700
Participants
Start Date
April 30, 2016
Primary Completion Date
December 31, 2031
Study Completion Date
December 31, 2032
Gemtuzumab ozogamicin
Antibody-conjugated chemotherapy agent.
Liposomal daunorubicin
"Anthracycline~(Randomisation 1 (R1)) closed early to recruitment on 8th September 2017, due to liposomal daunorubicin manufacturing issues resulting in unavailability of the drug."
Mitoxantrone
DNA-reactive agent
Fludarabine
A water-soluble fluorinated nucleotide analogue of the antiviral agent vidarabine.
Cytarabine
Pyrimidine nucleoside analogue, an antineoplastic agent.
Busulfan
Alkylsulfonate
Cyclophosphamide
A nitrogen mustard alkylating agent from the oxazaphosphorine group
RECRUITING
Women and Children's Hospital Adelaide, Adelaide
RECRUITING
Queensland Children's Hospital, Brisbane
RECRUITING
Monash Children's Hospital, Melbourne
RECRUITING
Royal Childrens Hospital, Melbourne
RECRUITING
John Hunter Children's Hopsital, New Lambton Heights
RECRUITING
Perth Children's Hospital, Perth
RECRUITING
Sydney Children's Hospital, Sydney
RECRUITING
The Childrens Hospital At Westmead, Westmead
RECRUITING
Centre Hospitalier Universitaire Amiens - Picardie, Amiens
RECRUITING
Centre Hospitalier Universitaire D'angers, Angers
RECRUITING
Centre Hospitalier Regional Universitaire Besancon - Hopital Jean Minjoz, Besançon
RECRUITING
Centre Hospitalier Universitaire De Bordeaux - Hopital Pellegrin, Bordeaux
RECRUITING
Centre Hospitalier Regional Universitaire Brest - Hopital Morvan, Brest
RECRUITING
Centre Hospitalier Universitaire De Caen, Caen
RECRUITING
Centre Hospitalier Universitaire De Clermont-ferrand, Clermont-Ferrand
RECRUITING
Centre Hospitalier Universitaire Dijon Bourgogne - Hopital D'enfants, Dijon
RECRUITING
Centre Hospitalier Universitaire De Grenoble, Grenoble
RECRUITING
Hopital Jeanne Dr Flandre, Lille
RECRUITING
Centre Hospitalier Universitaire De Limoges, Limoges
RECRUITING
Centre Leon Berard, Lyon
RECRUITING
Hopital De La Timone, Marseille
RECRUITING
Centre Hospitalier Regional Universitaire Montpellier - Hopital Arnaud-de-villeneuve, Montpellier
RECRUITING
Centre Hospitalier Universitaire De Nancy, Nancy
RECRUITING
Centre Hospitalier Universitaire De Nantes, Nantes
RECRUITING
Centre Hospitalier Universitaire De NICE, Nice
RECRUITING
Hopital Armand Trousseau, Paris
RECRUITING
Hopital Robert Debre, Paris
RECRUITING
Hopital Saint Louis, Paris
RECRUITING
Centre Hospitalier Universitaire De Poitiers, Poitiers
RECRUITING
Chu De Reims, Reims
RECRUITING
Centre Hospitalier Universitaire De Rennes - Hopital Sud, Rennes
RECRUITING
Centre Hospitalier Universitaire De Rouen, Rouen
RECRUITING
Centre Hospitalier Universitaire Saint-etienne, Saint-Etienne
RECRUITING
Strasbourg Hautepierre, Strasbourg
RECRUITING
Centre Hospitalier Universitaire De Toulouse - Hopital Des Enfants, Toulouse
RECRUITING
Centre Hospitalier Regional Universitaire De Tours - Hopital Clocheville, Tours
RECRUITING
Our Lady's Hospital for Sick Children, Dublin
RECRUITING
Starship Childrens Hospital, Auckland
RECRUITING
Christchurch Hospital, Christchurch
RECRUITING
Kantonsspital Aarau, Aarau
RECRUITING
Universitäts-Kinderspital beider, Basel
RECRUITING
Ospedale San Giovanni, Bellinzona
RECRUITING
Inselspital Bern, Bern
RECRUITING
Hug Hopitaux Universitaires De Geneve, Geneva
RECRUITING
Centre Hospitalier Universitaire Vaudois Chuv Lausanne, Lausanne
RECRUITING
Luzerner Kantonspital - Kinderspital Luzern, Lucerne
RECRUITING
Ostschweizer Kinderspital, Sankt Gallen
RECRUITING
University Children's Hospital Zurich, Zurich
RECRUITING
Royal Belfast Hospital for Sick Children, Belfast
RECRUITING
Royal Aberdeen Children's Hospital, Aberdeen
RECRUITING
Aberdeen Royal Infirmary, NHS Grampian, Aberdeen
RECRUITING
Birmingham Children's Hospital NHS Foundation Trust, Birmingham
RECRUITING
University Hospitals Bristol NHS Foundation Trust, Bristol
RECRUITING
Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge
RECRUITING
Cardiff and Vale University Health Board, Noah's Ark Children's Hospital for Wales, Cardiff
RECRUITING
NHS Lothian, Royal Hospital for Sick Children, Edinburgh
RECRUITING
NHS Greater Glasgow and Clyde, The Royal Hospital for Children, Glasgow
RECRUITING
Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds
RECRUITING
Alder Hey Children's NHS Foundation Trust, Liverpool
RECRUITING
University College London Hospitals NHS Foundation Trust, London
RECRUITING
The Royal Marsden NHS Foundation Trust, London
RECRUITING
Great Ormond Street Hospital For Children NHS Trust, London
RECRUITING
Royal Manchester Childrens' Hospital , Central Manchester University Hospitals NHS Foundation Trust, Manchester
RECRUITING
The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle
RECRUITING
Nottingham University Hospitals NHS Trust, Nottingham
RECRUITING
John Radcliffe Hospital, Oxford Radcliffe Hospitals NHS Trust, Oxford
RECRUITING
Sheffield Children's NHS Foundation Trust, Sheffield
RECRUITING
Southampton University Hospitals NHS Trust, Southampton
Collaborators (2)
Assistance Publique - Hôpitaux de Paris
OTHER
Cancer Research UK
OTHER
National Cancer Institute, France
OTHER_GOV
Pfizer
INDUSTRY
University of Birmingham
OTHER