66
Participants
Start Date
November 30, 2007
Primary Completion Date
January 31, 2025
Study Completion Date
January 31, 2025
MRI at baseline and over time
Hyperpolarized noble gas MRI has been used to explore structural and functional relationships in the lung in patients with lung disease and healthy controls. In contrast to proton-based MRI, Helium-3 and Xenon-129 gas is used as a contrast agent to directly visualize ventilation. Whereas the normal density of gas is too low to produce an easily detectable signal, this is overcome by artificially increasing the amount of polarization per unit volume using optical pumping.
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre, London
Western University, Canada
OTHER