36
Participants
Start Date
November 9, 2016
Primary Completion Date
September 3, 2018
Study Completion Date
October 7, 2019
Atezolizumab [TECENTRIQ]
"Atezolizumab will be administered by intravenous (IV) infusion at a flat dose of 1200 milligram (mg) every 3 weeks (Q3W) on Day 1 of Cycles 2-6, given in 21-day cycles during induction treatment.~NOTE: Atezolizumab treatment has been discontinued in all participants currently on study treatment."
Obinutuzumab
Obinutuzumab will be administered by IV infusion at a flat dose of 1000 mg on Days 1, 8, and 15 of Cycle 1, and on Day 1 of Cycles 2-6, given in 21-day cycles during induction treatment, and on Day 1 of every other month during maintenance treatment (1 cycle=21 days; infusion rate starts at 50 mg/hour (hr) and increases every 30 min to a maximum of 400 mg/hr).
Polatuzumab Vedotin
Polatuzumab vedotin will be administered by IV infusion. For relapsed or refractory FL either 1.4 mg/kilogram (kg) or 1.8 mg/kg (dose-escalation phase) and at RP2D (dose-expansion phase) on Day 1 of Cycles 1-6 will be given in 21-day cycles during induction treatment. For relapsed or refactory DLBCL, 1.8 mg/kg will be given during run-in phase and either 1.8 mg/kg or 1.4 mg/kg during the expansion phase (1 cycle=21 days; infusion rate starts with 90 min and decreases to 30 min).
Rituximab
Rituximab will be administered by IV infusion at 375 mg/m˄2 on Day 1 of Cycles 1-6 during induction treatment (1 cycle-21 days; infusion rate starts with 50 mg/hr and increases every 30 min to a maximum of 400 mg/hr).
Wojewódzki Szpital Specjalistyczny im.MikołajaKopernika;KlinikaHematologiiUniwersytetuMedycznego, Lodz
Stony Brook University Hospital, Stony Brook
Universitätsklinikum Greifswald Klinik für Innere Medizin C und Poliklinik, Greifswald
Robert Byrd Health Science; Dept of Medicine, Section of Hematology/Oncology, Morgantown
Medizinische Hochschule; Zentrum Innere Medizin; Abt. Hämatologie u. Onkologie, Hanover
University Miami, Miami
Uniklinik Essen, Essen
Universitatsklinikum Frankfurt, Frankfurt
Klinikum rechts der Isar der Technischen Universität München, München
UCLA, Los Angeles
Universitätsklinikum Würzburg, Würzburg
Columbia Basin Hem-Onc; Department Hematology Oncology, Kennewick
Städtisches Klinikum Dessau Klinik für Innere Medizin Abt. Intensivmedizin, Dessau
Universitätsklinikum Jena Klinik f.Chirurgie Abt. Allgemein- und Viszeralchirurgie, Jena
Szpitale Wojewodzkie w Gdyni Sp. z o.o., Gdynia
MTZ Clinical Research Sp. z o.o., Warsaw
Instytut Hematologii i Transfuzjologii; Klinika Zaburzeń Hemostazy i Chorób Wewnętrznych, Warsaw
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Klinika Nowotworow Ukladu Chlonnego, Warsaw
Medical Uni of Wroclaw; Hematology, Wroclaw
Hoffmann-La Roche
INDUSTRY