Pilot Study of the Effect of Trastuzumab and GM-CSF on Children with Recurrent Ependymoma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

June 12, 2017

Primary Completion Date

February 27, 2025

Study Completion Date

March 31, 2026

Conditions
Posterior Fossa Ependymoma (PFEPN)
Interventions
DRUG

Trastuzumab after SubQ GM-CSF

Administration of trastuzumab following subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). Trastuzumab is a monoclonal antibody targeting HER2-positive cancers, commonly used in breast and gastric cancer treatment.

DRUG

Trastuzumab in combination with SubQ GM-CSF

Combine trastuzumab, a monoclonal antibody targeting HER2-positive cancers, with subcutaneous granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF functions as an immune system modulator, promoting the activation and proliferation of dendritic cells, macrophages, and granulocytes.

Trial Locations (1)

80045

Children's Hospital Colorado, Aurora

All Listed Sponsors
collaborator

Children's Hospital Colorado

OTHER

lead

University of Colorado, Denver

OTHER