NCT02715284View on ClinicalTrials.gov

Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

740

Participants

Timeline

Start Date

March 7, 2016

Primary Completion Date

May 18, 2026

Study Completion Date

October 27, 2027

Conditions
Neoplasms
Interventions
BIOLOGICAL

Dostarlimab

Dostarlimab (160 mg, 20 mg/mL; or 500 mg, 50 mg/mL) is a humanized monoclonal antibody that binds with high affinity to PD-1 resulting in inhibition of binding to programmed death receptor ligands 1 and 2 (PD-L1 and PD-L2). Dostarlimab will be administered via a 30 minute IV infusion on Day 1 and Day 15 of each cycle in Part 1. For additional patients enrolled specifically to better characterize the PK/PDy profile in Part 1, dostarlimab administration during Cycle 1 will only occur on Day 1 with the second dose administered on Cycle 2/Day 1 and Q2W thereafter. For Part 2A and 2B, dostarlimab will be administered on Day 1 of each treatment cycle. Cycle duration for Q3W dosing is 21 days and Q6W dosing is 42 days.

Trial Locations (130)

5000

COMPLETED

GSK Investigational Site, Odense C

8035

RECRUITING

GSK Investigational Site, Barcelona

10016

RECRUITING

GSK Investigational Site, New York

RECRUITING

GSK Investigational Site, New York

11203

COMPLETED

GSK Investigational Site, Brooklyn

11432

RECRUITING

GSK Investigational Site, Jamaica

12208

COMPLETED

GSK Investigational Site, Albany

13273

RECRUITING

GSK Investigational Site, Marseille

14076

RECRUITING

GSK Investigational Site, Caen

15706

RECRUITING

GSK Investigational Site, Santiago de Compostela

17007

RECRUITING

GSK Investigational Site, Girona

19104

RECRUITING

GSK Investigational Site, Philadelphia

19111

RECRUITING

GSK Investigational Site, Philadelphia

20007

COMPLETED

GSK Investigational Site, Washington D.C.

20132

RECRUITING

GSK Investigational Site, Milan

20133

COMPLETED

GSK Investigational Site, Milan

RECRUITING

GSK Investigational Site, Milan

20141

RECRUITING

GSK Investigational Site, Milan

21231

COMPLETED

GSK Investigational Site, Baltimore

22903

RECRUITING

GSK Investigational Site, Charlottesville

26831

COMPLETED

GSK Investigational Site, Hořovice

28027

RECRUITING

GSK Investigational Site, Madrid

28040

RECRUITING

GSK Investigational Site, Madrid

RECRUITING

GSK Investigational Site, Madrid

28046

RECRUITING

GSK Investigational Site, Madrid

28050

RECRUITING

GSK Investigational Site, Madrid

28204

RECRUITING

GSK Investigational Site, Charlotte

29010

RECRUITING

GSK Investigational Site, Málaga

30120

RECRUITING

GSK Investigational Site, Murcia

30912

RECRUITING

GSK Investigational Site, Augusta

31008

RECRUITING

GSK Investigational Site, Pamplona

33076

RECRUITING

GSK Investigational Site, Bordeaux

33136

COMPLETED

GSK Investigational Site, Miami

33612

COMPLETED

GSK Investigational Site, Tampa

35233

RECRUITING

GSK Investigational Site, Birmingham

37134

RECRUITING

GSK Investigational Site, Verona

39008

RECRUITING

GSK Investigational Site, Santander

41013

RECRUITING

GSK Investigational Site, Seville

41100

RECRUITING

GSK Investigational Site, Modena

43026

RECRUITING

GSK Investigational Site, Hilliard

43210

COMPLETED

GSK Investigational Site, Columbus

RECRUITING

GSK Investigational Site, Hilliard

44106

RECRUITING

GSK Investigational Site, Cleveland

44805

RECRUITING

GSK Investigational Site, Saint-Herblain

46009

RECRUITING

GSK Investigational Site, Valencia

46010

RECRUITING

GSK Investigational Site, Valencia

48201

RECRUITING

GSK Investigational Site, Detroit

50009

RECRUITING

GSK Investigational Site, Zaragoza

53226

RECRUITING

GSK Investigational Site, Milwaukee

59000

RECRUITING

GSK Investigational Site, Lille

60637

COMPLETED

GSK Investigational Site, Chicago

61469

RECRUITING

GSK Investigational Site, Gwangju

64111

RECRUITING

GSK Investigational Site, Kansas City

66205

RECRUITING

GSK Investigational Site, Fairway

66278

RECRUITING

GSK Investigational Site, Monterrey

72703

RECRUITING

GSK Investigational Site, Fayetteville

73104

RECRUITING

GSK Investigational Site, Oklahoma City

75230

COMPLETED

GSK Investigational Site, Dallas

75571

RECRUITING

GSK Investigational Site, Paris

75908

RECRUITING

GSK Investigational Site, Paris

78229

COMPLETED

GSK Investigational Site, San Antonio

RECRUITING

GSK Investigational Site, San Antonio

80131

RECRUITING

GSK Investigational Site, Naples

84112

RECRUITING

GSK Investigational Site, Salt Lake City

85258

RECRUITING

GSK Investigational Site, Scottsdale

85338

COMPLETED

GSK Investigational Site, Goodyear

87401

RECRUITING

GSK Investigational Site, Farmington

90095

COMPLETED

GSK Investigational Site, Los Angeles

90403

COMPLETED

GSK Investigational Site, Santa Monica

92024

RECRUITING

GSK Investigational Site, Encinitas

92069

COMPLETED

GSK Investigational Site, San Marcos

92093

COMPLETED

GSK Investigational Site, La Jolla

92663

COMPLETED

GSK Investigational Site, Newport Beach

94115

RECRUITING

GSK Investigational Site, San Francisco

94805

RECRUITING

GSK Investigational Site, Villejuif

98104

RECRUITING

GSK Investigational Site, Seattle

98195

COMPLETED

GSK Investigational Site, Seattle

99202

COMPLETED

GSK Investigational Site, Spokane

99204

RECRUITING

GSK Investigational Site, Spokane

04074

RECRUITING

GSK Investigational Site, Scarborough

02114

RECRUITING

GSK Investigational Site, Boston

02215

RECRUITING

GSK Investigational Site, Boston

02905

RECRUITING

GSK Investigational Site, Providence

75290-9032

RECRUITING

GSK Investigational Site, Dallas

RECRUITING

GSK Investigational Site, Dallas

C1280AEB

RECRUITING

GSK Investigational Site, Ciudad Autonoma de Buenos Aire

X5000HXL

RECRUITING

GSK Investigational Site, Córdoba

X5004FHP

RECRUITING

GSK Investigational Site, Córdoba

14784-400

RECRUITING

GSK Investigational Site, Barretos

90035-000

RECRUITING

GSK Investigational Site, Porto Alegre

14040-030

RECRUITING

GSK Investigational Site, Ribeirão Preto

20231-050

RECRUITING

GSK Investigational Site, Rio de Janeiro

15090-200

RECRUITING

GSK Investigational Site, São José do Rio Preto

01246-000

RECRUITING

GSK Investigational Site, São Paulo

01308-901

RECRUITING

GSK Investigational Site, São Paulo

01321-001

RECRUITING

GSK Investigational Site, São Paulo

T2N 4N2

RECRUITING

GSK Investigational Site, Calgary

T6G 1Z2

RECRUITING

GSK Investigational Site, Edmonton

V1Y 5L3

RECRUITING

GSK Investigational Site, Kelowna

V5Z 4E6

RECRUITING

GSK Investigational Site, Vancouver

L8V 5C2

RECRUITING

GSK Investigational Site, Hamilton

N6A 4L6

RECRUITING

GSK Investigational Site, London

M5G 2M9

RECRUITING

GSK Investigational Site, Toronto

H2L 4M1

RECRUITING

GSK Investigational Site, Montreal

H4A 3J1

RECRUITING

GSK Investigational Site, Montreal

762 75

RECRUITING

GSK Investigational Site, Zlín

DK- 2100

RECRUITING

GSK Investigational Site, Copenhagen

00144

RECRUITING

GSK Investigational Site, Roma

81-519

RECRUITING

GSK Investigational Site, Gdynia

20-090

COMPLETED

GSK Investigational Site, Lublin

10-513

RECRUITING

GSK Investigational Site, Olsztyn

10-561

RECRUITING

GSK Investigational Site, Olsztyn

87-100

RECRUITING

GSK Investigational Site, Torun

02-781

RECRUITING

GSK Investigational Site, Warsaw

463-712

RECRUITING

GSK Investigational Site, Seongnam-si

463 707

RECRUITING

GSK Investigational Site, Seongnam-si Gyeonggi-do

02841

RECRUITING

GSK Investigational Site, Seoul

05505

RECRUITING

GSK Investigational Site, Seoul

08036

RECRUITING

GSK Investigational Site, Barcelona

08907

RECRUITING

GSK Investigational Site, Barcelona

RECRUITING

GSK Investigational Site, Girona

AB25 2ZN

RECRUITING

GSK Investigational Site, Aberdeen

SE1 9RT

RECRUITING

GSK Investigational Site, London

SW3 6JJ

RECRUITING

GSK Investigational Site, London

W1G 6AD

RECRUITING

GSK Investigational Site, London

W1T 7HA

RECRUITING

GSK Investigational Site, London

M20 4BX

COMPLETED

GSK Investigational Site, Manchester

NE7 7DN

COMPLETED

GSK Investigational Site, Newcastle upon Tyne

OX3 7LE

COMPLETED

GSK Investigational Site, Oxford

SW36JJ

RECRUITING

GSK Investigational Site, Sutton

All Listed Sponsors
lead

Tesaro, Inc.

INDUSTRY