Efficacy and Safety Study of ATG for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT

PHASE4CompletedINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

January 31, 2016

Primary Completion Date

January 31, 2020

Study Completion Date

April 30, 2022

Conditions
aGVHD
Interventions
DRUG

ATG

rabbit ATG(Sanofi)

DRUG

CsA

cyclosporine (3 mg/kg, q12h, i.v.) was used from day -9, and the concentration was adjusted to 180-200 ng/mL. CsA was switched to oral administration when the patient's bowel function recovered.

DRUG

mycophenolate mofetil

From day -9, 0.5 g of mycophenolate mofetil was administered orally from every 12 h, which was withdrawn on day +30 for MSD-PBSCT.

DRUG

Methotrexate

short-term methotrexate

Trial Locations (1)

100853

Liping Dou, Beijing

All Listed Sponsors
collaborator

309th Hospital of Chinese People's Liberation Army

OTHER

collaborator

Beijing Naval General Hospital

OTHER

collaborator

Space Center Hospital, Peking University

UNKNOWN

lead

Chinese PLA General Hospital

OTHER

NCT02677181 - Efficacy and Safety Study of ATG for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT | Biotech Hunter | Biotech Hunter