314
Participants
Start Date
June 27, 2016
Primary Completion Date
August 14, 2019
Study Completion Date
August 14, 2019
BACLOFEN
Daily doses will be adapted to daily MDRD creatinine clearance from 150 to 50mg. On the day of randomisation, the patient will receive the full daily dose in a one-shot administration. Then daily doses will be divided into 3 intakes on the following days. During the mechanical ventilation period, the treatment will be administered via the nasogastric feeding tube. After extubation, the treatment will be administered either via the nasogastric tube or the oral route.
PLACEBO
Daily doses will be adapted to daily MDRD creatinine clearance from 150 to 50mg. On the day of randomisation, the patient will receive the full daily dose in a one-shot administration. Then daily doses will be divided into 3 intakes on the following days. During the mechanical ventilation period, the placebo will be administered via the nasogastric feeding tube. After extubation, the placebo will be administered either via the nasogastric tube or the oral route.
CHU ANGERS - réanimation chirurgicale, Angers
CHU de Brest Réanimation Chirurgicale, Brest
CHU de Brest Réanimation Médicale, Brest
CHU de Caen Réanimation Médicale, Caen
CHD La Roche Sur YON, La Roche-sur-Yon
CH Le Mans, Le Mans
Centre Hospitalier de Bretagne Sud Réanimation Polyvalente Lorient, Lorient
CHU MONTPELLIER - Lapeyronie, Montpellier
Chu Montpellier, Montpellier
CHU NANTES - réanimation chirurgicale, Nantes
CHU NANTES -réanimation médicale, Nantes
Hopital Saint Antoine, Paris
Chu Poitiers, Poitiers
Ch Cornouaille, Quimper
Chu Rennes, Rennes
CHR Saint Nazaire, Saint-Nazaire
CHRU Tours Bretonneau, Tours
Chu Tours, Tours
Nantes University Hospital
OTHER