the secondary prophylaxis of esophageal variceal hemorrhage,and Cyanoacrylate injection is for gastric varices (GV).A standard dose of NSBB (propranolol) was applied to patients according to the Baveno VI recommendations if there were no contraindications.Partial splenic embolization (PSE) is one of the intra-arterial therapeutic approaches to embolize 60-80% splenic blood flow.

PROCEDURE

beta blockers

A standard dose of NSBB (propranolol) was applied to the primary prevention patients according to the Baveno VI recommendations if there were no contraindications.

PROCEDURE

Endoscopic therapy

Endoscopic variceal ligation (EVL) is for the primary prophylaxis of esophageal variceal hemorrhage,and Cyanoacrylate injection is for gastric varices (GV).

PROCEDURE

Endoscopic therapy+ PSE

Endoscopic variceal ligation (EVL) is for the primary prophylaxis of esophageal variceal hemorrhage,and Cyanoacrylate injection is for gastric varices (GV).Partial splenic embolization (PSE) is one of the intra-arterial therapeutic approaches to embolize 60-80% splenic blood flow.

PROCEDURE

Somatostatin+Endoscopic therapy

The first dose of 250 was injected intravenously, followed by a continuous iv infusion of 250 for 3-5 days. Endoscopic variceal ligation (EVL) is for the acute bleeding of esophageal variceal hemorrhage,and Cyanoacrylate injection is for gastric varices (GV).

PROCEDURE

Somatostatin+Endoscopic therapy+PSE

The first dose of 250 was injected intravenously, followed by a continuous iv infusion of 250 for 3-5 days. Endoscopic variceal ligation (EVL) is for the acute bleeding of esophageal variceal hemorrhage,and Cyanoacrylate injection is for gastric varices (GV).Partial splenic embolization (PSE) is one of the intra-arterial therapeutic approaches to embolize 60-80% splenic blood flow.

Trial Locations (1)

250012

Department of Gastroenterology,Qilu Hospital,Shandong University, Jinan

All Listed Sponsors
collaborator

Shandong Provincial Hospital

OTHER_GOV

collaborator

Jinan Military General Hospital

OTHER

lead

Yanjing Gao

OTHER

NCT02778425 - The Treatment of Hepatocirrhosis and Portal Hypertension | Biotech Hunter | Biotech Hunter