NCT02699060 - Experimental Study to Determine the Effects of Human Refluxate on Macrophage Phenotype and Its Correlation With GERD | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

February 29, 2016

Primary Completion Date

January 31, 2019

Study Completion Date

January 31, 2019

Conditions

Gastroesophageal Reflux Disease (GERD)

Interventions

PROCEDURE

Upper gastrointestinal endoscopy with biopsy and collection of refluxate

we analyzed esophageal mucosa, expression of inflammatory changes, location, size, number of mucosal defects, as well as the appearance of the gastric and duodenal mucosa.

PROCEDURE

Esophageal high-resolution manometry and 24-h esophageal pH-impedance monitoring

we analyzed following HRM parameters: the distal contractile integral (DCI), the lower esophageal sphincter resting pressure (LES RP) and standard measuring parameters were be collected: percentage of total time when pH was \<4, longest reflux event, number of reflux events longer than 5 minutes, and number of reflux episodes in 24 hours.

Trial Locations (2)

119991

I.M.Sechenov First Moscow State Medical University, Moscow

127473

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow