A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs

PHASE3CompletedINTERVENTIONAL
Enrollment

499

Participants

Timeline

Start Date

March 15, 2016

Primary Completion Date

April 3, 2017

Study Completion Date

February 8, 2022

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Placebo

Tablet; Oral

DRUG

Upadacitinib

Tablet; Oral

Trial Locations (188)

1027

Revita Reumatologiai Rendelo /ID# 142590, Budapest

1090

Medizinische Universität Wien /ID# 142424, Vienna

1100

Rheuma Zentrum Favoriten GmbH /ID# 142421, Vienna

Rheuma-Zentrum Wien-Oberlaa /ID# 142425, Vienna

1160

Wilhelminenspital der Stadt Wien /ID# 142422, Vienna

1200

Cliniques Universitaires Saint Luc /ID# 142426, Woluwe-Saint-Lambert

1708

HFR Fribourg - Hopital Canton /ID# 142723, Fribourg

2164

LTD M+M Centers /ID# 142624, Ādaži

3124

Emeritus Research /ID# 142416, Camberwell

3600

ReumaClinic Genk /ID# 142431, Genk

4031

Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 142587, Debrecen

Universitaetsspital Basel /ID# 145610, Basel

5011

The Queen Elizabeth Hospital /ID# 142419, Woodville

5700

Bekes Megyei Pandy Kalman Korh /ID# 142588, Gyula

6000

Rhumaconsult SPRL /ID# 151378, Charleroi

7910

Timaru Medical Specialists Ltd /ID# 142657, Timaru

8036

Universitaetsklinik fuer Inner /ID# 142423, Graz

8200

Vital Medical Center Orvosi es /ID# 142586, Veszprém

8400

AZ Damiaan /ID# 142427, Ostend

9000

UZ Gent /ID# 142429, Ghent

10117

Charité Universitätsmedizin Campus Mitte /ID# 142559, Berlin

10138

East Tallinn Central Hospital /ID# 142543, Tallinn

11040

North Shore University Hospital /ID# 142772, New Hyde Park

12206

The Center for Rheumatology /ID# 142784, Albany

14127

Buffalo Rheumatology /ID# 142766, Orchard Park

15006

Comple Hosp Univ de A Coruna /ID# 142708, A Coruña

15702

Clinica Gaias /ID# 142709, Santiago de Compostela

15850

Paijat-Hame Central Hospital /ID# 149185, Lahti

18015

East Penn Rheumatology Assoc /ID# 142790, Bethlehem

19610

Clinical Research Ctr Reading /ID# 151714, Wyomissing

19958

Delaware Arthritis /ID# 142803, Lewes

20095

Rheumaforschungszentrum II /ID# 142560, Hamburg

20902

The Center for Rheumatology & /ID# 142742, Wheaton

22081

Schoen Klinikum Hamburg Eilbek /ID# 142566, Hamburg

22332

Inha University Hospital /ID# 150881, Incheon

22763

Asklepios Klinik Altona /ID# 142561, Hamburg

25309

West Virginia Research Inst /ID# 153087, South Charleston

27617

Shanahan Rheuma & Immuno /ID# 142812, Raleigh

28040

Hospital Clin Univ San Carlos /ID# 142711, Madrid

28204

Joint & Muscle Research Instit /ID# 142797, Charlotte

28451

Cape Fear Arthritis Care /ID# 148344, Leland

28562

Coastal Carolina Health Care /ID# 148351, New Bern

29009

Hospital Regional de Malaga /ID# 142707, Málaga

29204

Columbia Arthritis Center /ID# 153728, Columbia

30033

Jefrey D. Lieberman, MD, P.C. /ID# 151713, Decatur

30060

Marietta Rheumatology Assoc /ID# 151347, Marietta

31059

Hopital Universitaire Purpan /ID# 144697, Toulouse

32174

Millennium Research /ID# 142782, Ormond Beach

32810

Omega Research Consultants /ID# 142780, Orlando

33014

Lakes Research, LLC /ID# 142755, Miami

33076

CHU Bordeaux-Hopital Pellegrin /ID# 144700, Bordeaux

33612

University of South Florida /ID# 145611, Tampa

33705

St. Anthony Comprehsve Res Ins /ID# 148349, St. Petersburg

33781

Advent Clinical Research /ID# 142817, Pinellas Park

34102

Medallion Clinical Research Institute, LLC /ID# 142740, Naples

34292

Lovelace Scientific Resources /ID# 142779, Venice

34295

Hopital Saint Eloi /ID# 142552, Montpellier

34684

Arthritis Center, Inc. /ID# 142822, Palm Harbor

35801

Rheum Assoc of North Alabama /ID# 145959, Huntsville

37660

Arthritis Associates, PLLC /ID# 142774, Kingsport

Arthritis Associates, PLLC /ID# 155462, Kingsport

38119

Dr. Ramesh Gupta /ID# 142767, Memphis

38305

West Tennessee Research Inst /ID# 142739, Jackson

38801

North Mississippi Med Clinics /ID# 142781, Tupelo

39008

H. Un. Marques de Valdecilla /ID# 142706, Santander

44649

Rheumazentrum Ruhrgebiet /ID# 145600, Herne

45067

CHR Orleans - Hopital de la Source /ID# 142557, Orléans

46005

Centre Hospitalier Jean Rougie /ID# 142556, Cahors

46026

Hospital Universitario La Fe /ID# 142716, Valencia

48910

June DO, PC /ID# 142756, Lansing

50406

MediTrials /ID# 151777, Tartu

50937

Uniklinik Koln /ID# 142563, Cologne

53132

Aurora Rheumatology and Immunotherapy Center /ID# 142820, Franklin

55139

Ondokuz mayis University Facul /ID# 142728, Samsun

58701

Trinity Health Med Arts Clinic /ID# 142754, Minot

60061

Deerbrook Medical Associates /ID# 151712, Vernon Hills

60076

Clinical Investigation Special /ID# 149270, Skokie

60640

Great Lakes Clinical Trials /ID# 148341, Chicago

66346

Knappschaftsklinikum Saar /ID# 142562, Püttlingen

68114

Westroads Clinical Research /ID# 142802, Omaha

69437

Hopital Edouard Herriot /ID# 144698, Lyon

70185

Orebro Universitetssjukhuset /ID# 142718, Örebro

71011

Vanguard Medical Research, LLC /ID# 153123, Shreveport

71203

The Arthritis & Diabetes Clinic, Inc. /ID# 142793, Monroe

72037

Centre Hospitalier Le Mans /ID# 145956, Le Mans

72189

Vastmanlands Sjukhus /ID# 142721, Västerås

72401

NEA Baptist Clinic /ID# 149280, Jonesboro

74135

Healthcare Research Consultant /ID# 142815, Tulsa

75150

SW Rheumatology Res. LLC /ID# 142813, Mesquite

75231

Arthritis Care and Diagnostic /ID# 151344, Dallas

Metroplex Clinical Research /ID# 142758, Dallas

76710

Arthritis & Osteoporosis Clinic /ID# 142760, Waco

77004

Rheumatic Disease Clin Res Ctr /ID# 150914, Houston

77065

Rheumatology Clinic of Houston /ID# 150915, Houston

77074

Houston Institute for Clin Res /ID# 142768, Houston

77375

DM Clinical Research /ID# 151007, Tomball

77701

Diagnostic Group Integrated He /ID# 148340, Beaumont

77845

Arth and Osteo Clin Brazo Valley /ID# 148343, College Station

78232

Arthritis & Osteo Ctr of S. TX /ID# 142773, San Antonio

78666

Arthritis Clinic of Central TX /ID# 148346, San Marcos

78745

Tekton Research, Inc. /ID# 142805, Austin

79424

Arthritis & Osteoporosis Assoc /ID# 147567, Lubbock

80230

Denver Arthritis Clinic /ID# 142771, Denver

80337

LMU Klinikum der Universität München /ID# 142564, Munich

80920

Arthritis Assoc & Osteo Ctr /ID# 142809, Colorado Springs

82152

MVZ Planegg /ID# 142565, Planegg

83404

Institute of Arthritis Res /ID# 142810, Idaho Falls

83642

Advanced Clinical Research /ID# 153089, Meridian

83702

St. Luke's Clinic - Rheumatolo /ID# 150923, Boise

85202

AZ Arthritis and Rheum Assoc /ID# 148593, Mesa

85351

AZ Arthritis & Rheum Research /ID# 156090, Sun City

86305

AZ Arthr & Rheum Research /ID# 155256, Prescott

90045

Pacific Arthritis Ctr Med Grp /ID# 142783, Los Angeles

90095

University of California, Los Angeles /ID# 148348, Los Angeles

90606

Medvin Clinical Research /ID# 142814, Whittier

91722

Covina Arthritis Clinic /ID# 142794, Covina

91786

Inland Rheum Clin Trials Inc. /ID# 142787, Upland

91942

TriWest Research Associates- La Mesa /ID# 142792, La Mesa

92025

Rheumatology Ctr of San Diego /ID# 153576, Escondido

92260

Desert Medical Advances /ID# 142765, Palm Desert

92780

Robin K. Dore MD, Inc /ID# 150908, Tustin

92835

St. Joseph Heritage Healthcare /ID# 149273, Fullerton

98021

Western Washington Arthritis C /ID# 142776, Bothell

98664

The Vancouver Clinic, INC. PS /ID# 147946, Vancouver

99204

Arthritis Northwest, PLLC /ID# 150924, Spokane

141060

Family Outpatient clinic#4,LLC /ID# 150910, Korolev

3339419

Bnai Zion Medical Center /ID# 151945, Haifa

3436212

The Lady Davis Carmel MC /ID# 142599, Haifa

6423906

Tel Aviv Sourasky Medical Ctr /ID# 142597, Tel Aviv

85032-9306

AZ Arthritis and Rheum Researc /ID# 142816, Phoenix

AZ Arthritis and Rheum Researc /ID# 146075, Phoenix

AZ Arthritis and Rheum Researc /ID# 148592, Phoenix

85053-4061

Arizona Research Center, Inc. /ID# 142741, Phoenix

90623-1728

Arthritis & Osteo Medical Ctr /ID# 142770, La Palma

90720-5402

Valerius Med Grp & Res Ctr /ID# 142799, Los Alamitos

94305-2200

Stanford University School of Med /ID# 142761, Stanford

06606-1827

New England Research Associates, LLC /ID# 142763, Bridgeport

34684-2672

Arthritis Research of Florida /ID# 142811, Palm Harbor

33614-7101

BayCare Medical Group, Inc. /ID# 142747, Tampa

62702-3749

Springfield Clinic /ID# 142818, Springfield

04102

MMP Women's Health /ID# 145612, Portland

02048

Mansfield Health Center /ID# 147628, Mansfield

01605

Clinical Pharmacology Study Gr /ID# 142744, Worcester

63119-3845

Clayton Medical Associates dba Saint Louis Rheumatology /ID# 142745, St Louis

63139-2338

Barbara Caciolo, MD /ID# 142749, St Louis

03756

Dartmouth-Hitchcock Medical Center /ID# 145958, Lebanon

08755

Atlantic Coast Research /ID# 148347, Toms River

Ocean Rheumatology, PA /ID# 142785, Toms River

28210-8508

DJL Clinical Research, PLLC /ID# 142769, Charlotte

45242-4468

Cincinnati Rheumatic Disease Study Group, Inc. /ID# 142791, Cincinnati

45377-9464

STAT Research, Inc. /ID# 142821, Vandalia

73103-2400

Health Research Oklahoma /ID# 142751, Oklahoma City

77030-3411

Baylor College of Medicine /ID# 142753, Houston

77098-5294

Pioneer Research Solutions, Inc. /ID# 151346, Houston

75904-3132

P&I Clinical Research /ID# 151345, Lufkin

75024-5283

Trinity Universal Research Association /ID# 149278, Plano

R3N 0K6

Ciads /Id# 142526, Winnipeg

702 00

Revmatologie MUDr. Klara Sirova /ID# 142536, Ostrava

686 01

Medical Plus, s.r.o. /ID# 148345, Uherské Hradište

05800

Kiljava Medical Research /ID# 142546, Hyvinkää

115 27

General Hospital of Athens Laiko /ID# 142579, Athens

D04 T6F4

St Vincent's University Hosp /ID# 142593, Dublin

LV-1002

P. Stradins Clinical Univ Hosp /ID# 142623, Riga

LV-1050

Arthritis Clinic Ltd /ID# 153560, Riga

30-510

Pratia MCM Krakow /ID# 142664, Krakow

51-685

WroMedica I. Bielicka, A. Strzalkowska s.c. /ID# 142665, Wroclaw

01-869

Centrum Medyczne Pratia Warszawa /ID# 142667, Warsaw

03-291

Centrum Medyczne AMED Warszawa Targowek /ID# 142663, Warsaw

81-338

Centrum Medyczne Pratia Gdynia /ID# 142666, Gdynia

4434-502

Centro Hospitalar De Vila Nova /ID# 142670, Vila Nova de Gaia

1649-035

Centro Hospitalar Lisboa Norte, EPE /ID# 142668, Lisbon

00909

GCM Medical Group /ID# 142671, San Juan

040 11

ARTROMAC n.o. /ID# 142692, Košice

040 15

Nemocnica Kosice Saca, a.s. /ID# 142693, Košice

921 12

Narodny ustav reumatickych chorob Piestany /ID# 142691, Pieštany

04763

Hanyang University Seoul Hospi /ID# 150883, Seoul

03080

Seoul National University Hospital /ID# 142622, Seoul

413 45

Sahlgrenska University Hosp /ID# 142720, Gothenburg

302 33

Capio Movement Halmstad /ID# 148236, Halmstad

06100

Hacettepe University Medical Faculty /ID# 142729, Ankara

06800

Ankara Ataturk Training & Res /ID# 142727, Ankara

E11 1NR

Whipps Cross Univ Hospital /ID# 145957, London

NW3 2QG

The Royal Free Hospital /ID# 142733, London

CM1 7ET

Mid Essex Hospitals NHS Trust /ID# 148992, Chelmsford

EH4 2XU

Western General Hospital /ID# 142732, Edinburgh

IP33 2QZ

West Suffolk Hospital /ID# 148993, Ipswich

CH49 5PE

Arrowe Park Hospital /ID# 148991, Metropolitan Borough of Wirral

PO6 3LY

Queen Alexandra Hospital /ID# 142735, Portsmouth

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY