Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF)

PHASE4CompletedINTERVENTIONAL
Enrollment

119

Participants

Timeline

Start Date

October 21, 2016

Primary Completion Date

February 13, 2020

Study Completion Date

February 13, 2020

Conditions
Cystic Fibrosis
Interventions
DRUG

azithromycin

500mg tablet over-encapsulated to match placebo

DRUG

placebo (for azithromycin)

DRUG

inhaled tobramycin

clinically prescribed inhaled tobramycin used by subjects participating in the study

Trial Locations (39)

10003

Beth Israel Medical Center, New York

10032

Children's Hospital of New York, New York

14642

University of Rochester Medical Center Strong Memorial, Rochester

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

Hershey Medical Center Pennsylvania State University, Hershey

19134

St. Christopher's Hospital for Children, Philadelphia

21287

Johns Hopkins University, Baltimore

27599

University of North Carolina at Chapel Hill, Chapel Hill

32504

Nemours Children's Clinic - Pensacola, Pensacola

32610

University of Florida, Gainesville

32806

The Nemours Children's Clinic - Orlando, Orlando

44106

University Hospitals Case Medical Center/Rainbow Babies and Children's Hospital, Cleveland

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

Dayton Children's Hospital, Dayton

46202

Riley Hospital for Children, Indianapolis

48109

University of Michigan Health System, Ann Arbor

49503

Helen DeVos Children's Hospital, Grand Rapids

53226

Children's Hospital of Wisconsin, Milwaukee

55455

The Minnesota Cystic Fibrosis Center, Minneapolis

60208

Northwestern University, Chicago

61637

Saint Francis Medical Center, Peoria

63104

Cardinal Glennon Children's Medical Center, St Louis

63110

St. Louis Children's Hospital, St Louis

64108

Children's Mercy Kansas City, Kansas City

76104

Cook Children's Medical Center, Fort Worth

80206

National Jewish Health, Denver

83712

Saint Luke's Cystic Fibrosis Center of Idaho, Boise

84113

Intermountain Cystic Fibrosis Center, Salt Lake City

90027

Children's Hospital of Los Angeles, Los Angeles

92123

Rady Children's Hospital and Health Center at the University of California San Diego, San Diego

94025

Stanford University Medical Center, Palo Alto

97239

Oregon Health Sciences University, Portland

98145

Seattle Children's Hospital, Seattle

98195

University of Washington Medical Center, Seattle

06520

Yale University School of Medicine, New Haven

04102

Maine Medical Partners Pediatric Specialty Care, Portland

02115

Boston Children's Hospital, Boston

01655

University of Massachusetts Memorial Health Care, Worcester

07740

Monmouth Medical Center, Long Branch

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Cystic Fibrosis Foundation

OTHER

collaborator

CF Therapeutics Development Network Coordinating Center

NETWORK

lead

Seattle Children's Hospital

OTHER

NCT02677701 - Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF) | Biotech Hunter | Biotech Hunter