The MOTS (Medication Overuse Treatment Strategy) Trial

NACompletedINTERVENTIONAL
Enrollment

720

Participants

Timeline

Start Date

January 9, 2017

Primary Completion Date

March 31, 2021

Study Completion Date

March 31, 2021

Conditions
Migraine
Interventions
OTHER

Migraine Prophylactic Therapy Only

Start of new migraine preventive therapy or adjustment of current preventive therapy without immediate discontinuation of the overused medication(s)

OTHER

Discontinuation of Overused Medication

Immediate discontinuation of the overused medication(s) and the start of new migraine preventive therapy or adjustment of current preventive therapy

Trial Locations (29)

15236

Preferred Headache Center, Pittsburgh

19107

Thomas Jefferson University Hospital Headache Center, Philadelphia

26506

West Virginia University Neurology, Morgantown

33021

Memorial Healthcare, Hollywood

33136

University of Miami Miller School of Medicine, Miami

39157

The Headache Center, Ridgeland

40207

Norton Neurology, Louisville

43623

Toledo Clinic Adult Neurology, Toledo

44195

Cleveland Clinic, Cleveland

45417

University of Cincinnati Neurology, Cincinnati

University of Cincinnati Headache Center, Dayton

49201

Henry Ford Allegiance Health, Jackson

55905

Mayo Clinic Headache Center, Rochester

65801

Clinvest Research, Springfield

80045

University of Colorado Denver Headache Center, Aurora

80111

Blue Sky Neurology, Greenwood Village

80238

University of Colorado Denver Primary Center, Denver

84106

University of Utah Primary Care, Salt Lake City

84108

University of Utah General Neurology, Salt Lake City

84132

University of Utah Headache Center, Salt Lake City

85054

Mayo Clinic in Arizona Headache Center, Phoenix

Mayo Clinic in Arizona Neurology Center, Phoenix

85251

Honor Health Neurology, Scottsdale

85260

Mayo Clinic Thunderbird, Scottsdale

86001

Northern Arizona Healthcare Medical Group, Flagstaff

90033

Keck Medical Center of USC, Los Angeles

98195

University of Washington, Seattle

02130

Brigham Women's Hospital Headache Clinic, Boston

Brigham Women's Hospital Neurology Clinic, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Patient-Centered Outcomes Research Institute

OTHER

lead

Mayo Clinic

OTHER

NCT02764320 - The MOTS (Medication Overuse Treatment Strategy) Trial | Biotech Hunter | Biotech Hunter