Breast Cancer Lung Late Effects

CompletedOBSERVATIONAL
Enrollment

41

Participants

Timeline

Start Date

May 31, 2016

Primary Completion Date

January 14, 2022

Study Completion Date

January 14, 2022

Conditions
Radiation InjuryBreast Cancer
Interventions
RADIATION

Proton beam radiation therapy.

Proton bean radiation therapy interact differently with tissue with the result that protons are absorbed completely within the tissue instead of primarily passing through the entire body. The maximal depth of penetration is dependent upon the incoming velocity (energy) of the protons. Proton therapy utilizes this property to deliver radiation with very little dose beyond the targeted lesion. The dose-rate will be managed as part of the standard of care.

RADIATION

X-ray based radiation therapy

The three-dimensional (3D) mapping of radiation dose distributions permits detailed assessment of local vascular damage as a function of treatment factors of dose, dose-rate. The dose-rate will be managed as part of the standard of care.

PROCEDURE

Computed Tomography (CT) Scan

Computed Tomography (CT) Scan of the chest will be performed at 1, 3, 6, 12, 18 and 24 months

PROCEDURE

Pulmonary Function Test (PFT)

Pulmonary function test (PFT) will be performed at pre-treatment, and at 6 and 12 months.

Trial Locations (2)

32206

University of Florida Health Proton Therapy Institute, Jacksonville

32611

Department of Radiation Oncology Davis Cancer Pavilion, Gainesville

All Listed Sponsors
collaborator

Florida Department of Health

OTHER_GOV

lead

University of Florida

OTHER

NCT02725840 - Breast Cancer Lung Late Effects | Biotech Hunter | Biotech Hunter