A Study Comparing Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on a Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response to csDMARDs Alone

PHASE3CompletedINTERVENTIONAL
Enrollment

661

Participants

Timeline

Start Date

December 17, 2015

Primary Completion Date

April 21, 2017

Study Completion Date

March 10, 2022

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Placebo

Tablet; Oral

DRUG

Upadacitinib

Tablet; Oral

Trial Locations (167)

1027

Revita Reumatologiai Rendelo /ID# 140761, Budapest

1100

Rheuma Zentrum Favoriten GmbH /ID# 138787, Vienna

1128

Mautalen Salud e Investigacion /ID# 141419, Buenos Aires

1160

Wilhelminenspital der Stadt Wien /ID# 138788, Vienna

1505

Diag Consult Ctr 17 Sofia EOOD /ID# 141006, Sofia

1612

Diagnostic Consultative Center /ID# 138882, Sofia

1708

HFR Fribourg - Hopital Canton /ID# 139155, Fribourg

2164

LTD M+M Centers /ID# 138818, Ādaži

2217

Optimus Clinical Research Pty. /ID# 138769, Kogarah

2450

Coffs Clinical Trials /ID# 138747, Coffs Harbour

3124

Emeritus Research /ID# 138773, Camberwell

3220

Barwon Rheumatology /ID# 138772, Geelong

5000

Inst. Rheumatologic Strusberg /ID# 145648, Córdoba

6000

Rhumaconsult SPRL /ID# 138813, Charleroi

7010

Porter Rheumatology Ltd /ID# 138347, Nelson

7405

Arthritis Clinical Research Tr /ID# 138945, Cape Town

7600

Winelands Medical Research Ctr /ID# 138944, Stellenbosch

8000

Fejer Megyei Szent Gyorgy Korh /ID# 138554, Székesfehérvár

8310

AZ Sint Lucas /ID# 141338, Bruges

9000

UZ Gent /ID# 138806, Ghent

10000

Klinicka bolnica Sveti Duh /ID# 152812, Zagreb

Medical Center Kuna-Peric /ID# 140365, Zagreb

Poliklinika Bonifarm /ID# 141415, Zagreb

10002

National Taiwan Univ Hosp /ID# 141443, Taipei City

10117

Charité Universitätsmedizin Campus Mitte /ID# 139052, Berlin

10128

Center of Clinical and Basic Research /ID# 141116, Tallinn

10138

East Tallinn Central Hospital /ID# 140618, Tallinn

11217

Taipei Veterans General Hosp /ID# 139234, Taipei

12206

The Center for Rheumatology /ID# 138746, Albany

13125

Immanuel-Krankenhaus /ID# 139059, Berlin

13285

Hopital Saint Joseph /ID# 149188, Marseille

15705

Hosp Nuestra Senora Esperanza /ID# 138997, Santiago de Compostela

16499

Ajou University Hospital /ID# 149311, Suwon

16635

Altoona Ctr Clinical Res /ID# 138741, Duncansville

20902

The Center for Rheumatology & /ID# 139203, Wheaton

22060

Far Eastern Memorial Hospital /ID# 140871, New Taipei City

22332

Inha University Hospital /ID# 149310, Incheon

22763

Asklepios Klinik Altona /ID# 140466, Hamburg

28040

Hospital Clin Univ San Carlos /ID# 138993, Madrid

28144

PMG Research of Salisbury /ID# 141023, Salisbury

28401

PMG Research of Wilmington LLC /ID# 140951, Wilmington

29009

Hospital Regional de Malaga /ID# 138975, Málaga

32810

Omega Research Consultants /ID# 139877, Orlando

33173

Ctr Arthritis & Rheumatic Dise /ID# 141696, Miami

33765

Clinical Res of West FL, Inc. /ID# 138854, Clearwater

34102

Medallion Clinical Research Institute, LLC /ID# 140074, Naples

34652

Suncoast Clinical Research /ID# 138633, New Port Richey

34684

Arthritis Center, Inc. /ID# 141363, Palm Harbor

35015

Chungnam National University Hospital /ID# 138653, Daejeon

37170

CHRU Tours - Hopital Trousseau /ID# 138969, Chambray-lès-Tours

40447

China Medical University Hosp /ID# 139232, Taichung

40515

Bluegrass Community Research /ID# 138295, Lexington

42003

Four Rivers Clinical Research /ID# 141134, Paducah

43606

Arthritis Assoc of NW Ohio /ID# 140953, Toledo

46202

Indiana Univ School of Med /ID# 140077, Indianapolis

48910

Advanced Rheumatology, PC /ID# 140071, Lansing

Justus J. Fiechtner, MD, PC /ID# 138697, Lansing

50937

Uniklinik Koln /ID# 139084, Cologne

51000

Klinicki bolnicki centar Rijeka /ID# 138649, Rijeka

53130

South Karelia Central Hospital /ID# 139973, Lappeenranta

53132

Aurora Rheumatology and Immunotherapy Center /ID# 139306, Franklin

60061

Deerbrook Medical Associates /ID# 139694, Vernon Hills

60076

Clinical Investigation Special /ID# 139696, Skokie

61469

Chonnam National University Hospital /ID# 138651, Gwangju

65026

Odessa National Medical Univ /ID# 139179, Odesa

68114

Westroads Clinical Research /ID# 138304, Omaha

68516

Physician Res. Collaboration /ID# 138533, Lincoln

70403

National Cheng Kung University Hospital /ID# 140868, Tainan City

71110

"University General Hospital of Heraklion PA.G.N.I /ID# 139115", Heraklion

75007

Trinity Universal Res Assoc /ID# 149271, Carrollton

75231

Metroplex Clinical Research /ID# 138698, Dallas

76549

Arthritis Consultants, P.A. /ID# 141138, Killeen

76710

Arthritis & Osteoporosis Clinic /ID# 138703, Waco

77074

Houston Institute for Clin Res /ID# 138716, Houston

77845

Arth and Osteo Clin Brazo Valley /ID# 147809, College Station

78000

University Clinical Centre of the Republic of Srpska /ID# 138819, Banja Luka

University Clinical Centre of the Republic of Srpska /ID# 140372, Banja Luka

78229

Accurate Clinical Management /ID# 139338, San Antonio

78745

Tekton Research, Inc. /ID# 141428, Austin

79007

"MNCE Lviv City Clinical Hospital #4 /ID# 139873", Lviv

80010

Paernu Hospital /ID# 138961, Pärnu

80230

Denver Arthritis Clinic /ID# 139876, Denver

80708

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 140869, Kaohsiung City

82152

Welcker, Planegg, DE /ID# 140467, Planegg

83404

Institute of Arthritis Res /ID# 138548, Idaho Falls

85032

AZ Arthritis & Rheuma Research /ID# 138598, Phoenix

85202

AZ Arthritis and Rheum Assoc /ID# 148651, Mesa

85381

SunValley Arthritis Center, Lt /ID# 140452, Peoria

88100

Universita di Catanzaro Magna Graecia /ID# 139316, Catanzaro

90045

Pacific Arthritis Ctr Med Grp /ID# 138744, Los Angeles

91436

T. Joseph Raoof, MD, Inc. /ID# 140964, Encino

91701

REUMA-GLOBAL, s.r.o. /ID# 139912, Trnava

91722

Covina Arthritis Clinic /ID# 139881, Covina

91786

Inland Rheum Clin Trials Inc. /ID# 138853, Upland

92037

Allergy and Rheum Med Clin /ID# 146082, La Jolla

92288

Klaipeda University Hospital /ID# 141416, Klaipėda

92780

Robin K. Dore MD, Inc /ID# 138688, Tustin

97000

Centro Peninsular de Investigación Clínica SCP /ID# 148160, Colonia Centro

98021

Western Washington Arthritis C /ID# 138728, Bothell

99204

Arthritis Northwest, PLLC /ID# 138539, Spokane

100337

Spitalul Municipal Ploiesti /ID# 138405, Ploieşti

150000

Yaroslavi State Medical Univer /ID# 139908, Yaroslavl

185019

Republican Clin Hos n.a. Baran /ID# 139273, Petrozavodsk

357500

LLC Novaya Klinika /ID# 139269, Pyatigorsk

394036

Voronezh State Medical Univers /ID# 148431, Voronezh

400006

Spitalul Clinic Judetean de Urgenta /ID# 138407, Cluj-Napoca

420012

Kazan State Medical University /ID# 138413, Kazan'

432018

Ulyanovsk Regional Clin Hosp /ID# 139279, Ulyanovsk

443095

Samara Regional Clinical Hosp /ID# 148642, Samara

550245

Spitalul Clinic Judetean de Ur /ID# 138393, Sibiu

85032-9306

AZ Arthritis and Rheum Researc /ID# 138500, Phoenix

AZ Arthritis and Rheum Researc /ID# 139286, Phoenix

85053-4061

Arizona Research Center, Inc. /ID# 140448, Phoenix

85719-1478

University of Arizona Cancer Center - North Campus /ID# 140451, Tucson

61114-4937

OrthoIllinois /ID# 139695, Rockford

62702-3749

Springfield Clinic /ID# 138602, Springfield

04102

MMP Women's Health /ID# 141542, Portland

02048

Mansfield Health Center /ID# 141357, Mansfield

45242-4468

Cincinnati Rheumatic Disease Study Group, Inc. /ID# 138868, Cincinnati

73103-2400

Health Research Oklahoma /ID# 138535, Oklahoma City

29486-7887

Articularis Healthcare Group, Inc d/b/a Low Country Rheumatology /ID# 138689, Summerville

37075-6213

Comprehensive Arthritis Care, a division of Comprehensive Rheumatology Care PLLC /ID# 141021, Hendersonville

77030-3411

Baylor College of Medicine /ID# 138682, Houston

75024-5283

Trinity Universal Research Association /ID# 148649, Plano

R3A IM3

Manitoba Clinic /ID# 139086, Winnipeg

A1B 3V6

Eastern Health /ID# 140431, St. John's

G1V 3M7

Groupe de Recherche en Maladies Osseuses /ID# 138906, Sainte-Foy

S7K 3H3

Dr. Latha Naik /ID# 139089, Saskatoon

748 01

L.K.N. Arthrocentrum, s.r.o /ID# 141340, Hlučín

638 00

Revmatologie, s.r.o. /ID# 138899, Brno

722 00

Artroscan s.r.o. /ID# 138833, Ostrava

274 01

Nemocnice Slany /ID# 141112, Slaný

760 01

PV-MEDICAL s.r.o. /ID# 138913, Zlín

00290

Helsinki Univ Central Hospital /ID# 140381, Helsinki

05800

Kiljava Medical Research /ID# 139260, Hyvinkää

Unknown

Prince of Wales Hospital /ID# 139314, Shatin

D04 T6F4

St Vincent's University Hosp /ID# 138562, Dublin

010009

JSC Nat Scientific Med Res Ctr /ID# 140575, Astana

LT-08661

Vilnius University Hospital /ID# 141348, Vilnius

06090

Unidad de Investigacion de las Enfermedades Reumatologicas SA de CV /ID# 138841, Mexico City

87-100

NZOZ Nasz Lekarz /ID# 138374, Torun

05-825

McBk Sc /Id# 138360, Grodzisk Mazowiecki

15-351

Osteo-Medic spolka cywilna /ID# 138371, Bialystok

82-300

NZOZ Centrum Reumatologiczne /ID# 138353, Elblag

02-118

Rheuma Medicus /ID# 138372, Warsaw

1050-034

Instituto Portugues De Reumatologia /ID# 148315, Lisbon

1349-019

Centro Hospitalar Lisboa Ocidental, EPE /ID# 140594, Lisbon

00935

School of Medicine University of Puerto Rico-Medical Sciences Campus /ID# 139328, San Juan

040 11

ARTROMAC n.o. /ID# 138428, Košice

040 15

Nemocnica Kosice Saca, a.s. /ID# 138918, Košice

921 01

Slovak research center Team Member, Thermium s.r.o. /ID# 139924, Pieštany

921 12

Narodny ustav reumatickych chorob Piestany /ID# 138427, Pieštany

NL 4001

St. Augustine's Medical Centre /ID# 141352, Berea

04763

Hanyang University Seoul Hospi /ID# 138655, Seoul

06591

Cath Univ Seoul St Mary's Hosp /ID# 138652, Seoul

705-718

Daegu Catholic University Med /ID# 139249, Daegu

03080

Seoul National University Hospital /ID# 138659, Seoul

05505

Asan Medical Center /ID# 140579, Seoul

03202

Hospital General Univ de Elche /ID# 138991, Elche

06100

Ankara Numune Training and Res /ID# 139237, Ankara

04070

LLC Revmocentr /ID# 139872, Kyiv

LE1 5WW

Leicester Royal Infirmary /ID# 139184, Leicester

E11 1NR

Whipps Cross Univ Hospital /ID# 139523, London

NW3 2QG

The Royal Free Hospital /ID# 139191, London

EH4 2XU

Western General Hospital /ID# 139524, Edinburgh

SO16 6YD

Southampton General Hospital /ID# 139169, Southampton

WA5 1LZ

Warrington + Halton Hosp NHS /ID# 139195, Warrington

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