Management of Castration-Resistant Prostate Cancer with Oligometastases

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

102

Participants

Timeline

Start Date

October 31, 2016

Primary Completion Date

April 30, 2027

Study Completion Date

August 31, 2041

Conditions
Castration-resistant Prostate Cancer Patients with Oligometastases
Interventions
DRUG

Leuprolide Acetate

Luteinizing hormone releasing hormone (LHRH) agonist administered by subcutaneous injection. Only one of the LHRH agonists described here will be administered during the course of treatment.

DRUG

Goserelin Acetate

Luteinizing hormone releasing hormone (LHRH) agonist administered by subcutaneous injection. Only one of the LHRH agonists described here will be administered during the course of treatment.

DRUG

Triptorelin

Luteinizing hormone releasing hormone (LHRH) agonist administered by subcutaneous injection. Only one of the LHRH agonists described here will be administered during the course of treatment.

DRUG

Enzalutamide

Anti-androgen medication for the treatment of metastatic castration-resistant prostate cancer. 160 mg (four 40 mg capsules) taken as a single oral daily dose, with or without food, until disease progression.

RADIATION

Stereotactic Body Radiation Therapy

Stereotactic body radiation therapy (SBRT) is a treatment modality in radiation oncology that delivers a very high dose of radiation to the tumour target with high precision using a single or a small number of fractions.

Trial Locations (11)

V5Z 4E6

BC CANCER Vancouver, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

B3H 1V7

Nova Scotia Cancer Centre, Halifax

L8V 5C2

Juravinski Cancer Centre, Hamilton

N6A 5W9

London Regional Cancer Program - London Health Sciences Centre, London

J4V2H1

Hopital Charles-Lemoyne, Longueuil

H2L 4M1

Centre Hospitalier de l'Université de Montréal (CHUM) - Hopital Notre Dame, Montreal

H3T 1E2

Jewish General Hospital, McGill University, Montreal

H4A 3J1

McGill University Health Center, Montreal

G1R 2J6

CHU de Quebec-Universite Laval, Québec

G8Z 3R9

Centre Hospitalier régional de Trois-Rivières, Trois-Rivières

All Listed Sponsors
lead

Sir Mortimer B. Davis - Jewish General Hospital

OTHER

NCT02685397 - Management of Castration-Resistant Prostate Cancer with Oligometastases | Biotech Hunter | Biotech Hunter