35
Participants
Start Date
September 23, 2016
Primary Completion Date
November 30, 2018
Study Completion Date
June 30, 2020
Olaparib
"Olaparib tablet dose will be dose-escalated on 4 dose levels , guided by a continual reassessment method (CRM).~One cycle will be 28 days (4 weeks) in duration, except for cycle 1 which will be 6 weeks."
metformin
From week 3 metformin will be gradually escalated from 500 mg/day to 1500 mg/day with weekly 500 mg dose escalation levels
metronomic cyclophosphamide
from week 2 Metronomic cyclophosphamide will be given continuously on an oral daily basis at 50 mg qd
Service d'Oncologie Médicale, Centre François Baclesse, Caen
Département de Cancérologie Cervico-Faciale et Thoracique, Centre Oscar Lambret, Lille
Centre Hospitalier Lyon Sud, Pierre-Bénite
Service d'Oncologie Médicale, Institut Curie, Paris
Comité Gynécologique, Institut Gustave Roussy, Villejuif
Département d'Oncologie Médicale, Centre Antoine Lacassagne, Nice
Hospices Civils de Lyon
OTHER