Effect of Apelin on Insulin Sensitivity in Type 2 Diabetic Volunteers

Assessing the difference between the insulin sensitivity measured during hyperinsulinemic euglycemic clamps in the presence of a 2 hours continuous infusion of (PYR1)-apelin-13 (30nmol/kg) versus a 2 hours continuous infusion of placebo (vehicle alone).

2 hours continuous infusion of placebo (vehicle alone) to compare with 2 hours infusion of apelin