1,002
Participants
Start Date
February 23, 2016
Primary Completion Date
March 15, 2018
Study Completion Date
November 10, 2022
Placebo to Upadacitinib
Tablet; Oral
Methotrexate
Capsule or Tablet; Oral
Placebo to Methotrexate
Capsule or Tablet; Oral
Upadacitinib
Tablet; Oral
Dalin Tzu Chi General Hospital /ID# 153535, Dalin
Univ Medical Ctr Ljubljana /ID# 143667, Ljubljana
Charles Nicolle Univ Hosp /ID# 152866, Tunis
Hospital La Rabta /ID# 152867, Tunis
Clin Especializada Med Interna /ID# 153716, Guatemala City
Clinica Medica Reumatologia /ID# 153714, Guatemala City
Clinica Medica Reumatologia /ID# 153931, Guatemala City
Qualiclinic Kft. /ID# 143259, Budapest
Aprillus Asistencia e Investig /ID# 149179, Capital Federal
Diagnostic Consultative Center /ID# 143174, Sofia
UMHAT Sv. Ivan Rilski /ID# 143175, Sofia
Iari /Id# 148595, San Isidro
HFR Fribourg - Hopital Canton /ID# 143700, Fribourg
Instituto CAICI /ID# 143141, Rosario
Institut Mohamed Kassab /ID# 152869, Manouba
Middlemore Clinical Trials /ID# 143600, Auckland
Hopital Mongi Slim /ID# 152870, La Marsa
Royal Prince Alfred Hospital /ID# 143149, Camperdown
Pest Megyei Flor Ferenc Korhaz /ID# 143260, Kistarcsa
LTD M+M Centers /ID# 143279, Ādaži
Emeritus Research /ID# 143146, Camberwell
Waikato Hospital /ID# 143602, Hamilton
CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 143258, Miskolc
ReumaClinic Genk /ID# 143159, Genk
Centro Integral de Reumatologi /ID# 143143, San Miguel de Tucumán
Centro Medico Privado/Reuma /ID# 143140, San Miguel de Tucumán
MHAT Trimontsium /ID# 143173, Plovdiv
UMHAT Pulmed OOD /ID# 143176, Plovdiv
Hopital Farhat Hached /ID# 152868, Sousse
MHAT Kaspela /ID# 143172, Plovdiv
Rheumatology Research Unit /ID# 143147, Maroochydore
The Queen Elizabeth Hospital /ID# 143148, Woodville
Consultora Integral de Salud S /ID# 143144, Córdoba
Rhumaconsult SPRL /ID# 143158, Charleroi
Southern Clinical Research Pty /ID# 143150, Hobart
CHU Ambroise Pare /ID# 152955, Mons
Porter Rheumatology Ltd /ID# 143601, Nelson
Arthritis Clinical Research Tr /ID# 143670, Cape Town
Winelands Medical Research Ctr /ID# 143669, Stellenbosch
Timaru Medical Specialists Ltd /ID# 143599, Timaru
Fejer Megyei Szent Gyorgy Korh /ID# 144724, Székesfehérvár
Hevizgyogyfurdo es Szent Andra /ID# 143257, Hévíz
UZ Gent /ID# 143157, Ghent
Algemeen Stedelijk Ziekenhuis /ID# 153504, Aalst
Markusovszky Egyetemi Oktatókórház /ID# 143261, Szombathely
Clinical Hospital Dubrava /ID# 143217, Zagreb
Medical Center Kuna-Peric /ID# 143218, Zagreb
Poliklinika Bonifarm /ID# 143215, Zagreb
National Taiwan Univ Hosp /ID# 143702, Taipei City
Creer /Id# 153713, Guatemala City
Center of Clinical and Basic Research /ID# 143239, Tallinn
East Tallinn Central Hospital /ID# 143240, Tallinn
Clinical Center Serbia /ID# 143649, Belgrade
Clinical Center Serbia /ID# 143650, Belgrade
Centro Especializado en Diabetes, Obesidad y Prevención de Enfermedades Cardiova /ID# 143589, Mexico City
CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 153562, Mexico City
University General Hospital Attikon /ID# 143252, Athens
North Estonian Medical Centre /ID# 145456, Tallinn
Comple Hosp Univ de A Coruna /ID# 143672, A Coruña
Advanced Rheumatology & Arthri /ID# 147947, Wexford
Clinica Gaias /ID# 143673, Santiago de Compostela
Hosp Nuestra Senora Esperanza /ID# 143677, Santiago de Compostela
Uludag Universitesi Ataturk Rehabilitasyon ve Uygulama Merkezi /ID# 143705, Osmangazi
Istituto Clinico Humanitas /ID# 147531, Rozzano
Rheumaforschungszentrum II /ID# 143247, Hamburg
Azienda Ospedaliera Luigi Sacc /ID# 143270, Milan
Klinicki bolnicki centar Split /ID# 143216, Split
Special Hospital for Rheuma /ID# 143648, Novi Sad
Vinnytsia Regional Clinical Hospital n.a. M.I.Pyrogov /ID# 143714, Vinnytsia
Schoen Klinikum Hamburg Eilbek /ID# 143251, Hamburg
Arthritis Clinic of N. VA, P.C /ID# 143734, Arlington
Praxis Walter, Rendsburg /ID# 143250, Rendsburg
Fondazione IRCCS Policlinico /ID# 143265, Pavia
Hospital Clin Univ San Carlos /ID# 143674, Madrid
Invest y Biomed de Chihuahua /ID# 143595, Chihuahua City
International Medical Research - Daytona /ID# 143748, Daytona Beach
Millennium Research /ID# 143736, Ormond Beach
FL Med Ctr and Research, Inc. /ID# 143724, Miami
FL Med Clinic, PA /ID# 143744, Zephyrhills
Sarasota Arthritis Center /ID# 145978, Sarasota
Izmir Tepecik Training and Research Hospital /ID# 157863, Konak
Izmir Katip Celebi Ataturk Training & Research Hospital /ID# 143704, Izmir
A.O.U.I. di Verona Policlinico /ID# 143266, Verona
Dr. Ramesh Gupta /ID# 143732, Memphis
West Tennessee Research Inst /ID# 143723, Jackson
H. Un. Marques de Valdecilla /ID# 143671, Santander
China Medical University Hosp /ID# 143703, Taichung
Four Rivers Clinical Research /ID# 143741, Paducah
Rheumazentrum Ruhrgebiet /ID# 145652, Herne
Hosp Lithuanian Univ Health Sc /ID# 143582, Kaunas
Uniklinik Koln /ID# 143248, Cologne
Trinity Health Med Arts Clinic /ID# 143727, Minot
Deerbrook Medical Associates /ID# 143728, Vernon Hills
Odessa National Medical Univ /ID# 143715, Odesa
Zaporizhzhia Regional Clinical /ID# 143712, Zaporizhia
Clinical Center University of Sarajevo /ID# 143164, Sarajevo
Healthcare Research Consultant /ID# 143747, Tulsa
SW Rheumatology Res. LLC /ID# 143745, Mesquite
Regional Clinical Hospital /ID# 152029, Ivano-Frankivsk
Centro Reumatologico de Queret /ID# 149493, Querétaro
Arthritis & Osteoporosis Clinic /ID# 159542, Waco
Rheumatic Disease Clin Res Ctr /ID# 151103, Houston
Accurate Clinical Research /ID# 143749, Houston
Diagnostic Group Integrated He /ID# 152921, Beaumont
University Clinical Centre of the Republic of Srpska /ID# 143161, Banja Luka
University Clinical Centre of the Republic of Srpska /ID# 143162, Banja Luka
Sun Research Institute /ID# 159546, San Antonio
Accurate Clinical Management /ID# 159543, San Antonio
NextGen Clinical Trials LLP /ID# 150930, San Antonio
Barzilai Medical Center /ID# 144725, Ashkelon
Adriana Pop-Moody MD Clinic PA /ID# 147626, Corpus Christi
Doctor's Hosp at Renaissance /ID# 156407, Edinburg
Arthritis Clinic of Central TX /ID# 159541, San Marcos
"MNCE Lviv City Clinical Hospital #4 /ID# 143711", Lviv
Lviv Regional Clinical Hospita /ID# 154449, Lviv
Revmatologie Bruntal, s.r.o /ID# 143220, Bruntál
MedResearch Inc. /ID# 156409, El Paso
Ctr Int de Reum del Caribe SAS /ID# 143211, Barranquilla
Paernu Hospital /ID# 143238, Pärnu
LMU Klinikum der Universität München /ID# 143249, Munich
MEDEOS s.r.o. /ID# 143656, Trenčín
REUMA-GLOBAL, s.r.o. /ID# 143655, Trnava
TriWest Research Associates- La Mesa /ID# 143738, La Mesa
Desert Medical Advances /ID# 143730, Palm Desert
Klaipeda University Hospital /ID# 143583, Klaipėda
Karaganda State Medical Univ /ID# 153431, Karaganda
Centro de Investigacion en Reumatologia y Especialidades Medicas- CIREEM SAS /ID# 143214, Bogota
Riesgo de Fractura S.A - CAYRE /ID# 143212, Bogotá
Simedics IPS SAS /ID# 152572, Bogotá
Russian National Research Medi /ID# 143642, Moscow
Clinical Hospital No.1 n.a. N.I.Pirogov /ID# 143641, Moscow
Family Outpatient clinic#4,LLC /ID# 151010, Korolev
Regional Clinical Hospital /ID# 147173, Shymkent
Tver Regional Clinical Hosp. /ID# 143639, Tver'
Republican Clin Hos n.a. Baran /ID# 143634, Petrozavodsk
First City Clinical Hospital /ID# 159020, Minsk
City Clinical Hospital #9 /ID# 145650, Minsk
1st Aff Hosp of Bengbu Med Col /ID# 162974, Bengbu
LLC Novaya Klinika /ID# 143631, Pyatigorsk
The 1st Aff Hosp Xiamen Univ /ID# 162076, Xiamen
Ryazan State Medical Universit /ID# 143646, Ryazan
Voronezh State Medical Univers /ID# 150926, Voronezh
Ecomed SRL /ID# 143629, Oradea
Kazan State Medical University /ID# 143645, Kazan'
Ulyanovsk Regional Clin Hosp /ID# 143644, Ulyanovsk
Samara Regional Clinical Hosp /ID# 150928, Samara
Reg Clin Hosp n.a. Kuvatova G. /ID# 143632, Ufa
Orenburg Regional Clinical Hos /ID# 143630, Orenburg
1st Aff Hosp of Shantou Univ /ID# 162968, Shantou
LLC Medical Center /ID# 143647, Novosibirsk
Medicity S.A.S. /ID# 143213, Bucaramanga
Spitalul Clinic de Recuperare /ID# 143620, Iași
Queen Mary Hospital /ID# 143255, Hong Kong
Tuen Mun Hospital /ID# 143256, Tuenmen
Toho University Ohashi Medical Center /ID# 148027, Meguro-ku
Rambam Health Care Campus /ID# 143263, Haifa
Ctr de Inv Clinica del Sur /ID# 143208, Temuco
Sheba Medical Center /ID# 145975, Ramat Gan
Quantum Research LTDA. /ID# 143210, Puerto Varas
Japanese Red Cross Okayama Hospital /ID# 159619, Okayama
Quantum Research Stgo. /ID# 145651, Santiago
Soc. de Prestaciones medicas y Paramedicas Goecke /ID# 143209, Santiago
Someal /Id# 143207, Providencia
Investigaciones Medicas SSMSO /ID# 151685, Santiago
Kumamoto Shinto General Hospital /ID# 148266, Kumamoto
Arthritis Research of Florida /ID# 143743, Palm Harbor
Ocean Rheumatology, PA /ID# 143737, Toms River
Arthritis Rheumatic Back Disorder /ID# 143733, Voorhees Township
STAT Research, Inc. /ID# 143750, Vandalia
Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 145653, Summerville
Org Medica de Investigacion /ID# 143142, Buenos Aires
CIP - Centro Internacional de Pesquisa /ID# 143171, Goiânia
Ceti - Centro de Estudos Em Terapias Inovadoras Ltda /Id# 143169, Curitiba
Hospital de Clinicas de Porto Alegre /ID# 143168, Porto Alegre
LMK Sevicos Medicos S/S /ID# 143167, Porto Alegre
CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos Ltda /ID# 143166, São Paulo
CCBR Brasil /ID# 150925, Rio de Janeiro
Rheumatology Research Assoc /ID# 143206, Edmonton
Manitoba Clinic /ID# 143203, Winnipeg
Ciads /Id# 143205, Winnipeg
CA Ctr for Clin Trials CCCT /ID# 159080, Thornhill
Ctr. de Rheum de l'est du QC /ID# 151317, Rimouski
Centro de Estudios Clinicos Qu /ID# 152913, Viña del Mar
Fund Inst de Reum F. Chalem /ID# 159544, Bogotá
L.K.N. Arthrocentrum, s.r.o /ID# 143224, Hlučín
CTCenter MaVe, s.r.o. /ID# 143226, Olomouc
Nuselská poliklinika, Revmatologie /ID# 143232, Prague
Nuselská poliklinika, Revmatologie /ID# 143233, Prague
Thomayerova nemocnice /ID# 143228, Prague
PV MEDICAL Services s.r.o. /ID# 143234, Zlín
Revmatologie, s.r.o. /ID# 143223, Brno
RHEUMA s.r.o. /ID# 143230, Břeclav
Nemocnice Slany /ID# 143221, Slaný
Medical Plus, s.r.o. /ID# 143219, Uherské Hradište
Clinicas Hospital Herrera Ller /ID# 153715, Guatemala City
St Vincent's University Hosp /ID# 143262, Dublin
Nagoya University Hospital /ID# 148031, Nagoya
NHO Toyohashi Medical Center /ID# 161033, Toyohashi
Teikyo University Chiba Medical Center /ID# 159618, Ichihara
NHO Kyushu Medical Center /ID# 148263, Fukuoka
NHO Kyushu Medical Center /ID# 148264, Fukuoka
National Hospital Organization Asahikawa Medical Center /ID# 148021, Asahikawa
Katayama Orthopedic Rheumatology Clinic /ID# 148029, Asahikawa
Kobe University Hospital /ID# 153461, Kobe
National Hospital Organization Sagamihara National Hospital /ID# 148019, Sagamihara-shi
NHO Osaka Minami Med Ctr /ID# 148042, Osaka
Bay Side Misato Medical Center /ID# 148256, Kochi
Center for Arthritis and Clinical Rheumatology Matsubara Clinic /ID# 148254, Kumamoto
Kumamoto Orthopaedic Hospital /ID# 148054, Kumamoto
Sasebo Chuo Hospital /ID# 148261, Sasebo
Nagaoka Red Cross Hospital /ID# 148018, Nagaoka-shi
Kansai Medical University Hospital /ID# 159622, Hirakata-shi
Osaka Medical College Hospital /ID# 159624, Takatsuki -shi
Saitama Medical Center, Saitama Medical University /ID# 148015, Kawagoe-shi
Jichi Medical University Hospital /ID# 159620, Shimotsuke-shi
Juntendo University Hospital /ID# 148050, Bunkyo-ku
St.Luke's International Hospital /ID# 148041, Chuo-ku
Keio University Hospital /ID# 148057, Shinjuku-ku
Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 148052, Shimonoseki-shi
National Hospital Organization Beppu Medical Center /ID# 161058, Beppu
NHO Chiba-East-Hospital /ID# 148035, Chiba
Sugimoto Rheumatology and Internal Medicine Clinic /ID# 148047, Fukui
Shono Rheumatism Clinic /ID# 148046, Fukuoka
Matsubara Mayflower Hospital /ID# 148033, Katō
St. Mary's Hospital /ID# 148038, Kurume
Kagawa University Hospital /ID# 148016, Kyoto
Yu Family Clinic /ID# 148048, Miyagi
Daido Hospital /ID# 160868, Nagoya
Kondo Clinic for Ortho & Rheum /ID# 148032, Nagoya
Shirahama Hamayu Hospital /ID# 148253, Nishimura
Osaka City General Hospital /ID# 159617, Osaka
Oribe Clinic of Rheumatology and Internal Medicine /ID# 156035, Ōita
Sanuki Municipal Hospital /ID# 158842, Sanuki
Sagawa Akira Rheumatology Clin /ID# 148043, Sapporo
Sapporo City General Hospital /ID# 148037, Sapporo
Hokkaido University Hospital /ID# 148262, Sapporo
Hokkaido Medical Center for Rheumatic Diseases /ID# 148259, Sapporo
Azuma Rheumatology Clinic /ID# 161050, Sayama
Hikarigaoka Spellman Hospital /ID# 148020, Sendai
Takaoka Rheumatic Orthopedic Clinic /ID# 148022, Takaoka
National Hospital Organization Tokyo Medical Center /ID# 148040, Tokyo
National Hospital Organization Shimoshizu National Hospital /ID# 148258, Yotsukaidō
JSC Nat Scientific Med Res Ctr /ID# 143272, Astana
Semey State Medical University /ID# 152661, Semey
Vilnius University Hospital /ID# 143584, Vilnius
Clinstile, S.A. de C.V. /ID# 143591, Cuauhtémoc
RM Pharma Specialists, S.A de C.V /ID# 143593, Mexico City
Unidad de Investigacion de las Enfermedades Reumatologicas SA de CV /ID# 143592, Mexico City
Medyczne Centrum Hetmanska /ID# 144726, Poznan
WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 143606, Wroclaw
Centrum Medyczne AMED /ID# 143604, Warsaw
Centrum Medyczne Pratia Warszawa /ID# 143608, Warsaw
Centrum Medyczne Pratia Gdynia /ID# 143607, Gdynia
Silmedic Sp z o.o /ID# 143605, Katowice
NZOZ Centrum Reumatologiczne /ID# 143603, Elblag
Instituto Portugues De Reumatologia /ID# 148313, Lisbon
Centro Hospitalar Lisboa Ocidental, EPE /ID# 151009, Lisbon
Centro Hospitalar De Vila Nova /ID# 143615, Vila Nova de Gaia
Centro Hospitalar Lisboa Norte, EPE /ID# 143613, Lisbon
Centro Hospitalar Baixo Vouga /ID# 153726, Porto
Centro Hospitalar de Sao Joao, EPE /ID# 153575, Porto
Unidade Local De Saude Do Alto Minho /ID# 143611, Viana do Castelo
Centro Hosp de Tondela-Viseu /ID# 143612, Viseu
Ponce School of Medicine /ID# 145657, Ponce
GCM Medical Group /ID# 143618, San Juan
School of Medicine University of Puerto Rico-Medical Sciences Campus /ID# 143619, San Juan
Spitalul Clinic Dr. I. Cantacuzino /ID# 143622, Bucharest
Spitalul Clinic Sf. Maria /ID# 143623, Bucharest
Spitalul Clinic Sf. Maria /ID# 143625, Bucharest
Spitalul Clinic Sf. Maria /ID# 143627, Bucharest
MEDMAN s.r.o. /ID# 143661, Martin
Reumatologická ambulancia Reum.hapi s.r.o. /ID# 143657, Nové Mesto nad Váhom
REUMACENTRUM s.r.o. /ID# 143653, Partizánske
Slovak research center Team Member, Thermium s.r.o. /ID# 143663, Pieštany
Slovak Research Center /ID# 143659, Púchov
TIMMED spol. s r.o. /ID# 143664, Stará Lubovna
Reumatologicka ambulancia, LER /ID# 143660, Topoľčany
ALBAMED s.r.o. /ID# 143654, Zvolen
Reuma -MUDr. Maria Palasthyova /ID# 143662, Žiar nad Hronom
Jakaranda Hosp, Emmed Research /ID# 143668, Pretoria
Jakaranda Hosp, Emmed Research /ID# 145976, Pretoria
Hospital Univ Vall d'Hebron /ID# 143675, Barcelona
NSC-Strazhesko Ist Cardiology /ID# 152026, Kiev
LLC Revmocentr /ID# 143710, Kyiv
Leicester Royal Infirmary /ID# 143718, Leicester
Whipps Cross Univ Hospital /ID# 143721, London
Western General Hospital /ID# 144431, Edinburgh
Chapel Allerton Hospital /ID# 143717, Leeds
Queen Alexandra Hospital /ID# 143722, Portsmouth
Southampton General Hospital /ID# 143716, Southampton
Lead Sponsor
AbbVie
INDUSTRY