20,000
Participants
Start Date
April 11, 2016
Primary Completion Date
February 28, 2026
Study Completion Date
February 29, 2028
Ceftriaxone
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Moxifloxacin or Levofloxacin
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Piperacillin-tazobactam
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Ceftaroline
"The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.~Note: this intervention is now closed."
Amoxicillin-clavulanate
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Standard course macrolide
"Standard course of macrolide therapy, discontinued between study day 3 and the end of study day 5.~The dosing of and route of administration is not protocolised, the following guidance is provided:~* Initial IV administration of a macrolide is strongly preferred~* The preferred IV macrolide is azithromycin, but IV clarithromycin may be substituted.~* The preferred enteral macrolide is azithromycin, but enteral clarithromycin or roxithromycin may be substituted."
Extended course macrolide
"Extended course of macrolide therapy discontinued at the end of study day 14 or hospital discharge (whichever occurs first).~The dosing of and route of administration is not protocolised, the following guidance is provided:~* Initial IV administration of a macrolide is strongly preferred~* The preferred IV macrolide is azithromycin, but IV clarithromycin may be substituted.~* The preferred enteral macrolide is azithromycin, but enteral clarithromycin or roxithromycin may be substituted."
No systemic corticosteroid
Patients are not to receive any systemic corticosteroids, including hydrocortisone, to study day 28 or hospital discharge (whichever occurs first).
Fixed-duration Hydrocortisone
"50mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days.~Note: this intervention is now closed."
Shock-dependent hydrocortisone
50mg IV hydrocortisone every 6 hours while the patient is in septic shock
Fixed-duration higher dose Hydrocortisone
"100mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days.~Note: this intervention was only available to patients with suspected or proven COVID-19 and is now closed."
No antiviral agent for influenza
No antiviral agent intended to be active against influenza infection is to be administered
Five-days oseltamivir
Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first)
Ten-days oseltamivir
Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first)
No antiviral agent for COVID-19
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered
Lopinavir / Ritonavir
"Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU.~Note: this intervention is now closed."
Hydroxychloroquine
"Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first).~Note: this intervention is now closed."
Hydroxychloroquine + lopinavir/ritonavir
"Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU.~Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first).~Note: this intervention is now closed."
Ivermectin
"Ivermectin administered enterally at a dose of 0.2 mg/kg once daily with a maximum daily dose of 24mg/day.~Note: this intervention is now closed."
No immune modulation for COVID-19
"No immune modulating agent intended to be active against COVID-19 is to be administered.~Note: this intervention is now closed."
Interferon beta-1a
"IFN-β1a 10 μg will be administered as an intravenous bolus injection via a central or peripheral line. IFN-β1a will be administered once daily for 6 days or until ICU discharge, whichever occurs first.~Note: this intervention is now closed."
Anakinra
"A loading dose of 300mg anakinra will be administered as a bolus via central or peripheral line. This is followed by maintenance doses of 100mg of anakinra administered every 6 hours.~In patients with renal impairment, anakinra will be administered on alternate days.~Note: this intervention is now closed."
Tocilizumab
"Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg.~Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period.~Note: this intervention is now closed."
Sarilumab
"Sarilumab will be administered as a single dose of 400mg, via IV infusion through peripheral or central line over a one-hour period.~Note: this intervention is now closed."
Local standard venous thromboprophylaxis
"Standard venous thromboprophylaxis that complies with local guidelines or usual practice will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
Therapeutic dose anticoagulation
"Patients will be administered either low molecular weight heparin (LMWH) or unfractionated heparin (UFH) to achieve systemic anticoagulation. Either agent may be used and the same patient may be switched between UFH and LMWH at the discretion of the treating clinician.~Note: this intervention is now closed."
Conventional low dose thromboprophylaxis
Low dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain.
Intermediate dose thromboprophylaxis
Intermediate dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain.
Continuation of therapeutic dose anticoagulation
"Patients already receiving therapeutic dose anticoagulation at the time of randomisation to this intervention will be administered either unfractionated heparin by IV infusion or low-molecular weight heparin to achieve systemic anticoagulation according to local practice for acute VTE treatment for 14 days following randomisation or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
No immunoglobulin
No immunoglobulin intended to be active against SARS-CoV-2 infection is to be administered.
Convalescent plasma
Patients will receive at least one and no more than two units of ABO compatible convalescent plasma within 48 hours of randomisation.
Delayed administration of convalescent plasma
Note: this intervention is now closed.
No vitamin C
"No high dose intravenous vitamin C is to be administered~Note: this intervention is now closed."
Vitamin C
"Intravenous Vitamin C 50mg/kg administered every 6 hours for 16 doses~Note: this intervention is now closed."
No antiplatelet
"No antiplatelet agent or NSAID to be administered.~Note: this intervention is now closed."
Aspirin
"Aspirin administered at either 75mg or 100mg once per day for 14 days or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
P2Y12 inhibitor
"Site-selected P2Y12 inhibitor:~* Clopidogrel: administered 75 mg once per day for 14 days or until hospital discharge, whichever occurs first.~* Prasugrel: If patient is aged less than 75 years and measured or estimated weight if 60kg or more, and initial loading dose of prasugrel 60 mg will be administered, followed by maintenance dose of 10 mg per day.~* Ticagrelor: administered enterally at 60mg twice daily for 14 days or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
No simvastatin
"No simvastatin intended to be active against COVID-19 is to be administered~Note: this intervention is now closed."
Simvastatin
"Simvastatin 80mg administered once daily via enteral route, while the patient remains in hospital up to 28 days after randomisation~Note: this intervention is now closed."
Eritoran
"Eritoran initiated with a 26.24 mg loading dose (6.56 mg/h IV for 4 hours), followed by a second 13.12 mg loading dose (6.56 mg/h IV for 2 hours) at 12 hours after initiation. Patients will then receive twenty-six 6.56 mg maintenance doses (3.28 mg/h IV for 2 hours) every 12 hours thereafter (total of 14 days). Dosing will be stopped if the patient is discharged from hospital~Note: this intervention is now closed."
Apremilast
"Apremilast administered 30mg twice daily for 14 days or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
Clinician-preferred mechanical ventilation strategy
Clinician-preferred ventilation strategy, including mode of ventilation and all ventilatory parameters
Protocolised mechanical ventilation strategy
Invasive mechanical ventilation strategy delivered as outlined in relevant protocol documents for this domain.
No renin-angiotensin system inhibitor
"No RAS inhibitor (i.e. no ACEi or ARB) is to be administered up to the end of study day 10.~Note: this intervention is now closed."
Angiotensin converting enzyme inhibitor
"Site-preferred ACEi agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
Angiotensin Receptor Blockers
"Site-preferred ARB agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first.~Note: this intervention is now closed."
ARB + DMX-200
"Site-preferred ARB agent administered in combination with DMX-200 for 10 days or until hospital discharge, whichever occurs first.~ARB administered as directed by the treating clinician. DMX-200 administered enterally at a dose of 120mg twice daily.~Note: this intervention is now closed."
No cysteamine
"No cysteamine to be administered until the end of study day 10 or hospital discharge, whichever occurs first.~Note: this intervention is now closed."
Cysteamine
"Cysteamine administered every 8 hours at a dose of 5 mg/kg estimated or measured body weight (maximum dose of 500mg), for ten days or until ICU discharge, whichever occurs first.~Note: this intervention is now closed."
Fixed-duration dexamethasone
6 mg of IV or enteral dexamethasone will be administered daily for up to 10 days while in hospital.
Baloxavir Marboxil
Baloxavir marboxil administered on days 1 and 4 post-randomisation.
Five-days oseltamivir + baloxavir marboxil
Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation.
Ten-days oseltamivir + baloxavir marboxil
Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation.
No endothelial modulator
No endothelial modulator (imatinib or another tyrosine kinase inhibitor targeting the same pathway as imatinib) is to be administered.
Imatinib
Enteral imatinib will be administered as a single 800mg loading dose (study day 1) followed by 400mg daily until study day 14 or discharge.
No Immune Modulator for Influenza
No immune modulating agent intended to be active against influenza is to be administered.
Tocilizumab
"Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. In children weighing less than 30kg, tocilizumab dose will be 12mg/kg.~Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period."
Baricitinib
Baricitinib will be administered at a dose that is determined by age and renal function, for up to 10 days or hospital discharge (whichever occurs first).
No antiviral agent for COVID-19
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered
Nirmatrelvir/ritonavir
Nirmatrelvir-ritonavir will be administered at a dose that is dependent on renal function, for five days.
Remdesivir
Remdesivir is administered at 200 mg on day one followed by 100 mg daily for a further four doses (i.e., for five doses in total) or until hospital discharge, whichever occurs first.
Nirmatrelvir/ritonavir + remdesivir
Nirmatrelvir-ritonavir will be administered at a dose that is dependent on renal function, for five days. Remdesivir is administered at 200 mg on day one followed by 100 mg daily for a further four doses (i.e., for five doses in total) or until hospital discharge, whichever occurs first.
RECRUITING
CVICU, Auckland City Hospital, Auckland
RECRUITING
DCCM, Auckland City Hospital, Auckland
RECRUITING
University Medical Centre Maribor, Maribor
RECRUITING
St Vincent's Hospital Sydney, Sydney
RECRUITING
Prince of Wales Hospital, Sydney
NOT_YET_RECRUITING
Royal Prince Alfred Hospital, Sydney
RECRUITING
Royal North Shore Hospital, Sydney
RECRUITING
Northern Beaches Hospital, Frenchs Forest
RECRUITING
Middlemore Hospital, Auckland
RECRUITING
Concord Hospital, Concord
RECRUITING
Westmead Hospital, Westmead
RECRUITING
Blacktown Hospital, Blacktown
RECRUITING
Liverpool Hospital, Liverpool
RECRUITING
Bankstown-Lidcombe Hospital, Bankstown
RECRUITING
St. George Hospital, Kogarah
RECRUITING
Sutherland Hospital, Caringbah
RECRUITING
John Hunter Hospital, Newcastle
RECRUITING
Wollongong Hospital, Sydney
RECRUITING
Campbelltown Hospital, Campbelltown
RECRUITING
Canberra Hospital, Canberra
NOT_YET_RECRUITING
Wagga Wagga Base Hospital, Wagga Wagga
RECRUITING
Nepean Hospital, Kingswood
NOT_YET_RECRUITING
Orange Health Service, Orange
RECRUITING
Dubbo Base Hospital, Dubbo
RECRUITING
The Alfred Hospital, Melbourne
RECRUITING
Rotorua Hospital, Rotorua
RECRUITING
Footscray Hospital, Footscray
RECRUITING
Sunshine Hospital, Sunshine
RECRUITING
Werribee Mercy Hospital, Werribee
RECRUITING
Royal Melbourne Hospital, Melbourne
RECRUITING
St Vincent's Hospital Melbourne, Melbourne
RECRUITING
Tauranga Hospital, Tauranga
RECRUITING
Box Hill Hospital, Box Hill
RECRUITING
Maroondah Hospital, Ringwood East
NOT_YET_RECRUITING
Angliss Hospital, Ferntree Gully
RECRUITING
Monash Medical Centre, Clayton
RECRUITING
Dandenong Hospital, Dandenong
RECRUITING
Waikato Hospital, Hamilton
RECRUITING
University Hosptial Geelong, Geelong
RECRUITING
Ballarat Base Hospital, Ballarat
RECRUITING
Bendigo Hospital, Bendigo
COMPLETED
Almási Balogh Pál Kórház, Ózd
RECRUITING
Casey Hospital, Berwick
NOT_YET_RECRUITING
Redcliffe Hospital, Redcliffe
RECRUITING
The Prince Charles Hospital, Brisbane
RECRUITING
Mater Hospital Brisbane, Brisbane
RECRUITING
Princess Alexandra Hospital, Brisbane
RECRUITING
Queen Elizabeth II Jubilee Hospital, Coopers Plains
NOT_YET_RECRUITING
Logan Hospital, Logan City
SUSPENDED
University Clinic of Respiratory and Allergic Diseases Golnik, Golnik
RECRUITING
Gold Coast University Hospital, Southport
RECRUITING
Taranaki Base Hospital, New Plymouth
RECRUITING
Toowoomba Hospital, Toowoomba
COMPLETED
Jósa András County Hospital, Nyíregyháza
RECRUITING
Caboolture Hospital, Caboolture
NOT_YET_RECRUITING
Sunshine Coast University Hospital, Birtinya
NOT_YET_RECRUITING
Rockhampton Hospital, Rockhampton
RECRUITING
Townsville Hospital, Townsville
RECRUITING
Royal Adelaide Hospital, Adelaide
RECRUITING
The Queen Elizabeth Hospital, Adelaide
RECRUITING
Flinders Medical Centre, Bedford Park
RECRUITING
Lyell McEwin Hospital, Adelaide
RECRUITING
CHU Namur site Godinne, Namur
RECRUITING
Royal Perth Hospital, Perth
RECRUITING
St John of God Subiaco, Subiaco
RECRUITING
Sir Charles Gairdner Hospital, Perth
RECRUITING
Wellington Regional Hospital, Wellington
RECRUITING
CHU de Charleroi - Hôpital Civil Marie Curie, Charleroi
RECRUITING
St John of God Hospital Midland, Midland
NOT_YET_RECRUITING
St John of God Hospital Murdoch, Murdoch
RECRUITING
Fiona Stanley Hospital, Perth
RECRUITING
Launceston Hospital, Launceston
RECRUITING
Christchurch Hospital, Christchurch
SUSPENDED
University Hospital Zürich, Zurich
RECRUITING
Universitair Ziekenhuis Gent, Ghent
RECRUITING
University Hospital Centre Zagreb, Zagreb
WITHDRAWN
University Hospital for Infectious Diseases, Zagreb
RECRUITING
Fakultní nemocnice Královské Vinohrady, Prague
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
WITHDRAWN
Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie, Berlin
SUSPENDED
University Clinical Centre of Serbia, Belgrade
SUSPENDED
University Hospital Center Dr Dragiša Mišović, Belgrade
RECRUITING
Hospital Universitario de Jerez, Cadiz
COMPLETED
Vivantes Klinikum Neukölln, Berlin
SUSPENDED
Charite Universitätsmedizin Berlin, Berlin
WITHDRAWN
Vivantes Humboldt-Klinikum, Berlin
RECRUITING
Reina Sofia University Hospital, Córdoba
RECRUITING
King Abdulaziz Medical City, Riyadh
COMPLETED
Centre Hospitalier Henri Mondor d'Aurillac, Aurillac
RECRUITING
Clinical Centre of Niš, Niš
RECRUITING
Humanitas Research Hospital, Milan
RECRUITING
Ca' Granda Ospedale Maggiore Policlinico, Milan
RECRUITING
IRCCS Ospedale San Raffaele, Milan
SUSPENDED
University Medical Center Hamburg-Eppendorf (UKE), Hamburg
RECRUITING
CHU Dijon Bourgogne, Dijon
RECRUITING
AO Spedali Civili di Brescia, Brescia
RECRUITING
Ramon y Cajal University Hospital, Madrid
RECRUITING
Hospital Regional de Málaga, Málaga
RECRUITING
Centre Hospitalier des Pays de Morlaix, Morlaix
NOT_YET_RECRUITING
Augusta University, Augusta
RECRUITING
Hospital Universitario de Ourense, Ourense
RECRUITING
University of Florida, Jacksonville
SUSPENDED
Tampere University Hospital, Tampere
RECRUITING
General County Hospital Požega, Požega
RECRUITING
CHRU Tours Hopital Bretonneau, Tours
RECRUITING
Hospital Marqués de Valdecilla, Santander
RECRUITING
Centre Hospitalier Layne - Mont-de-Marsan, Mont-de-Marsan
RECRUITING
CH de Dax, Dax
SUSPENDED
Teplice Hospital, Teplice
RECRUITING
Arcispedale S. Maria Nuova, Reggio Emilia
RECRUITING
The Ohio State University Wexner Medical Center, Columbus
RECRUITING
Hospital Verge de la Cinta, Tortosa
COMPLETED
Klinikum Dortmund, Dortmund
RECRUITING
Chitwan Medical College, Bharatpur
RECRUITING
Grande International Hospital, Kathmandu
RECRUITING
Hospital for Advanced Medicine and Surgery (HAMS), Kathmandu
RECRUITING
Nepal Mediciti, Kathmandu
ACTIVE_NOT_RECRUITING
CHR d'Orleans, Orléans
COMPLETED
Elisabeth Hospital Essen, Essen
RECRUITING
Doctor Peset University Hospital, Valencia
RECRUITING
Hospital La Fe, Valencia
NOT_YET_RECRUITING
Ospedale Infermi di Rimini, Rimini
RECRUITING
University of Michigan, Ann Arbor
SUSPENDED
Universitätsklinikum Münster, Münster
SUSPENDED
Tartu University Hospital, Tartu
WITHDRAWN
University Hospital of Cologne, Cologne
ACTIVE_NOT_RECRUITING
Beauvais General Hospital, Beauvais
WITHDRAWN
Universitätsklinikum Frankfurt, Frankfurt
RECRUITING
University of Illinois Health, Chicago
RECRUITING
Centre hospitalier Bethune Beuvry, Béthune
RECRUITING
Nouvel Hopital Civil Strasbourg, Strasbourg
ACTIVE_NOT_RECRUITING
Hopital de Hautepierre Strasbourg, Strasbourg
NOT_YET_RECRUITING
Tulane Medical Center, New Orleans
RECRUITING
Centre Hospitalier Le Mans, Le Mans
COMPLETED
Universitäts Klinikum Tübingen, Tübingen
RECRUITING
Ziauddin University Hospital Clifton Campus, Karachi
ACTIVE_NOT_RECRUITING
Lariboisiere Hospital, Paris
ACTIVE_NOT_RECRUITING
Hopital Tenon, Paris
RECRUITING
Abbasi Shaheed Hospital, Karachi
RECRUITING
National Institute of Cardiovascular Diseases, Karachi, Karachi
RECRUITING
South City Hospital, Karachi, Karachi
RECRUITING
Centre Hospitalier de Dieppe, Dieppe
ACTIVE_NOT_RECRUITING
Centre Hospitalier de Melun, Melun
SUSPENDED
Klinikum rechts der Isar der TU München, München
RECRUITING
CHD Vendee, La Roche-sur-Yon
RECRUITING
CHU Dupuytren, Limoges
RECRUITING
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo
RECRUITING
Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione, Palermo
SUSPENDED
Hopital Nord Franche-Comte, Belfort
ACTIVE_NOT_RECRUITING
Sud Essonne Hospital Etampes, Étampes
RECRUITING
Ambroise Pare Hospital, Boulogne-Billancourt
RECRUITING
Hospital Raymond Poincare, Garches
ACTIVE_NOT_RECRUITING
CH Argenteuil, Argenteuil
ACTIVE_NOT_RECRUITING
Hopital Simone Veil Eaubonne, Eaubonne
SUSPENDED
Universitätsklinikum Würzburg, Würzburg
ACTIVE_NOT_RECRUITING
Apollo Main Hospital, Chennai
RECRUITING
Apollo First Med Hospital, Chennai
ACTIVE_NOT_RECRUITING
Apollo Vanagaram Hospital, Chennai
RECRUITING
Apollo Speciality Hospital - OMR, Chennai
WITHDRAWN
The Baruch Padeh Medical Center, Poria – Neve Oved
WITHDRAWN
Rambam Medical Center, Haifa
SUSPENDED
Beilinson Hospital, Rabin Medical Center, Petah Tikva
NOT_YET_RECRUITING
Wake Forest Baptist Health, Winston-Salem
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
University of Pittsburgh Medical Centre, Pittsburgh
RECRUITING
Universidad de La Sabana, Chía
RECRUITING
Beaumont Hospital, Dublin
RECRUITING
St. Vincent's University Hospital, Dublin
RECRUITING
University Hospital Galway, Galway
RECRUITING
Jeroen Bosch Ziekenhuis, 's-Hertogenbosch
RECRUITING
Meander Medisch Centrum, Amersfoort
WITHDRAWN
Martini Hospital Groningen, Groningen
ACTIVE_NOT_RECRUITING
University Medical Center Groningen, Groningen
RECRUITING
Leiden University Medical Center, Leiden
RECRUITING
Canisius Wilhelmina Ziekenhuis, Nijmegen
RECRUITING
Radboud University Medical Center, Nijmegen
RECRUITING
Ziauddin University North Nazimabad Campus, Karachi
RECRUITING
Centro Hospitalar do Medio Tejo, Abrantes
SUSPENDED
Hospital Lusíadas Lisbon, Lisbon
RECRUITING
Hospital del Mar, Barcelona
NOT_YET_RECRUITING
Brown University - Rhode Island Hospital, Providence
NOT_YET_RECRUITING
Royal Darwin Hospital,, Darwin
ACTIVE_NOT_RECRUITING
Foothills Medical Centre, Calgary
ACTIVE_NOT_RECRUITING
Peter Lougheed Centre, Calgary
ACTIVE_NOT_RECRUITING
Rockyview General Hospital, Calgary
ACTIVE_NOT_RECRUITING
South Health Campus, Calgary
RECRUITING
Royal Alexandra Hospital, Alberta, Edmonton
RECRUITING
University of Alberta Hospital, Edmonton
NOT_YET_RECRUITING
Surrey Memorial Hospital, Surrey
RECRUITING
St Boniface General Hospital, Winnipeg
RECRUITING
Health Sciences Centre Winnipeg, Winnipeg
RECRUITING
Grace Hospital, Winnipeg
NOT_YET_RECRUITING
Dr. Everett Chalmers Regional Hospital, Fredericton
NOT_YET_RECRUITING
The Moncton Hospital, Fredericton
NOT_YET_RECRUITING
The Saint John General Hospital, Fredericton
RECRUITING
William Osler Health System, Brampton
RECRUITING
Brantford General Hospital, Brantford
RECRUITING
Hamilton general Hospital, Hamilton
RECRUITING
Juravinski Hospital, Hamilton
RECRUITING
St. Joseph's Healthcare Hamilton, Hamilton
ACTIVE_NOT_RECRUITING
Kingston Health Sciences Centre, Kingston
RECRUITING
Grand River Hospital, Kitchener
RECRUITING
St Mary's General Hospital, Kitchener
RECRUITING
The Ottawa Hospital, Ottawa
RECRUITING
Niagara Health, St. Catharines
ACTIVE_NOT_RECRUITING
Thunder Bay General Hospital, Thunder Bay
RECRUITING
Sunnybrook Health Sciences Centre, Toronto
RECRUITING
St. Michael's Hospital Unity Health Toronto, Toronto
RECRUITING
Mount Sinai Hospital, Toronto
RECRUITING
Toronto General Hospital, Toronto
RECRUITING
Toronto Western Hospital, Toronto
ACTIVE_NOT_RECRUITING
St Joseph's Health Centre, Toronto
NOT_YET_RECRUITING
CIUSS Chaudieres-Appalaches (Levis), Lévis
ACTIVE_NOT_RECRUITING
Hospital Maisonneuve-Rosemont, Montreal
NOT_YET_RECRUITING
Hôpital Fleury, Montreal
RECRUITING
Centre Hospitalier de l'Universite de Montreal, Montreal
RECRUITING
McGill University Health Centre, Montreal
RECRUITING
Hopital du Sacre-Coeur de Montreal, Montreal
RECRUITING
CHU de Québec - Université Laval, Québec
RECRUITING
IUCPQ-UL, Québec
RECRUITING
Centre Hospitalier de l'Université de Sherbrooke, Sherbrooke
RECRUITING
Regina General Hospital, Saskatoon
SUSPENDED
Helsinki University Hospital, Helsinki
COMPLETED
Carl-Thiem-Klinikum Cottbus, Cottbus
SUSPENDED
Universitätsklinikum Jena, Jena
SUSPENDED
University Hospital Leipzig, Leipzig
SUSPENDED
Universitätsklinikum Leipzig, Leipzig
ACTIVE_NOT_RECRUITING
Cork University Hospital, Cork
ACTIVE_NOT_RECRUITING
University Hospital Waterford, Waterford
RECRUITING
St Marianna University School of Medicine, Kawasaki
RECRUITING
Yokohama City University Hospital, Yokohama
RECRUITING
St. Marianna University Yokohama City Seibu Hospital, Yokohama
RECRUITING
Saiseikai Kumamoto Hospital, Minami
RECRUITING
Osaka City General Hospital, Osaka
RECRUITING
Nerima Hikarigaoka Hospital, Tokyo
RECRUITING
Tokyo Metropolitan Bokutoh Hospital, Tokyo
RECRUITING
Itabashi Chuo Medical Center, Tokyo
RECRUITING
Tokyo bay Urayasu-Ichikawa Medical Center, Tokyo
RECRUITING
Wakayama Medical University, Wakayama
RECRUITING
ZGT Almelo, Almelo
ACTIVE_NOT_RECRUITING
OLVG, Amsterdam
RECRUITING
Rijnstate Hospital, Arnhem
ACTIVE_NOT_RECRUITING
Deventer Hospital, Deventer
ACTIVE_NOT_RECRUITING
Ziekenhuis Gelderse Vallei, Ede
ACTIVE_NOT_RECRUITING
Maxima Medisch Centrum Eindhoven, Eindhoven
ACTIVE_NOT_RECRUITING
Medisch Centrum Leeuwarden, Leeuwarden
ACTIVE_NOT_RECRUITING
Laurentius Hospital, Roermond
RECRUITING
Maasstad Ziekenhuis, Rotterdam
RECRUITING
Hagaziekenhuis, The Hague
ACTIVE_NOT_RECRUITING
Bernhoven Hospital, Uden
RECRUITING
University Medical Center Utrecht, Utrecht
RECRUITING
North Shore Hospital, Auckland
RECRUITING
Whangarei Hospital, Whangarei
SUSPENDED
Hospital Ocidental, Lisbon
SUSPENDED
"Clinical Hospital of Infectious and Tropical Diseases Dr. Victor Babes", Bucharest
ACTIVE_NOT_RECRUITING
Basildon Hospital, Basildon
RECRUITING
Basingstoke and North Hampshire Hospital, Basingstoke
ACTIVE_NOT_RECRUITING
Royal United Hospital, Bath, Bath
RECRUITING
Queen Elizabeth Hospital Birmingham, Birmingham
RECRUITING
Birmingham City Hospital, Birmingham
RECRUITING
Royal Blackburn Teaching Hospital, Blackburn
SUSPENDED
Pilgrim Hospital ULHT, Boston
ACTIVE_NOT_RECRUITING
Royal Bournemouth Hospital, Bournemouth
SUSPENDED
Royal Sussex County Hospital, Brighton
SUSPENDED
Southmead Hospital, Bristol
ACTIVE_NOT_RECRUITING
Bristol Royal Infirmary, Bristol
ACTIVE_NOT_RECRUITING
Queen's Hospital, Burton, Burton-on-Trent
ACTIVE_NOT_RECRUITING
Royal Papworth Hospital, Cambridge
ACTIVE_NOT_RECRUITING
Addenbrookes Hospital, Cambridge
SUSPENDED
North Cumberland Infirmary, Carlisle
ACTIVE_NOT_RECRUITING
St Peter's Hospital, Chertsey
ACTIVE_NOT_RECRUITING
Countess of Chester Hospital, Chester
RECRUITING
Chesterfield Royal Hospital, Chesterfield
RECRUITING
Colchester Hospital, Colchester
ACTIVE_NOT_RECRUITING
University Hospital Coventry, Coventry
SUSPENDED
Darlington Memorial Hospital, Darlington
WITHDRAWN
Darent Valley Hospital, Dartford
ACTIVE_NOT_RECRUITING
Russells Hall Hospital, Dudley
SUSPENDED
Royal Devon and Exeter Hospital, Exeter
SUSPENDED
Frimley Park Hospital, Frimley
ACTIVE_NOT_RECRUITING
Queen Elizabeth Hospital Gateshead, Gateshead
COMPLETED
Medway Maritime Hospital, Gillingham
COMPLETED
James Paget University Hospital, Great Yarmouth
RECRUITING
Royal Surrey County Hospital, Guildford
ACTIVE_NOT_RECRUITING
Northwick Park Hospital, Harrow
RECRUITING
Hereford County Hospital, Hereford
ACTIVE_NOT_RECRUITING
Barnet Hospital, High Barnet
ACTIVE_NOT_RECRUITING
Huddersfield Royal Infirmary, Huddersfield
ACTIVE_NOT_RECRUITING
King George Hospital, Ilford
WITHDRAWN
Ipswich Hospital, Ipswich
RECRUITING
Kettering Hospital, Kettering
ACTIVE_NOT_RECRUITING
Leeds General Infirmary, Leeds
RECRUITING
St. James University Hospital, Leeds
SUSPENDED
Leicester Royal Infirmary, Leicester
SUSPENDED
Glenfield Hospital, Leicester
SUSPENDED
Lincoln County Hospital, Lincoln
COMPLETED
Liverpool Heart and Chest Hospital, Liverpool
COMPLETED
Alder Hey Hospital, Liverpool
ACTIVE_NOT_RECRUITING
Royal Liverpool University Hospital, Liverpool
SUSPENDED
University Hospital Aintree, Liverpool
ACTIVE_NOT_RECRUITING
Croydon University Hospital, London
ACTIVE_NOT_RECRUITING
Royal London Hospital, London
ACTIVE_NOT_RECRUITING
Whipps Cross Hospital, London
ACTIVE_NOT_RECRUITING
Newham University Hospital, London
ACTIVE_NOT_RECRUITING
St Bartholomew's Hospital, London
ACTIVE_NOT_RECRUITING
North Middlesex University Hospital, London
ACTIVE_NOT_RECRUITING
Royal Free Hospital, London
RECRUITING
St Thomas Hospital, London
ACTIVE_NOT_RECRUITING
Guy's Hospital, London
ACTIVE_NOT_RECRUITING
Queen Elizabeth Hospital, Woolwich, London
RECRUITING
King's College Hospital, London
RECRUITING
St George's University Hospital, London
ACTIVE_NOT_RECRUITING
Royal Marsden Hospital, London
ACTIVE_NOT_RECRUITING
Royal Brompton Hospital, London
RECRUITING
Hammersmith Hospital, London
RECRUITING
St Mary's Hospital, London
RECRUITING
Charing Cross Hospital, London
SUSPENDED
Luton and Dunstable University Hospital, Luton
RECRUITING
Maidstone Hospital, Maidstone
SUSPENDED
Manchester Royal Infirmary, Manchester
COMPLETED
The Christie Hospital, Manchester
SUSPENDED
Wythenshawe Hospital, Manchester
ACTIVE_NOT_RECRUITING
North Manchester General Hospital, Manchester
RECRUITING
Arrowe Park Hospital, Metropolitan Borough of Wirral
RECRUITING
The James Cook University Hospital, Middlesbrough
RECRUITING
Milton Keynes University Hospital, Milton Keynes
SUSPENDED
Royal Victoria Infirmary, Newcastle, Newcastle
RECRUITING
Newcastle Royal Victoria Infirmary (Paediatrics), Newcastle upon Tyne
SUSPENDED
Newcastle Freeman Hospital, Newcastle
SUSPENDED
Northampton General Hospital, Northampton
COMPLETED
Norfolk and Norwich University Hospital, Norwich
RECRUITING
City Hospital Nottingham, Nottingham
RECRUITING
Queen's Medical Centre - Nottingham University Hospitals NHS Trust, Nottingham
ACTIVE_NOT_RECRUITING
George Eliot Hospital, Nuneaton
RECRUITING
Royal Oldham Hospital, Oldham
SUSPENDED
Princess Royal University Hospital, Orpington
ACTIVE_NOT_RECRUITING
John Radcliffe Hospital, Oxford
RECRUITING
Derriford Hospital, Plymouth
RECRUITING
Poole Hospital NHS Foundation Trust, Poole
RECRUITING
Queen Alexandra Hospital, Portsmouth
TERMINATED
Whiston Hospital, Prescot
SUSPENDED
Royal Preston Hospital, Preston
RECRUITING
Royal Berkshire Hospital, Reading
ACTIVE_NOT_RECRUITING
Alexandra Hospital, Redditch, Redditch
ACTIVE_NOT_RECRUITING
Queen's Hospital Romford, Romford
RECRUITING
Rotherham Hospital, Rotherham
RECRUITING
Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust, Royal Tunbridge Wells
RECRUITING
Salford Royal Hospital, Salford
RECRUITING
Salisbury District Hospital, Salisbury
RECRUITING
Royal Hallamshire Hospital, Sheffield
RECRUITING
Northern General Hospital, Sheffield
ACTIVE_NOT_RECRUITING
Wexham Park Hospital, Slough
RECRUITING
South Tyneside District Hospital, South Shields
RECRUITING
Southampton General Hospital, Southampton
RECRUITING
Stepping Hill Hospital, Stockport
RECRUITING
University Hospital of North Tees, Stockton-on-Tees
RECRUITING
Royal Stoke University Hospital, Stoke-on-Trent
RECRUITING
Sunderland Royal Hospital, Sunderland
RECRUITING
King's Mill Hospital, Sutton in Ashfield
ACTIVE_NOT_RECRUITING
Great Western Hospital, Swindon
RECRUITING
Western General Hospital, Swindon
RECRUITING
Musgrove Park Hospital, Taunton
RECRUITING
Torbay Hospital, Torquay
RECRUITING
Royal Cornwall Hospital, Truro
COMPLETED
Harefield Hospital, Uxbridge
RECRUITING
Watford General Hospital, Watford
ACTIVE_NOT_RECRUITING
Southend Hospital, Westcliff-on-Sea
WITHDRAWN
West Cumberland Hospital, Whitehaven
ACTIVE_NOT_RECRUITING
Royal Albert Edward Infirmary, Wigan
RECRUITING
Royal Hampshire County Hospital, Winchester
ACTIVE_NOT_RECRUITING
New Cross Hospital Wolverhampton, Wolverhampton
ACTIVE_NOT_RECRUITING
Worcestershire Royal Hospital, Worcester
RECRUITING
York Teaching Hospital, York
RECRUITING
Antrim Area Hospital, Antrim
RECRUITING
Royal Victoria Hospital Belfast, Belfast
RECRUITING
Mater Hospital, Belfast
RECRUITING
Belfast City Hospital, Belfast
RECRUITING
Altnagelvin Hospital, Londonderry
COMPLETED
Aberdeen Royal Infirmary, Aberdeen
RECRUITING
Ninewells Hospital, Dundee
RECRUITING
Royal Infirmary of Edinburgh, Edinburgh
RECRUITING
Glasgow Royal Infirmary, Glasgow
RECRUITING
Queen Elizabeth University Hospital, Glasgow, Glasgow
RECRUITING
Royal Alexandra Hospital, Paisley
ACTIVE_NOT_RECRUITING
Neville Hall Hospital, Abergavenny
ACTIVE_NOT_RECRUITING
Glan Clwyd Hospital, Bodelwyddan
ACTIVE_NOT_RECRUITING
Princess of Wales Hospital, Bridgend
ACTIVE_NOT_RECRUITING
Cardiff and Vale University Hospital Wales, Cardiff
SUSPENDED
Glangwilli Hospital, Carmarthen
ACTIVE_NOT_RECRUITING
Grange University Hospital, Cwmbran
SUSPENDED
Royal Gwent Hospital, Newport
ACTIVE_NOT_RECRUITING
Royal Glamorgan Hospital, Pont-y-clun
ACTIVE_NOT_RECRUITING
Morriston Hospital, Swansea
RECRUITING
Wrexham Maelor Hospital, Wrexham
RECRUITING
Ulster Hospital, Belfast
RECRUITING
Bristol Royal Childrens Hospital, Bristol
RECRUITING
Fairfield General Hospital, Bury
RECRUITING
Leighton Hospital, Crewe
COMPLETED
Dorset County Hospital, Dorchester
COMPLETED
Gloucester Royal Hospital, Gloucester
ACTIVE_NOT_RECRUITING
The Princess Royal Hospital Haywards Heath, Haywards Heath
SUSPENDED
Homerton Hospital, London
RECRUITING
University College London Hospital, London
RECRUITING
Chelsea and Westminster Hospital, London
SUSPENDED
Queen Elizabeth and Queen Mother Hospital, Margate
SUSPENDED
North Tyneside General Hospital, North Shields
ACTIVE_NOT_RECRUITING
Warwick Hospital, Warwick
RECRUITING
Sandwell General Hospital, West Bromwich
Collaborators (2)
Australian and New Zealand Intensive Care Research Centre
OTHER
Medical Research Institute of New Zealand
OTHER
Unity Health
OTHER
Berry Consultants
OTHER
Global Coalition for Adaptive Research
OTHER
University of Pittsburgh Medical Center
OTHER
Intensive Care National Audit & Research Centre
OTHER
St. Marianna University School of Medicine
OTHER
Nat Intensive Care Surveillance - MORU
OTHER
National University Hospital, Singapore
OTHER
UMC Utrecht
OTHER