A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132)

PHASE3CompletedINTERVENTIONAL
Enrollment

578

Participants

Timeline

Start Date

April 30, 2016

Primary Completion Date

July 18, 2019

Study Completion Date

December 13, 2022

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Atezolizumab

Participants received IV infusion of 1200 mg atezolizumab on Day 1 q3w for 4 or 6 cycles (Cycle length=21 days) in induction dosing period and until disease progression on Day 1 q3w in the maintenance dosing period.

DRUG

Carboplatin

Participants received IV infusion of carboplatin on Day 1 q3w for 4 or 6 cycles (Cycle length=21 days) in induction dosing period with doses calculated using Calvart formula.

DRUG

Cisplatin

Participants received IV infusion of 75 mg/m\^2 cisplatin on Day 1 q3w for 4 or 6 cycles (Cycle length=21 days) in induction dosing period.

DRUG

Pemetrexed

Participants received IV infusion of 500 mg/m\^2 pemetrexed on Day 1 q3w for 4 or 6 cycles (Cycle length=21 days) in induction dosing period and until disease progression on Day 1 q3w in the maintenance dosing period.

Trial Locations (183)

7

Mater Misecordiae University Hospital, Dublin

8

St James's Hospital, Dublin

31

Hospital Nacional Cayetano Heredia, Lima

100

National Taiwan Uni Hospital; Internal Medicine, Taipei

112

Taipei Veterans General Hospital, Taipei

622

Buddhist Dalin Tzuchi General Hospital, Dalin, Chiayi

736

Chi Mei Medical Center Liou Ying Campus, Liuying Township

824

E-DA Hospital; Chest, Kaohsiung City

1303

Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia

2010

St Vincent's Hospital Sydney, Darlinghurst

2045

Tudogyogyintezet Torokbalint, Törökbálint

2076

Sydney Adventist Hospital; Clinical Trial Unit, Sydney

2217

St George Hospital; Medical Oncology, Sydney

3199

Peninsula and South Eastern Haematology and Oncology Group, Frankston

3220

Barwon Health, Geelong

3350

Ballarat Health Services, Ballarat

4020

Redcliffe Hospital, Redcliffe

4040

Clinique André Renard; Pneumologie, Herstal

4101

Mater Adult Hospital, South Brisbane

4600

Klinikum Wels-Grieskirchen GmbH, Wels

7000

Royal Hobart Hospital, Hobart

8000

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz, Székesfehérvár

8208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

8582

Veszprem Megyei Tudogyogyintezet, Farkasgyepű

8800

AZ Delta (Campus Rumbeke), Apotheek, Roeselare

9000

AZ Maria Middelares, Ghent

9024

Petz Aladar Megyei Oktato Korhaz, Győr

9700

Markusovszky Hospital, Szombathely

10043

Azienda Sanitaria Ospedaliera S Luigi Gonzaga; S.C.D.U. di Oncologia Toracica, Orbassano (TO)

10461

Montefiore Medical Center, The Bronx

11490

Tri-Service General Hospital, Taipei

13015

Hopital Nord AP-HM, Marseille

13200

Advanced Medical and Dental Institute; Kompleks Klinikal, Kepala Batas

15009

Centro Oncologico de Galicia COG; Medical Oncology, A Coruña

15212

Allegheny Cancer Center, Pittsburgh

17007

Hospital Universitari de Girona Dr Josep Trueta; Departamento de Oncologia Medica, Girona

17325

Gettysburg Cancer Center, Gettysburg

18009

MICR Oncology Dispensary of Cherkasy Regional Council; Regional Center of Clinical Oncology, Cherkasy

20014

Onkologikoa; Ensayos Clinicos, Donostia / San Sebastian

22031

Virginia Cancer Specialists (Fairfax) - USOR, Fairfax

23601

Peninsula Cancer Institute, Newport News

24014

Blue Ridge Cancer Care, Roanoke

25006

Private Enterprise Private Manufacturing Company Acinus, Kirovograd

27003

Hospital Lucus Augusti; Servicio de Oncologia, Lugo

27513

Swedish Cancer Institute, Cary

28033

MD Anderson Cancer Center, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28050

HM Sanchinarro ? CIOCC, Madrid

29010

Hospital Regional Universitario de Malaga ? Hospital General; Servicio de Neurologia, Málaga

30120

Hospital Universitario Virgen de La Arrixaca; Servicio De Oncologia, El Palmar

30342

Northside Hospital, Atlanta

31008

Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona

Complejo Hospitalario de Navarra; Servicio de Oncologia, Pamplona

32308

Tallahassee Memorial Hospital, Tallahassee

32806

Orlando Health Inc., Orlando

34298

Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque; Service d oncologie, Montpellier

35144

Panevezys Hospital, Panevezys

40022

Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary; Oncothoracic department, Sumy

40536

University of Kentucky; Markey Cancer Center, Lexington

41014

Complejo Hospitalario Nuestra Senora de Valme, Seville

43126

Azienda Ospedaliero Universitaria di Parma, Parma

46009

Instituto Valenciano Oncologia; Oncologia Medica, Valencia

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

46526

Goshen Health System, Goshen

46845

Fort Wayne Med Oncology & Hematology Inc, Fort Wayne

48100

Ospedale Santa Maria Delle Croci, Ravenna

49102

MI Dnipropetrovsk City Multifield Clinical Hospital 4 of Dnipropetrovsk Regional Council, Dnipropetrovsk

50586

Hospital Kuala Lumpur, Kuala Lumpur

54311

St. Vincent Hospital, Green Bay

55100

Ospedale San Luca - USL2 Lucca, Lucca

60426

Ingalls Memorial Hospital, Harvey

60487

HealthCare Research Network II, LLC - PPDS, Tinley Park

61615

Illinois Cancer Care, Peoria

63003

Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne, Clermont-Ferrand

68070

Centre Hospitalier de Mulhouse - Hopital Emile Muller, Mulhouse

68114

Nebraska Methodist Hospital, Omaha

68803

CHI Health St. Francis, Grand Island

69040

MI Zaporizhzhia Regional Clinical Oncological Dispensary Zaporizhzhia SMU Ch of Oncology, Zaporizhzhya

69677

Hopital Louis Pradel; Pneumologie, Bron

71013

Ospedale Casa Sollievo Della Sofferenza IRCCS, San Giovanni Rotondo

73044

Presidio Ospedaliero Vito Fazzi; Unita Operativa Di Oncologia Medica, Lecce

77030

Oncology Consultants PA, Houston

83041

Hopital d Instruction des Armees de Sainte Anne, Toulon

84082

Institut Sainte Catherine, Avignon

87039

Polyclinique de Limoges - Site Chenieux; Oncologie Medicale, Limoges

90017

Los Angeles Hematology Oncology Medical Group, Los Angeles

94010

Centre Hospitalier Intercommunal; Service de Pneumologie, Créteil

94160

Hopital d'Instruction des Armees de Begin, Saint-Mandé

95472

St. Joseph Heritage Healthcare, Sebastopol

97213

Providence Portland Medical Center, Portland

98039

Ospedale San Vincenzo Taormina :Divisione di Oncologia Medica, Taormina

98195

University of Washington, Seattle

100050

Beijing Friendship Hospital Affiliated of Capital University of Medical Science, Beijing

100142

Beijing Cancer Hospital, Beijing

110001

First Hospital of China Medical University, Shenyang

143423

Moscow City Oncology Hospital #62, Moscovskaya Oblast

150040

Regional Clinical Oncology Hospital, Yaroslavl

200000

Shanghai Chest Hospital, Shanghai

200032

Zhongshan Hospital Fudan University, Shanghai

210029

Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing

213003

Changzhou First People's Hospital, Changzhou

230001

Anhui Provincial Hospital; 2F,Tumor chemotherapy Department, Hefei

230088

Anhui Provincial Hospital; Respiratory Department, Hefei

250012

Qilu Hospital, Jinan

300052

Tianjin Medical University General Hospital, Tianjin

310003

The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou

310016

Sir Run Run Shaw Hospital Zhejiang University, Hangzhou

310022

Zhejiang Cancer Hospital, Zhejiang

400058

Medisprof SRL, Cluj-Napoca

410013

Hunan Cancer Hospital, Changsha

430023

Tumor Center,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

454087

Chelyabinsk Regional Clinical Oncology Dispensary, Chelyabinsk

510120

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

700106

Euroclinic Center of Oncology SRL, Iași

900591

Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta, Constanța

2520612

Hospital Clinico Vina del Mar?, Viña del Mar

3000060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

4800827

Sociedad de Investigaciones Medicas Ltda (SIM), Temuco

4941492

Rabin Medical Center, Petach Tiqwa

5822012

Edith Wolfson Medical Center, Holon

7500006

Health & Care SPA, Santiago

7830604

Barzilai Medical Center, Ashkelon

06904

Stamford Hospital; BCC, MOHR, Stamford

48109-0934

University of Michigan, Ann Arbor

00001428

Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich, Buenos Aires

X5002AOQ

Fundacion Clinica Colombo, Córdoba

R8500ACE

Clinica Viedma S.A., Viedma

00144

Istituto Nazionale Tumori Regina Elena, Rome

00161

Azienda Policlinico Umberto I, Rome

460-0001

National Hospital Organization Nagoya Medical Center, Aichi

277-8577

National Cancer Center Hospital East, Chiba

734-8551

Hiroshima University Hospital, Hiroshima

070-8644

National Hospital Organization Asahikawa Medical Center, Hokkaido

670-8520

National Hospital Organization Himeji Medical Center, Hyōgo

920-8641

Kanazawa University Hospital, Ishikawa

890-8520

Kagoshima University Hospital, Kagoshima

241-8515

Kanagawa Cancer Center, Kanagawa

980-8574

Tohoku University Hospital, Miyagi

951-8520

Niigata University Medical & Dental Hospital, Niigata

565-0871

Osaka University Hospital, Osaka

569-8686

Osaka Medical and Pharmaceutical University Hospital, Osaka

849-8501

Saga University Hospital, Saga

770-8503

Tokushima University Hospital, Tokushima

113-8431

Juntendo University Hospital, Tokyo

113-8603

Nippon Medical School Hospital, Tokyo

113-8677

Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Tokyo

135-8550

The Cancer Institute Hospital of JFCR, Tokyo

141-8625

NTT Medical Center Tokyo, Tokyo

755-0241

National Hospital Organization Yamaguchi - Ube Medical Center, Yamaguchi

LV-1079

Riga East Clinical University Hospital Latvian Oncology Centre, Riga

4819 EV

Amphia Ziekenhuis, Breda

6716 RP

Ziekenhuis Gelderse Vallei, Ede

3844 DG

Ziekenhuis St. Jansdal, Harderwijk

6162 BG

Zuyderland Medisch Centrum - Sittard Geleen, Sittard-Geleen

2547 EX

Haga Ziekenhuis, The Hague

5042AD

ETZ TweeSteden, Tilburg

2674-514

Hospital Beatriz Angelo, Loures

4454-509

Unidade Local de Saude de Matosinhos SA, Matosinhos Municipality

4460-188

Hospital CUF Porto; Servico de Imunoalergologia, Senhora Da Hora - Porto

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

03203

Hospital General Universitario de Elche; Servicio de Oncologia, Elche

08916

Hospital Universitario Germans Trias i Pujol, Badalona

08908

ICO L'Hospitalet; Servicio de oncologia medica, L'Hospitalet de Llobregat

08740

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Sant Andreu de la Barca

08304

Hospital de Mataro, Mataro

03010

Hospital General Univ. de Alicante, Alicante

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08028

Hospital Universitari Dexeus - Grupo Quironsalud; Servicio de Oncologia Medica, Barcelona

09006

C.A.U de Burgos- Hospital Universitario de Burgos; Servicio de Oncologia, Burgos

02096

Kyiv Railway Clinical Hospital #3 of Branch Health Center of PJSC Ukrainian Railway; Surgery Dept, Kyiv

BS2 8ED

Bristol Haematology and Oncology centre, Bristol

CF14 2TL

Velindre Hospital, Cardiff

G12 0YN

Gartnavel General Hospital; Beatson West of Scotland Cancer Centre, Glasgow

IV2 3UV

Raigmore Hospital, Inverness

SW17 ORE

St George?s Hospital, London

W6 8RF

Charing Cross Hospital, London

OX3 7LJ

Churchill Hospital, Oxford

PL6 8DH

Derriford Hospital; Plymouth Oncology Centre, Plymouth

RM7 0AG

Queen's Hospital, Romford

TR1 3LQ

Royal Cornwall Hospital, Truro

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02657434 - A Study of Atezolizumab in Combination With Carboplatin or Cisplatin + Pemetrexed Compared With Carboplatin or Cisplatin + Pemetrexed in Participants Who Are Chemotherapy-Naive and Have Stage IV Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (IMpower 132) | Biotech Hunter | Biotech Hunter