171
Participants
Start Date
September 30, 2016
Primary Completion Date
February 1, 2026
Study Completion Date
February 1, 2026
Ruxolitinib
In Part 1, ruxolitinib will be administered at a protocol-defined starting dose in combination with chemotherapy, with dose escalation and de-escalation following the rolling 6 study design. The established recommended starting dose will be taken forward into Part 2.
Asparaginase Erwinia Chrysanthemi
Cyclophosphamide
Cytarabine
Dexamethasone
Doxorubicin
Leucovorin Calcium
Mercaptopurine
Methotrexate
Pegaspargase
Prednisone
Thioguanine
Vincristine Sulfate
Weill Cornell Medical College, New York
Nyu Clinical Cancer Center, New York
New York Medical College, Valhalla
Cohen Children'S Medical Center, New Hyde Park
Albany Medical College, Albany
Suny Upstate Medical University, Syracuse
Roswell Park Comprehensive Cancer Center, Buffalo
University of Rochester Medical Center, Rochester
Childrens Hospital of Pittsburgh, Pittsburgh
Children'S Hospital of Philadelphia, Philadelphia
Alfred I. Dupont Hospital For Children, Wilmington
Sinai Hospital of Baltimore, Baltimore
Children'S Hospital of the, Norfolk
Wake Forest University, Winston-Salem
University of North Carolina At Chapel Hill, Chapel Hill
Carolinas Medical Center, Charlotte
Medical University of South Carolina, Charleston
Nemours Childrens Clinic, Jacksonville
University of Florida Health Shands Hospital, Jacksonville
Nemours Childrens Clinic, Pensacola
Florida Hospital Orlando, Orlando
Arnold Palmer Hospital For Children, Orlando
Joe Dimaggio Children Hospital, Hollywood
Saint Marys Medical Center, West Palm Beach
St Josephs Childrens Hospital Tampa, Tampa
All Childrens Hospital, St. Petersburg
Childrens Hospital of Southwest Florida, Fort Myers
The Childrens Hospital of Alabama, Birmingham
Vanderbilt University Medical Center, Nashville
University of Mississippi Medical Center, Jackson
Kosair Childrens Hospital, Louisville
University of Kentucky, Lexington
Nationwide Children'S Hospital, Columbus
Toledo Hospital, Toledo
Rainbow Babies & Children Hosp, Cleveland
Cleveland Clinic Foundation, Cleveland
Akron Children'S Hospital, Akron
Cincinnati Childrens Hospital Medical Center, Cincinnati
Dayton Children'S Hospital, Dayton
Riley Hospital For Children, Indianapolis
St Vincent Hospital, Indianapolis
Cs Mott Childrens Hospital, Ann Arbor
Michigan State University, Lansing
Helen Devos Childrens Hosp, Grand Rapids
Blank Childrens Hospital, Des Moines
University of Iowa Hospital and Clinics, Iowa City
Medical College of Wisconsin, Milwaukee
St Vincent Hospital, Green Bay
Children'S Hospitals and Clinics of Minnesota, Minneapolis
University of Minnesota, Minneapolis
Ann & Robert H. Lurie Children'S Hospital, Chicago
Southern Illinois University School of Medicine, Springfield
Washington University, St Louis
The Children'S Mercy Hospital Outpatient, Kansas City
Children'S Hospital & Medical Center, Omaha
Ochsner Clinic, New Orleans
Arkansas Childrens Hospital, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
University of Texas Southwestern Medical Center, Dallas
Texas Childrens Hospital, Houston
University of Texas Health Science Cente, San Antonio
Driscoll Children'S Hospital, Corpus Christi
Dell Childrens Medical Center of Central Texas, Austin
El Paso Children'S Hospital Corporation, El Paso
Children'S Hospital Colorado, Aurora
Primary Children'S Hospital, Salt Lake City
University of New Mexico Hospital, Albuquerque
Alliance For Childhood Diseases, Las Vegas
Children'S Center For Cancer & Blood Dis, Las Vegas
Children'S Hospital Los Angeles, Los Angeles
Kaiser Foundation Health Plan, Los Angeles
Southern California Permanente Medical Group, Los Angeles
Kaiser Permanente Downey, Santa Fe Springs
Miller Childrens Hospital Pharmacy, Long Beach
Kaiser Permanente, San Diego
Rady Children'S Hospital - San Diego, San Diego
Kaiser Permanente, Fontana
Loma Linda University Cancer Center, Loma Linda
Choc Children Hospital, Orange
Ucsf Pediatric Oncology, San Francisco
Lucille Packard Childrens Hospital, Palo Alto
The Hospital For Sick Children, Toronto
Kapiolani Medical Center For Women and Children, Honolulu
Legacy Emanuel Hospital and Health Center, Portland
Doernbecher Childrens Hospital, Portland
Seattle Children'S Hospital, Seattle
Providence Sacred Heart Medical Center & Children'S Hospital, Spokane
Phoenix Children'S Hospital, Phoenix
Valley Childrens Hospital, Madera
Connecticut Children'S Medical Ctr, Hartford
Smilow Cancer Center - Yale, New Haven
Egleston Children'S Health, Atlanta
Loyola University Medical Center, Maywood
Maine Center For Cancer Medicine, Scarborough
Johns Hopkins University, Baltimore
Dana Farber Boston Children'S, Boston
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Rutgers Cancer Institute of Nj, New Brunswick
Newark Beth Israel Medical Center, Newark
St Josephs Regional Medical Center, Paterson
Penn State Hershey Medical Center, Hershey
Hasbro Childrens Hospital, Providence
Alberta'S Children Hospital, Calgary
Bc Children'S Hospital, Vancouver
Chu Sainte-Justine, Montreal
McGill University Health Centre/Glen Site/Cedars Cancer Centre, Montreal
McMaster University Medical Centre, Hamilton
University Pediatric Hospital, San Juan
San Jorge Childrens Hospital, San Juan
Lead Sponsor
Children's Oncology Group
NETWORK
Incyte Corporation
INDUSTRY