Defining the Physiological Mechanisms of Risk Genes for Hyperglycaemia, Insulin Resistance and Type 2 Diabetes

UnknownOBSERVATIONAL
Enrollment

40

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

July 31, 2016

Study Completion Date

July 31, 2016

Conditions
Type 2 Diabetes
Interventions
OTHER

4 Hour Frequently Sampled Oral Glucose Tolerance Test

Blood glucose level(BGL) every 5 min, blood for hormone, biochemical analysis at -15,0,15,30,45,60,90,120,180, 240

OTHER

Isoglycaemic Clamp

Glucose infusion over 4 hours to reproduce OGTT glucose curve to allow measurement of incretin effect. BGL every 5 min, blood for hormone, biochemical analysis at -15,0,15,30,45,60,90,120,180, 240

Trial Locations (1)

OX3 7LE

RECRUITING

OCDEM, University of Oxford, Oxford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Exeter

OTHER

collaborator

Medical Research Council

OTHER_GOV

lead

University of Oxford

OTHER