Cisplatin, Intensity-Modulated Radiation Therapy, and Pembrolizumab in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma

PHASE1CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

November 28, 2016

Primary Completion Date

December 3, 2018

Study Completion Date

May 20, 2022

Conditions
Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7Stage IVB Laryngeal Squamous Cell Carcinoma AJCC v7Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions
DRUG

Cisplatin

Given IV

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

OTHER

Laboratory Biomarker Analysis

Correlative studies

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (69)

10467

Montefiore Medical Center - Moses Campus, The Bronx

15232

UPMC-Shadyside Hospital, Pittsburgh

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

19111

Fox Chase Cancer Center, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Helen F Graham Cancer Center, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

30303

Grady Health System, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

32610

University of Florida Health Science Center - Gainesville, Gainesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

Cleveland Clinic Foundation, Cleveland

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44870

North Coast Cancer Care, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

46237

Franciscan Health Indianapolis, Indianapolis

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48202

Henry Ford Hospital, Detroit

50309

Iowa Methodist Medical Center, Des Moines

55905

Mayo Clinic in Rochester, Rochester

56601

Sanford Joe Lueken Cancer Center, Bemidji

58122

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

60504

Rush - Copley Medical Center, Aurora

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61801

Carle Cancer Center, Urbana

62526

Decatur Memorial Hospital, Decatur

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64131

The University of Kansas Cancer Center-South, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

68114

Nebraska Methodist Hospital, Omaha

70121

Ochsner Medical Center Jefferson, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

78229

University of Texas Health Science Center at San Antonio, San Antonio

80045

University of Colorado Hospital, Aurora

80524

Poudre Valley Hospital, Fort Collins

80907

Penrose-Saint Francis Healthcare, Colorado Springs

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85719

Banner University Medical Center - Tucson, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

90048

Cedars Sinai Medical Center, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

95816

Sutter Medical Center Sacramento, Sacramento

97015

Clackamas Radiation Oncology Center, Clackamas

97213

Providence Portland Medical Center, Portland

98195

University of Washington Medical Center - Montlake, Seattle

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

06520

Yale University, New Haven

03756

Dartmouth Hitchcock Medical Center, Lebanon

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH