Breathlessness Exertion and Morphine Sulphate

PHASE3CompletedINTERVENTIONAL
Enrollment

171

Participants

Timeline

Start Date

August 8, 2016

Primary Completion Date

December 20, 2019

Study Completion Date

December 20, 2019

Conditions
Chronic Obstructive Pulmonary DiseaseDyspnea
Interventions
DRUG

Placebo

Treatment with placebo is given as one double-blind capsule in the morning.

DRUG

Morphine Sulfate

Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

DRUG

Plus laxative (Docusate with senna)

If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

DRUG

Plus placebo laxative

If the patients are taking placebo, a placebo laxative will be offered.

DEVICE

FitBit charge HR (Accelerometer)

A Fitbit will be worn by patients during week 1 and week 3.

Trial Locations (15)

2010

St Vincent's Hospital Sydney - Sacred Heart Hospice, Darlinghurst

2139

Concord Hospital, Concord

2145

Westmead Hospital, Westmead

2170

Liverpool Hospital, Liverpool

2600

Clare Holland House, Canberra

3050

Royal Melbourne Hospital, Melbourne

3065

St Vincent's Hospital Melbourne, Fitzroy

3084

The Austin Hospital, Heidelberg

3215

Barwon Health McKellar Centre, Geelong

3590

Calvary Health Care Kogarah, Kogarah

4032

Prince Charles Hospital, Brisbane

4560

Nambour Hospital, Sunshine Coast

5041

Southern Adelaide Palliative Services, Adelaide

6009

Sir Charles Gairdner Hospital, Perth

8140

Canterbury Respiratory Services, Christchurch

All Listed Sponsors
lead

Flinders University

OTHER

NCT02720822 - Breathlessness Exertion and Morphine Sulphate | Biotech Hunter | Biotech Hunter