Ruxolitinib Phosphate, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

147

Participants

Timeline

Start Date

November 14, 2016

Primary Completion Date

September 30, 2021

Study Completion Date

May 22, 2024

Conditions
Fallopian Tube Clear Cell AdenocarcinomaFallopian Tube Endometrioid AdenocarcinomaFallopian Tube High Grade Serous AdenocarcinomaFIGO Stage III Ovarian Cancer 2014FIGO Stage IIIA Ovarian Cancer 2014FIGO Stage IIIA1 Ovarian CancerFIGO Stage IIIA2 Ovarian CancerFIGO Stage IIIB Ovarian Cancer 2014FIGO Stage IIIC Ovarian Cancer 2014FIGO Stage IVA Ovarian Cancer 2014FIGO Stage IVB Ovarian Cancer 2014Ovarian Clear Cell AdenocarcinomaOvarian Endometrioid AdenocarcinomaOvarian High Grade Serous AdenocarcinomaPrimary Peritoneal Endometrioid AdenocarcinomaPrimary Peritoneal High Grade Serous AdenocarcinomaStage III Fallopian Tube Cancer AJCC v7Stage III Primary Peritoneal Cancer AJCC v7Stage IIIA Fallopian Tube Cancer AJCC v7Stage IIIA Primary Peritoneal Cancer AJCC v7Stage IIIB Fallopian Tube Cancer AJCC v7Stage IIIB Primary Peritoneal Cancer AJCC v7Stage IIIC Fallopian Tube Cancer AJCC v7Stage IIIC Primary Peritoneal Cancer AJCC v7Stage IV Fallopian Tube Cancer AJCC v6 and v7Stage IV Primary Peritoneal Cancer AJCC v7
Interventions
DRUG

Carboplatin

Given IV

DRUG

Paclitaxel

Given IV

DRUG

Ruxolitinib Phosphate

Given PO

PROCEDURE

Therapeutic Conventional Surgery

Undergo TRS

Trial Locations (110)

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

19090

Asplundh Cancer Pavilion, Willow Grove

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Pennsylvania Hospital, Philadelphia

19713

Helen F Graham Cancer Center, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19971

Beebe Health Campus, Rehoboth Beach

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

25304

West Virginia University Charleston Division, Charleston

27157

Wake Forest University Health Sciences, Winston-Salem

30342

Northside Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

31404

Memorial Health University Medical Center, Savannah

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

Summit Cancer Care-Candler, Savannah

34239

Sarasota Memorial Hospital, Sarasota

37232

Vanderbilt University/Ingram Cancer Center, Nashville

40202

Norton Hospital Pavilion and Medical Campus, Louisville

40207

Norton Suburban Hospital and Medical Campus, Louisville

43214

Riverside Methodist Hospital, Columbus

43219

The Mark H Zangmeister Center, Columbus

44024

Geauga Hospital, Chardon

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

45459

Miami Valley Hospital South, Centerville

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

46845

Parkview Regional Medical Center, Fort Wayne

48126

Henry Ford Medical Center-Fairlane, Dearborn

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48377

Henry Ford Medical Center-Columbus, Novi

49007

West Michigan Cancer Center, Kalamazoo

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

49684

Munson Medical Center, Traverse City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60099

Midwestern Regional Medical Center, Zion

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

68114

Nebraska Methodist Hospital, Omaha

68198

University of Nebraska Medical Center, Omaha

70121

Ochsner Medical Center Jefferson, New Orleans

70433

Women's Cancer Care-Covington, Covington

70809

Mary Bird Perkins Cancer Center, Baton Rouge

70817

Woman's Hospital, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75235

Parkland Memorial Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

85338

CTCA at Western Regional Medical Center, Goodyear

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

University of New Mexico Cancer Center, Albuquerque

87124

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho

89106

Women's Cancer Center of Nevada, Las Vegas

90095

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

94115

California Pacific Medical Center-Pacific Campus, San Francisco

95602

Sutter Auburn Faith Hospital, Auburn

95661

Sutter Roseville Medical Center, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

97062

Legacy Meridian Park Hospital, Tualatin

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

98109

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98686

Legacy Salmon Creek Hospital, Vancouver

06810

Danbury Hospital, Danbury

06856

Norwalk Hospital, Norwalk

01605

UMass Memorial Medical Center - Memorial Division, Worcester

07601

Hackensack University Medical Center, Hackensack

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

08876

Robert Wood Johnson University Hospital Somerset, Somerville

02905

Women and Infants Hospital, Providence

29926-3827

South Carolina Cancer Specialists PC, Hilton Head Island

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER