The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

PHASE4CompletedINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 31, 2016

Primary Completion Date

December 31, 2021

Study Completion Date

December 31, 2021

Conditions
Severe Aplastic Anemia
Interventions
DRUG

Thymoglobulin

administration of ATG 3.5mg/kg/d (Thymoglobuline®, Genzyme) intravenously for 5 days

PROCEDURE

Cord blood

transfusion of one unit of at least 4/6 HLA loci matched cord blood.

DRUG

Cyclosporine Oral Product

administration of cyclosporine A 5mg/kg orally, and maintain the trough serum concentration between 200ng/ml to 300ng/ml.

Trial Locations (1)

200080

Shanghai general hospital, Shanghai Jiaotong university school of medicine, Shanghai

All Listed Sponsors
collaborator

Ruijin Hospital

OTHER

collaborator

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

collaborator

Shanghai Tongji Hospital, Tongji University School of Medicine

OTHER

collaborator

Zhejiang Provincial Hospital of TCM

OTHER

lead

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

NCT02745717 - The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia | Biotech Hunter | Biotech Hunter