503
Participants
Start Date
June 7, 2016
Primary Completion Date
April 24, 2018
Study Completion Date
July 7, 2022
Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody
Atezolizumab intravenous infusion was administered at a dose of 1200 mg on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4) and maintenance phase (Cycle 5 onward).
Carboplatin
Carboplatin intravenous infusion to achieve an initial target AUC of 5 mg/mL/min was administered on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4).
Etoposide
Etoposide intravenous infusion was administered at a dose of 100 mg/m\^2 on Days 1, 2, and 3 of each 21-day cycle during the induction phase (Cycles 1-4).
Placebo
Placebo intravenous infusion was administered on Day 1 of each 21-day cycle during the induction phase (Cycles 1-4) and maintenance phase (Cycle 5 onward).
National Taiwan Uni Hospital; Internal Medicine, Taipei
Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology, Taipei
Chang Gung Medical Foundation - Linkou; Chest Dept, Taoyuan District
Semmelweis Egyetem, AOK, Pulmonologiai Klinika, Budapest
Orszagos Koranyi TBC es Pulmonologiai Intezet, Budapest
Klinik Penzing; Abteilung für Atemwegs- und Lungenkrankheiten, Vienna
Krankenhaus Nord - Klinik Floridsdorf; Abteilung Pulmologie, Vienna
Tudogyogyintezet Torokbalint, Törökbálint
Chris O'Brien Lifehouse, Camperdown
Royal Melbourne Hospital; Hematology and Medical Oncology, Parkville
Kepler Universitätskliniken GmbH - Med Campus III; Abt. für Lungenkrankheiten, Linz
The Prince Charles Hospital; Oncology Dept., Chermside
Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika, Debrecen
Salzburger Landeskliniken; Universitätsklinik für Pneumologie/ Lungenheilkunde, Salzburg
Clinical Center of Serbia, Belgrade
Sotiria Chest Hospital of Athens, Athens
Broome Oncology - Binghamton, Binghamton
Hôpital Nord - AP-HM Marseille#, Marseille
Centre Francois Baclesse; Oncologie, Caen
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Irccs Istituto Europeo di Oncologia (IEO); Divisione di Oncologia, Milan
Weinberg CA Inst Franklin Sq, Baltimore
Virginia Cancer Specialists, PC, Fairfax
LungenClinic Großhansdorf GmbH, Großhansdorf
Blue Ridge Cancer Care, Roanoke
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid
Hospital Universitario La Paz; Servicio de Oncologia, Madrid
Levine Cancer Institute, Charlotte
Hospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia, Málaga
Northwest Georgia Oncology Centers PC - Marietta, Marietta
Florida Hospital, Orlando
Institut Bergonie; Oncologie, Bordeaux
Florida Cancer Specialists., St. Petersburg
Florida Cancer Specialists - Fort Myers (Broadway), Fort Myers
Fachklinik für Lungenerkrankungen, Immenhausen
Tennessee Oncology PLLC - Nashville (20th Ave), Nashville
Tennessee Oncology Chattanooga, Chattanooga
Louisville Oncology, Louisville
Hospital Universitario Virgen del Rocio; Servicio de Oncologia, Seville
A.O. Universitaria Di Parma, Parma
Hosp Clinico Univ Lozano Blesa; División De Oncología Médica, Zaragoza
University of Wisconsin, Madison
Mayo Clinic, Rochester
Azienda Ospedaliera Universitaria Pisana - Ospedale Cisanello; Dipartimento Cardio Toraco Vascolare, Pisa
Hopital Calmette; Pneumologie Oncologie Ouest, Lille
Cancer Treatment Centers of America - Midwestern Regional Medical Center, Zion
Illinois Cancer Care, Peoria
Thoraxklinik Heidelberg gGmbH, Heidelberg
IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia, San Giovanni Rotondo
Asklepios-Fachklinik Muenchen-Gauting; Klinik Für Pneumologie, Gauting
Comprehensive Cancer Centers of Nevada - Eastern Avenue, Las Vegas
Northwest Medical Specialties, Tacoma
Beijing Cancer Hospital, Beijing
N.N.Burdenko Main Military Clinical Hospital; Oncology Dept, Moscow
Russian Oncology Research Center n.a. N.N. Blokhin, Moscow
Jilin Cancer Hospital, Changchun
Moscow City Oncology Hospital #62, Moscovskaya Oblast
Harbin Medical University Cancer Hospital, Harbin
Scientific Research Oncology Institute named after N.N. Petrov; Oncology, Saint Petersburg
City Clinical Onc., Saint Petersburg
Zhongshan Hospital Fudan University, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Jiangsu Cancer Hospital, Nanjing
Zhejiang Cancer Hospital, Zhejiang
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
City Clinical Hospital No. 1, Novosibirsk
OrlandiOncología, Santiago
Bradford Hill Centro de Investigaciones Clinicas, Recoleta
Rush University Medical Center, Chicago
New England Cancer Specialists, Scarborough
The Valley Hospital, Paramus
Vanderbilt Medical Center, Nashville
Santa Casa de Misericordia de Salvador, Salvador
Hospital Bruno Born, Lajeado
Hospital das Clinicas - UFRGS, Porto Alegre
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice Na Bulovce, Prague
Thomayerova nemocnice, Praha 4 - Krc
Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin II, Halle
Agioi Anargyroi; 3Rd Dept. of Medical Oncology, Athens
University Hospital of Patras Medical Oncology, Pátrai
Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica, Rome
Kyushu University Hospital; Respiratory, Fukuoka
National Hospital Organization Himeji Medical Center, Hyōgo
Kanagawa Cancer Center;Thoracic Oncology, Kanagawa
University Hospital Kyoto Prefectural University of Medicine,?Pulmonary Medicine, Kyoto
Sendai Kousei Hospital; Pulmonary Medicine, Miyagi
Kurashiki Central Hospital; Respiratory Medicine, Okayama
Kindai University Hospital; Medical Oncology, Osaka
National Hospital Organization Kinki-Chuo Chest Medical Center; Internal Medicine, Osaka
Saitama Cancer Center; Thoracic Oncology, Satima
Shizuoka Cancer Center; Thoracic Oncology, Shizuoka
Tokyo Metropolitan Komagome Hospital; Thoracic Oncology and Respiratory Medicine, Tokyo
The Cancer Institute Hospital of JFCR, Respiratory Medicine, Tokyo
Wakayama Medical University Hospital; Respiratory Medicine and Medical Oncology, Wakayama
Health Pharma Professional Research, Mexico City
Medical University of Gdansk, Gdansk
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz
Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc; Oddzial V Chemioterapii Nowotworow Pluc, Olsztyn
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy, Otwock
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu, Poznan
Centrum Onkologii - Inst.Im. Marii Sklodowskiej-Curie; Oncology, Warsaw
Clinical Center Nis; Clinic for pulmonary diseases, Niš
Seoul National University Bundang Hospital, Seongnam-si
Seoul National University Hospital, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de la Barca
Royal Devon & Exeter Hospital; Oncology Centre, Exeter
Barts and the London NHS Trust., London
Guys and St Thomas NHS Foundation Trust, Guys Hospital, London
Christie Hospital Nhs Trust; Medical Oncology, Manchester
Hoffmann-La Roche
INDUSTRY