Posterior Fossa Decompression With or Without Duraplasty for Chiari Type I Malformation With Syringomyelia

NACompletedINTERVENTIONAL
Enrollment

162

Participants

Timeline

Start Date

April 30, 2016

Primary Completion Date

July 31, 2020

Study Completion Date

July 31, 2020

Conditions
Arnold-Chiari Malformation, Type 1Chiari Malformation Type IType I Arnold-Chiari MalformationSyringomyelia
Interventions
PROCEDURE

Posterior fossa decompression

Planned areas of bone removal from the suboccipital region of the skull and cervical l1 lamina. Then, the constricting epidural band at the level of the foramen magnum is resected.

PROCEDURE

Dural Augmentation

The dura is opened sharply, exposing the cerebellar tonsils, brainstem, and upper spinal cord. After microsurgical dissection, the dura is sewn closed with a dural graft.

Trial Locations (1)

63110

St. Louis Children's Hospital, St Louis

All Listed Sponsors
collaborator

Patient-Centered Outcomes Research Institute

OTHER

collaborator

Johns Hopkins All Children's Hospital

OTHER

collaborator

Arkansas Children's Hospital Research Institute

OTHER

collaborator

Boston Children's Hospital

OTHER

collaborator

Children's Healthcare of Atlanta

OTHER

collaborator

Dartmouth-Hitchcock Medical Center

OTHER

collaborator

Children's Hospital Colorado

OTHER

collaborator

Birmingham Children's Hospital

OTHER

collaborator

Morgan Stanley Children's Hospital

OTHER

collaborator

Phoenix Children's Hospital

OTHER

collaborator

Children's Hospital and Health System Foundation, Wisconsin

OTHER

collaborator

Children's National Research Institute

OTHER

collaborator

Children's Hospital of Philadelphia

OTHER

collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

collaborator

Columbia University

OTHER

collaborator

Gillette Children's Specialty Healthcare

OTHER

collaborator

Levine Children's Hospital

OTHER

collaborator

Children's Hospital Los Angeles

OTHER

collaborator

Ann & Robert H Lurie Children's Hospital of Chicago

OTHER

collaborator

Mayo Clinic

OTHER

collaborator

Nicklaus Children's Hospital f/k/a Miami Children's Hospital

OTHER

collaborator

Medical University of South Carolina Shawn Jenkins Children's Hospital

OTHER

collaborator

Oregon Health and Science University

OTHER

collaborator

Penn State University

OTHER

collaborator

University of Pittsburgh

OTHER

collaborator

Primary Children's Hospital

OTHER

collaborator

Seattle Children's Hospital

OTHER

collaborator

Stanford University

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

The Children's Hospital at OU Medical Center

OTHER

collaborator

Nationwide Children's Hospital

OTHER

collaborator

University of California

OTHER

collaborator

University of Iowa

OTHER

collaborator

University of Michigan

OTHER

collaborator

The University of Texas Health Science Center, Houston

OTHER

collaborator

University of Minnesota

OTHER

collaborator

University of Vermont

OTHER

collaborator

UVA Children's Hospital

OTHER

collaborator

University of Wisconsin, Madison

OTHER

collaborator

Vanderbilt University

OTHER

collaborator

Wake Forest University

OTHER

collaborator

Yale University

OTHER

lead

Washington University School of Medicine

OTHER