High Dose Cytarabine Followed by Pembrolizumab in Relapsed/Refractory AML

PHASE2CompletedINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

August 22, 2016

Primary Completion Date

November 27, 2019

Study Completion Date

June 20, 2024

Conditions
Acute Myeloid Leukemia, in Relapse
Interventions
DRUG

pembrolizumab,

Pembrolizumab 200 mg is administered IV once as monotherapy, 14 days after the initiation of HiDAC salvage induction chemotherapy. Patients who have a response (i.e., PR/CR/CRi) to induction phase will receive maintenance pembrolizumab at 200 mg IV every 3 weeks for up to 2 years of maintenance therapy (i.e., beginning on day 1 of maintenance).

Trial Locations (2)

21205

Johns Hopkins School of Medicine The Sidney Kimmel Comprehensive Cancer Center, Baltimore

27599-7295

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

UNC Lineberger Comprehensive Cancer Center

OTHER

NCT02768792 - High Dose Cytarabine Followed by Pembrolizumab in Relapsed/Refractory AML | Biotech Hunter | Biotech Hunter