A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

1,253

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

April 28, 2020

Study Completion Date

May 12, 2021

Conditions
Colorectal Cancer
Interventions
DRUG

Napabucasin

Napabucasin 240 mg will be administered orally, twice daily, with doses separated by approximately 12 hours (480 mg total daily dose).

DRUG

Fluorouracil

DRUG

Leucovorin

DRUG

Irinotecan

DRUG

Bevacizumab

Trial Locations (211)

1050

CHU de Liège - Domaine Universitaire du Sart Tilman, Brussels

1070

Hôpital Erasme, Brussels

2010

St Vincent's Hospital, Darlinghurst

2031

Prince of Wales Hospital, Randwick

2065

Northern Cancer Institute, St Leonards

2200

Bankstown-Lidcombe Hospital, Bankstown

2300

AZ Turnhout - Campus Sint-Elisabeth, Turnhout

2444

Port Macquaries Base Hospital, Port Macquarie

2820

Imelda Ziekenhuis, Bonheiden

2821

Imelda Ziekenhuis, Bonheiden

2822

Imelda Ziekenhuis, Bonheiden

3000

UZ Leuven - Campus Gasthuisberg, Leuven

3021

Western Health, Melbourne

3065

St Vincent's hospital Melbourne, Fitzroy

3084

Austin Hospital, Heidelberg

3199

Peninsula & South Eastern Haematology and Oncology Group, Frankston

3203

Hospital General Universitario de Elche, Elche

3550

Bendigo Hospital, Bendigo

3630

Goulburn Valley Health, Shepparton

4215

Gold Coast University Hosptial, Southport

4560

Sunshine Coast Hospital and Health Service, Nambour

5011

The Queen Elizabeth Hospital, Woodville

5042

Flinders Medical Centre, Bedford Park

6000

Grand Hôpital de Charleroi - Site Notre-Dame, Charleroi

7198

Hospital Son Llatzer, Baleares

8000

AZ Sint-Jan Brugge - Oostende - Campus Sint-Jan, Bruges

8036

Hospital Clinic i Provincial de Barcelona, Barcelona

8310

AZ Sint-Lucas - Campus Sint-Lucas, Bruges

8916

Institut Català d'Oncologia-Hospital Universitari Germans Trias i Pujol, Badalona

10065

Weill Cornell Medical College, New York

10126

AOU Città della Salute e della Scienza di Torino - Molinette, Torino

10408

National Cancer Centre, Goyang

10467

Montefiore Medical Center, The Bronx

10967

Vivantes Klinikum Am Urban, Berlin

11733

North Shore Hematology Oncology Associates, East Setauket

12203

Charite - Campus Benjamin Franklin (Cbf), Berlin

12559

DRK Kliniken Berlin Koepenick, Berlin

13100

Ziv Medical Center (The Rebecca Sieff Hospital), Safed

13353

Charité Universitätsmedizin, Berlin

14195

MVZ Onkologischer Schwerpunkt am Oskar-Helene-Heim, Berlin

14263

Roswell Park Cancer Center, Buffalo

15006

Complexo Hospital Universitario A Coruña, A Coruña

15240

VA Pittsburgh Healthcare System, Pittsburgh

16132

AO S. Martino, IRCCS, IST, Genova

16499

Ajou University Hospital, Suwon

17822

Geisinger Medical Center, Danville

19713

Medical Oncology Hematology Consultants, PA, Newark

20141

Ieo, Irccs, Milan

20249

Facharztzentrum Eppendorf, Hamburg

21079

Centre de Lutte Contre le Cancer (CLCC), Dijon

21565

Gachon University Gil Medical Center, Incheon

22031

US Oncology - Virginia Cancer Specialists, PC, Fairfax

22060

Fort Belvoir Community Hospital, Fort Belvoir

22190

Hôpital Privé des Côtes d'Armor - Service oncologie, Plérin

22763

Asklepios Klinik Altona, Hamburg

23666

Virginia Oncology Associates, Hampton

24014

Blue Ridge Cancer Care, Roanoke

25030

Hospitalier Jean Minjoz, Besançon

26100

PO di Cremona, ASST di Cremona, Cremona

27157

Wake Forest Baptist Medical Center, Winston-Salem

27534

Southeastern Medical Oncology Center, Goldsboro

28016

Hospital Universitario Gregorio Marañón, Madrid

28040

Hospital Clínico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28222

Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda

28922

Hospital Universitario Fundacion Alcorcon (HUFA), Alcorcón

29121

Ospedale Guglielmo da Saliceto, AUSL Piacenza, Piacenza

29412

Medical University of South Carolina, Charleston

29609

Hôpital Morvan - CHRU de Brest - cancérologie et d'hématolog, Brest

30046

Suburban Hematology-Oncology Associates, PC - Lawrenceville, Lawrenceville

30120

Hospital Universitario Virgen de la Arrixaca, Murcia

30318

Piedmont Cancer Institute, PC, Atlanta

30322

Emory University/Winship Cancer Institute, Atlanta

32032

Ospedale Santa Maria del Prato, Feltre

33011

Hospital Universitario Central de Asturias, Oviedo

33021

Memorial Cancer Institute at Memorial Hospital, Hollywood

33176

Baptist Health Medical Group Oncology, LLC, Miami

33401

Palm Beach Cancer Institute, West Palm Beach

33705

Sarah Cannon Research Institution, St. Petersburg

33901

Florida Cancer Specialists & Research Institute Fort Myers, Fort Myers

35033

Universitätsklinikum Marburg, Marburg

35042

Centre Eugene Marquis, Rennes

35223

Alabama Oncology, Birmingham

37203

The Sarah Cannon Research Institute, Nashville

37920

University of Tennessee Medical Center, Knoxville

38138

West Cancer Center, Memphis

39104

Schwerpunkpraxis für Hämatologie und Onkologie, Magdeburg

40138

Policlinico S.Orsola Malpighi, AOU di Bologna, Bologna

41009

Hospital Universitario Virgen de la Macarena, Seville

41013

H.U.V. del Rocío, Seville

41124

AOU Policlinico di Modena, Modena

42415

Yeungnam University Medical Center, Daegu

43623

Toledo Clinic Cancer Centers, Toledo

44093

CHU de Nantes - Hopital Hotel Dieu, Nantes

44805

Centre Rene Gauducheau, Saint-Herblain

46010

H.C.U.Valencia, Valencia

46014

Consorci Hospital General Universitari Valencia (CHGUV), Comunidad Valenciana

46526

Indiana University Health Goshen Center for Cancer Care, Goshen

46545

Michiana Hematology Oncology, PC, Mishawaka

46845

Parkview Research Center, Fort Wayne

47014

Irccs Irst, Meldola

48018

AUSL della Romagna, Osp. degli Infermi, Faenza

49055

Centre Paul Papin, Angers

49100

Rabin MC - Oncology, Davidoff Center, Petah Tikva

50009

Hospital Universitario Miguel Servet, Zaragoza

52621

The Chaim Sheba Medical Centre - Division of Oncology, Tel Litwinsky

55404

Minnesota Oncology Hematology, P.A., Minneapolis

55905

Mayo Clinic Arizona, Rochester

57104

Sanford Cancer Center, Sioux Falls

60005

Illinois Cancer Specialists, Arlington Heights

60126

AOU Ospedali Riuniti Umberto I - GM.Lanc, Torrette Di Ancona

60201

Northshore University Healthsystem, Evanston

60487

Healthcare Research Network III, LLC, Tinley Park

60555

Northwestern Medicine Cancer Center, Warrenville

61231

Gesundheitszentrum Wetterau, Bad Nauheim

63003

CHU Estaing, Clermont-Ferrand

63131

Missouri Baptist Medical Center ACCRU Network Site, St Louis

64132

Research Medical Center, Kansas City

67214

Cancer Center of Kansas, Wichita

68106

Missouri Valley Cancer Consortium, Omaha

68118

Cancer Research Network of Nebraska / Oncology Associates PC, Omaha

Tennessee Oncology PLLC, Omaha

68803

Saint Francis Cancer Treatment Center, Grand Island

75015

Hôpital Européen Georges Pompidou - Digestive Oncology, Paris

75093

Texas Health Physicians Group, Plano

75203

Texas Oncology - Dallas Center, Dallas

75702

Texas Oncology - Tyler, Tyler

75705

Texas Oncology-Austin Midtown, Austin

76104

Texas Oncology - Fort Worth, Fort Worth

76210

Texas Oncology - Denton South, Denton

76310

Texas Oncology - Wichita Falls Texoma Cancer Center, Wichita Falls

77090

Millenium Oncology, Houston

78217

Texas Oncology-San Antonio, San Antonio

80131

"Università degli studi della Campania L.Vanvitelli", Napoli

80218

Rocky Mountain Cancer Centers, Denver

81501

St Mary's Hospital & Regional Med Center, Grand Junction

84403

Northern Utah Associates, Ogden

85054

Mayo Clinic Arizona, Phoenix

85771

Arizona Oncology Associates, PC - HOPE, Tucson

86021

Hospital of Poitiers, Poitiers

87131

University of New Mexico, Albuquerque

89081

Medizinische Universitaetsklin, Ulm

90017

Los Angeles Hematology Oncology Medical Group, Los Angeles

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90404

UCLA Hematology Oncology Santa Monica, Santa Monica

91010

City of Hope- Comprehensive Care Center, Duarte

91031

Shaare Zedek Medical center, Jerusalem

92093

University of California-San Diego/Moores UCSD Cancer Center, La Jolla

93309

Comprehensive Blood and Cancer Center, Bakersfield

95405

St. Joseph Heritage Healthcare, Santa Rosa

97422

Leopoldina Krankenhaus Med. Klinik 2, Schweinfurt

98101

Virginia Mason, Seattle

98684

Northwest Cancer Specialists, P.C., Vancouver

100142

Beijing Cancer Hospital, Beijing

119228

National University Cancer Institute, Singapore

150001

Pamela Youde Nethersole Eastern Hospital, Hong Kong

169610

National Cancer Centre, Singapore

188770

Raffles Hospital, Singapore

210029

Jiangsu Province Hospital, Jiangsu

450008

Henan Cancer Hospital, Henan

1834111

Ha'Emek Medical Center, Afula

4428164

Meir Medical Center, Kfar Saba

6423906

Tel Aviv Sourasky Medical Center - Oncology, Tel Aviv

7830604

The Barzilai Medical Center - Oncology Institute, Ashkelon

8410101

Soroka University Medical Center, Beersheba

02215

Dana Farber, Boston

01655

Umass Memorial Medical Center, Worcester

Unknown

University of Michigan Cancer Center, Ann Arbor

Queen Mary Hospital, Hong Kong

03756

Darthmouth-Hitchcock Medical Center, Lebanon

07962

Carol G. Simon Cancer Center, Morristown

98109-1023

Seattle Cancer Care Alliance, Seattle

T2N 4N2

Tom Baker Cancer Centre, Calgary

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

M4N 3M5

University of Toronto - Sunnybrook Health Sciences Centre, Toronto

M5B 1W8

Saint Michael's Hospital Li Ka Shing Knowledge Institute, Toronto

H3T 1M5

St. Mary's Hospital Center, Montreal

HZL 4M1

Hopital Notre-Dame du CHUM, Montreal

500 05

FN Hradec Kralove, Hradec Králové

625 00

Fakultni nemocnice Brno, Brno

656 53

Masarykuv onkologicky ustav, Brno

128 08

Vseobecna fakultni nemocnice v Praze, Prague

01307

Universitätsklinikum Carl Gustav Carus Dresden, Dresden

464-8681

Aichi Cancer Center Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsunami

060-8648

Hokkaido University Hospital, Sapporo

650-0047

Kobe City Medical Center General Hospital, Kobe

216-8511

ST. Marianna University School of Medicine, Kawasaki

565-0871

Osaka University Hospital, Suita

569-8686

Osaka Medical College Hospital, Takatsuki

362-0806

Saitama Cancer Center, Kita-Adachi

411-8777

Shizuoka Cancer Center, Sunto

113-8510

Medical Hospital, Tokyo Medical and Dental University, Bunkyo-ku

104-0045

National Cancer Center Hospital, Chuo-ku

135-8550

The cancer insitute hospital of JFCR (Japanese Foundation For Cancer Research), Koto-ku

811-1395

National Kyushu Cancer Center, Fukuoka

537-8511

Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

540-0006

National Hospital Organization Osaka National Hospital, Osaka

8934 AD

Medisch Centrum Leeuwarden, Leeuwarden

1055 AZ

Academisch Medisch Centrum, Amsterdam

2134 TM

Spaarne Gasthuis, Hoofddorp

6229 HX

Maastricht UMC, Maastricht

5042 SB

Elizabeth Tweesteden Ziekenhuis locatie Tilburg, Tilburg

02841

Korea University Anam Hospital, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

120-752

Severance Hospital, Yonsei University Health System, Seoul

080035

Hospital Universitario Vall d'Hebrón, Barcelona

08003

Hospital del Mar, Barcelona

All Listed Sponsors
lead

Sumitomo Pharma America, Inc.

INDUSTRY

NCT02753127 - A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer | Biotech Hunter | Biotech Hunter