Ibrutinib in Patients With Refractory/Relapsed Non-GCB Diffuse Large B-cell Lymphoma Non-candidates to ASCT

PHASE2CompletedINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

April 7, 2016

Primary Completion Date

November 8, 2018

Study Completion Date

January 19, 2021

Conditions
Diffuse Large B-Cell Lymphoma
Interventions
DRUG

Ibrutinib

Ibrutinib 560 mg daily for 14 days during induction cycles. Maintenance phase: Continuous cycles until disease progression or unacceptable toxicity (maximum of 2 years).

DRUG

Rituximab

Rituximab 375 mg/m2 IV day 1 during 4 cycles.

DRUG

Gemcitabine

Gemcitabine 1000 mg/m2 IV (30-minute infusion) on day 1 or 2, 4 cycles every 14 days.

DRUG

Oxaliplatin

Oxaliplatin 100 mg/m2 (3-hour infusion) on day 1 or 2, after Gemcitabine infusion, 4 cycles every 14 days.

DRUG

Dexamethasone

Dexamethasone 20 mg orally or IV on day 1 and orally on days 2-3, 4 cycles every 14 days.

Trial Locations (17)

11407

Hospital Especialidades, Jerez de la Frontera

20080

Hospital Universitario Donostia, Donostia / San Sebastian

23007

Complejo Hospitalario de Jaén, Jaén

28031

Hospital Universitario Infanta Leonor, Madrid

28033

MD Anderson Cancer Center, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

30008

Hospital General Universitario Morales Meseguer, Murcia

31008

Hospital de Navarra, Pamplona

33011

Hospital Universitario Central de Asturias, Oviedo

41013

Hospital Universitario Virgen del Rocío, Seville

46010

Hospital Clínic Universitari de València, Valencia

46026

Hospital Universitario y Politécnico La Fe, Valencia

47005

Hospital Clínico Universitario de Valladolid, Valladolid

07120

Hospital Universitario Son Espases, Palma

Unknown

Complexo Hospitalario Universitario de Vigo, Vigo

08035

Hospital Universitario Vall d'Hebron, Barcelona

08036

Hospital Clínic de Barcelona, Barcelona

All Listed Sponsors
collaborator

Janssen-Cilag, S.A.

INDUSTRY

lead

Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea

OTHER

NCT02692248 - Ibrutinib in Patients With Refractory/Relapsed Non-GCB Diffuse Large B-cell Lymphoma Non-candidates to ASCT | Biotech Hunter | Biotech Hunter