Optimal Treatment for Recurrent Clostridium Difficile

PHASE4CompletedINTERVENTIONAL
Enrollment

308

Participants

Timeline

Start Date

December 21, 2015

Primary Completion Date

August 7, 2024

Study Completion Date

August 31, 2024

Conditions
ClostridiumDifficileFidaxomicinVancomycin
Interventions
DRUG

Fidaxomicin

200 mg PO twice daily for 10 days

DRUG

Vancomycin with Taper/Pulse

125 mg PO four times daily for 10 days, followed by 125 mg once daily x 7 days, then once every other day x 7 days, then once every 3rd day x 7 days

DRUG

Vancomycin

125 mg PO for times daily for 10 days

Trial Locations (33)

21202

Rehabilitation R&D Service, Baltimore, MD, Baltimore

33612

James A. Haley Veterans' Hospital, Tampa, FL, Tampa

48105

VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor

60141

Edward Hines Jr. VA Hospital, Hines, IL, Hines

60612

Jesse Brown VA Medical Center, Chicago, IL, Chicago

72205

Central Arkansas Veterans Healthcare System, Little Rock, AR, Little Rock

77030

Michael E. DeBakey VA Medical Center, Houston, TX, Houston

78229

South Texas Health Care System, San Antonio, TX, San Antonio

84148

VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City

85012

Phoenix VA Health Care System, Phoenix, AZ, Phoenix

90073

VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles

90822

VA Long Beach Healthcare System, Long Beach, CA, Long Beach

92161

VA San Diego Healthcare System, San Diego, CA, San Diego

92357

VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda

98108

VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle

85723-0001

Southern Arizona VA Health Care System, Tucson, AZ, Tucson

94304-1290

VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto

95655-4200

VA Northern California Health Care System, Mather, CA, Sacramento

80045-7211

Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora

33744-0000

Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines

32608-1135

North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville

30033-4004

Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur

60141-3030

Edward Hines Jr. VA Hospital, Hines, IL, Hines

02130-4817

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston

48201-1916

John D. Dingell VA Medical Center, Detroit, MI, Detroit

28805-2576

Asheville VA Medical Center, Asheville, NC, Asheville

27705-3875

Durham VA Medical Center, Durham, NC, Durham

44106-1702

Louis Stokes VA Medical Center, Cleveland, OH, Cleveland

73104-5007

Oklahoma City VA Medical Center, Oklahoma City, OK, Oklahoma City

97207-2964

VA Portland Health Care System, Portland, OR, Portland

75216-7167

VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas

53295-0001

Clement J. Zablocki VA Medical Center, Milwaukee, WI, Milwaukee

00921

VA Caribbean Healthcare System, San Juan, PR, San Juan

All Listed Sponsors
lead

VA Office of Research and Development

FED

NCT02667418 - Optimal Treatment for Recurrent Clostridium Difficile | Biotech Hunter | Biotech Hunter