Pembrolizumab With Chemoradiotherapy as Treatment for Muscle Invasive Bladder Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

July 11, 2017

Primary Completion Date

May 12, 2022

Study Completion Date

August 26, 2024

Conditions
Bladder Cancer
Interventions
DRUG

Pembrolizumab

200 mg/m2, IV (in the vein) on day 1 every three weeks (Weeks 1, 3, 7, 10, 13, 16 and 19). until progression or unacceptable toxicity develops.

DRUG

Cisplatin

35 mg/m2, IV (in the vein) every week for six weeks.

RADIATION

Radiotherapy

2.00Gy once daily for 32 fractions, 5 fractions/week over six weeks and two days (a total of 64Gy).

Trial Locations (7)

2013

Prince of Wales Hospital, Randwick

2050

Chris O'Brien Lifehouse, Camperdown

2065

Royal North Shore Hospital, St Leonards

2170

Liverpool Hospital, Liverpool

3002

Peter MacCallum Cancer Centre, Melbourne

3084

Austin Health, Heidelberg

6009

Sir Charles Gairdner Hospital, Nedlands

All Listed Sponsors
collaborator

Peter MacCallum Cancer Centre, Australia

OTHER

lead

Australian and New Zealand Urogenital and Prostate Cancer Trials Group

OTHER

NCT02662062 - Pembrolizumab With Chemoradiotherapy as Treatment for Muscle Invasive Bladder Cancer | Biotech Hunter | Biotech Hunter