492
Participants
Start Date
March 14, 2016
Primary Completion Date
November 4, 2019
Study Completion Date
November 4, 2019
Biological: PEGylated Recombinant Human Hyaluronidase (PEGPH20)
PEGPH20 will be administered as per the dose and schedule specified in the respective arms.
Placebo
Matching placebo for PEGPH20
nab-Paclitaxel
Nab-paclitaxel will be administered as per the dose and schedule specified in the respective arms.
Gemcitabine
Gemcitabine will be administered as per the dose and schedule specified in the respective arms.
Cliniques Universitaires Saint-Luc, Brussels
NYU Langone Medical Center - NYU Langone Arena Oncology, New Hyde Park
Columbia University Medical Center, New York
Mount Sinai School of Medicine - The Tisch Cancer Institute, New York
Northwell Health/Monter Cancer Center, Lake Success
University of Rochester Medical Center, Rochester
Allegheny General Hospital, Pittsburgh
Univ of Pittsburgh Cancer institute, Pittsburgh
Penn State Milton S. Hershey Medical Center, Hershey
MedStar Georgetown University Hospital, Washington D.C.
The Sidney Kimmel Comprehensive Cancer Center, Baltimore
Inova Dwight and Martha Schar Cancer Institute, Fairfax
Fort Belvoir Community Hospital, Fort Belvoir
Virginia Cancer Institute, Mechanicsville
Rex Cancer Center, Raleigh
21st Century Oncology, Jacksonville
MD Anderson Cancer Center Orlando, Orlando
Memorial Healthcare System - Memorial Cancer Institute, Hollywood
University of South Alabama, Mobile
University of Louisville, Louisville
Gabrail Cancer Center Research, Canton
Fort Wayne Medical Oncology/Hematology, INC., Fort Wayne
University of Michigan Medical Center, Ann Arbor
Karmanos Cancer Institute, Detroit
Columbia St. Marys, Milwaukee
Medical College of Wisconsin, Milwaukee
University of Wisconsin Health - UW Carbone Cancer Center, Madison
Virginia Piper Cancer Institute, Minneapolis
University of Minnesota Medical School, Minneapolis
The University Of Kansas Cancer Center, Kansas City
Ochsner Clinic CCOP, New Orleans
Ochsner Health Center, Baton Rouge
Highlands Oncology Group, Fayetteville
The University of Oklahoma Health Sciences Center, Oklahoma City
Scott and White, Temple
Baylor College of Medicine - Baylor Clinic, Houston
Kaiser Permanente Franklin Medical Offices - Denver, Denver
US Oncology - Rocky Mountain Cancer Centers - Midtown, Denver
St. Mary's Medical Center, Grand Junction
University of Utah - Huntsman Cancer Institute, Salt Lake City
Comprehensive Cancer Centers of Nevada, Las Vegas
Renown Regional Medical Center, Reno
Samuel Oschin Comprehensive Cancer Institute, Los Angeles
David Geffen School of Medicine (DGSOM) at UCLA, Los Angeles
Cancer Care Associates Medical Group, Inc., Redondo Beach
Innovative Clinical Research Institution, Whittier
Scripps Clinical Research Services, La Jolla
Desert Hematology Oncology Medical Group, Inc., Rancho Mirage
Chao Family Comprehensive Cancer Center, Orange
St. Joseph Hospital, Orange
St. Jude Hospital Yorba DBA Linda St. Joseph Heritage Health, Fullerton
Pacific Central Coast Health Centers: San Luis Obispo Oncology and Hematology Health Center, San Luis Obispo
Pacific Hematology Oncology Associates, San Francisco
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
St Joseph Heritage Healthcare, Santa Rosa
Swedish Cancer Institute/ Swedish Health Services, Seattle
University of Washington (UW) - Seattle Cancer Care Alliance, Seattle
Northwest Medical Specialties PLLC, Tacoma
Banner MD Anderson Cancer Center, Gilbert
Yale Cancer Center, New Haven
Beth Israel Deaconess Medical Center, Boston
UMass Memorial Medical Center, Worcester
Dartmouth Hitchcock Medical Center, Lebanon
Saint Joseph's Ambulatory Clinic, Clifton
Jersey Shore University Medical Center, Neptune City
Bankstown-Lidcombe Hospital, Bankstown
Chris O'Brien Lifehouse, Camperdown
St Vincent's Hospital, Darlinghurst
Royal North Shore Hospital, St Leonards
Flinders Medical Centre, Bedford
Bendigo Health Care Group, Bendigo
Monash Health, Bentleigh East
Peninsula & South Eastern Haematology and Oncology Group, Frankston
Imelda Ziekenhuis, Bonheiden
UZA, Edegem
Hôpital Erasme, Brussels
AZ Maria Middelares - Campus Maria Middelares, Ghent
UZ Leuven - Campus Gasthuisberg, Leuven
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Un, Liège
CENANTRON - Centro Avançado de Tratamento Oncologico, Belo Horizonte
Hospital da Cidade de Passo Fundo, Passo Fundo
Hospital de Clinicas de Porto Alegre - UFRGS, Porto Alegre
Hospital São Lucas da PUCRS, Porto Alegre
Occ -Oncologia Clínica De Campinas, Campinas
Fundação Amaral Cravalho / Hospital Amaral Carvalho, Jaú
Fm Abc/ Cepho, Santo André
Faculdade de Medicina da Universidade de Sao Paulo, São Paulo
Fundacao Pio XII Hospital De Câncer de Barretos, Barretos
Instituto COI, Rio de Janeiro
Instituto Nacional de Câncer - INCA, Rio de Janeiro
Royal Victoria Regional Health Centre, Barrie
Princess Margaret Hospital, Toronto
Klinicki bolnicki centar Zagreb, Zagreb
Klinicki bolnički centar Sestre milosrdnice, Zagreb
Masarykuv onkologicky ustav, Brno
FN Hradec Kralove, Hradec Králové
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice v Motole, Prague
Nemocnice Na Bulovce (Hospital Na Bulovce), Prague
Odense Universitetshospital, Odense
East Tallinn Central Hospital Oncology Center, Tallinn
North Estonian Medical Centre Foundation Clinic of Oncology, Tallinn
Centre Eugene Marquis, Rennes
Hospitalier Jean Minjoz, Besançon
ICM Val d'Aurelle Saint Eloi - Departement Oncologie, Montpellier
ICO - Site Ren Gauducheau, Saint-Herblain
CHU Estaing, Clermont-Ferrand
Hopital Edouard Herriot, Lyon
Institut De Cancerologie Gustave Roussy, Villejuif
Institut de Cancérologie de l'Ouest - Site Paul Papin, Angers
Hôpital Haut-Leveque, Bordeaux
Henri Mondor - Albert Chevenier, Créteil
Centre Lyon Berard, Lyon
Hopital Privé Jean Mermoz, Lyon
Institut Mutualiste Montsouris, Paris
Pitié Salpetriere Hospital, Paris
Hôpital Beaujon, Clichy
Universitätsklinikum Ulm, Ulm
Klinikum der Universität München - Campus Grosshadern, München
Universitätsklinikum Bonn, Bonn
Uniklinik Köln-Klinik für Gastroenterologie und Hepatologie am Abdominalzentrum, Cologne
Universitätsklinik Carl-Gustav-Carus Dresden, Dresden
Universitätsklinikum Leipzig AöR, Leipzig
Charité - Universitätsmedizin Berlin, Berlin
Kliniken Essen-Mitte Evang. Huyssens-Stiftung, Essen
Universitätsklinikum Halle-Universitätsklinik und Poliklinik, Halle
Facharztzentrum Eppendorf, Hamburg
Universitätskllinikum Heidelberg, Heidelberg
Pécsi Tudományegyetem Klinikai Központ, Pécs
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpo, Szeged
Petz Aladár Megyei Oktató Kórház, Győr
Debreceni Egyetem Klinikai Központ, Debrecen
Egyesített Szent István és Szent László Kórház-Rendelőintéze, Budapest
Magyar Honvédség Egészségügyi Központ, Budapest
Országos Onkológiai Intézet, Budapest
Semmelweis Egyetem - Isz. Bel, Onkológiai Részleg, Budapest
Semmelweis Egyetem - Onkohaematológiai Osztály, Budapest
Szent Margit Kórház, Budapest
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár
Assaf Harofeh Medical Center, Be’er Ya‘aqov
Meir Medical Center, Kfar Saba
Rabin Medical Center - Beilinson Hospital, Petah Tikva
Hadassah Medical Organisation, Jerusalem
Tel Aviv Sourasky Medical Center, Tel Aviv
Ha'Emek Medical Center, Afula
Soroka Medical Center [Oncology], Beersheba
Hillel Yaffe Medical Center, Hadera
Rambam Health Care Campus, Haifa
Shaare Zedek Medical Center, Jerusalem
The Chaim Sheba Medical Center [Oncology], Tel Litwinsky
U.O. di Oncologia, San Giovanni Rotondo
Istituto Clinico Humanitas Rozzano, IRCCS, Rozzano
PO di Cremona, ASST di Cremona, Cremona
AO S. Martino, IRCCS, IST-Istituto Nazionale Ricerca Sul Cancro, Genova
Ieo, Irccs, Milan
IRCCS Ospedale S.Raffaele, Milan
Istituto Oncologico Veneto IOV-IRCCS, Padua
Regina Elena, Istituto Nazionale dei Tumori, IFO, IRCCS, Roma
Borgo Roma, Policlinico G.Rossi, AOU Integrata Verona, Verona
Daugavpils Regional Hospital, Daugavpils
P.Stradins Clinical University, Riga
"SIA Rigas Austrumu Kliniska Universitates Slimnica", Riga
National Cancer Institute, Vilnius
Vilniaus Universiteto ligonines Santariskiu Klinikos, Vilnius
Maastricht University Medical Centre, Maastricht
Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam
Spaarne Gasthuis, Hoofddorp
Radboud Universiteit Nijmegen, Nijmegen
Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onko, Brzozów
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie, Lublin
Centrum Onkologii Instytut im. M. Sklodowskiej-Curie, Warsaw
Dong-A University Hospital, Busan
Keimyung University Dongsan Medical Center, Daegu
Seoul National University Bundang Hospital, Seongnam
Asan Medical Center, Seoul
Korea University Anam Hospital, Seoul
Samsung Medical Center, Seoul
Severance Hospital, Yonsei University Health System, Seoul
The Catholic University of Korea, Seoul St.Mary's Hospital, Seoul
Gachon University Gil Medical Center, Incheon
Korea University Guro Hospital, Seoul
Seoul National University Hospital, Seoul
Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Badalona
Institut Catalá d´Oncología (I.C.O.), L'Hospitalet de Llobregat
H.U. de Fuenlabrada, Fuenlabrada
Clínica Universidad de Navarra, Pamplona
H.del Mar, Barcelona
H.Sta.Creu i St.Pau, Barcelona
H.U.Vall d'Hebrón, Barcelona
H.C. S.Carlos, Madrid
H.G.U. G. Marañón, Madrid
H.U. F. Jiménez Díaz, Madrid
H.U. R. y Cajal, Madrid
Hospital Madrid Norte Sanchinarro, Madrid
F.I. Valenciano de Oncología, Valencia
Hospital Universitari i Politècnic La Fe, Valencia
H.U. Miguel Servet, Zaragoza
China Medical University Hospital, Taichung
Changhua Christian Hospital, Changhua
National Cheng Kung University Hospital, Tainan City
National Taiwan University Hospital, Taipei
Veterans General Hospital- Taipei, Taipei
Addenbrooke's Hospital, Cambridge, Cambridge
Peterborough And Stamford Hospitals, Peterborough
Beatson West of Scotland Cancer Centre, Glasgow
Sarah Cannon Research Institute UK (SCRI UK), London
Edinburgh Cancer Centre Western General Hospital, Edinburgh
The Clatterbridge Cancer Centre NHS Foundation Trust, Birkenhead
Queen Elizabeth Hospital Birmingham, Birmingham
Castle Hill Hospital, Cottingham
Coventry Hospital, Coventry
Hammersmith Hospital, London
The Royal Marsden NHS Foundation - Sutton, London
The Royal Marsden NHS Foundation Trust - Chelsea, London
The Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral
North Wales Cancer Treatment Centre, Rhyl
The Christie NHS Foundation Trust, Withington
Lead Sponsor
Halozyme Therapeutics
INDUSTRY