600
Participants
Start Date
April 12, 2018
Primary Completion Date
December 31, 2024
Study Completion Date
June 30, 2025
Heparin Sodium
A bottle solution of Heparin Sodium(2ml:12500IU) is added to 50ml saline and administered i.v. continuously for 24 hours, which last 7 days or until the death or discharge. The same amount of 0.9% saline as the heparin group will be administered in the placebo group.
Saline
For all the severe sepsis or septic shock patients, normal saline will be administered for fluid resuscitation according to the Guideline of Survival Sepsis Campaign.
RECRUITING
The fist Affiliated Hospital Harbin Medical University, Haerbin
RECRUITING
Xiangya Third Hospital of Central South University, Changsha
RECRUITING
Zhongda Hospital, Nanjing
RECRUITING
First Affiliated Hospital of Dalian Medical University, Dalian
RECRUITING
Second Affiliated Hospital of Dalian Medical University, Dalian
RECRUITING
second Affiliated Hospital of china Medical University, Shenyang
RECRUITING
Shenyang Fourth People's Hospital, Shenyang
RECRUITING
Qilu Hospital of Shandong University（qingdao）, Qingdao
RECRUITING
West China Hospital of Sichuan University, Chengdu
RECRUITING
First Affiliated Hospital of Kunming Medical University, Kunming
RECRUITING
the Second Affiliated Hospital of Kunming University, Kunming
RECRUITING
Beijing Friendship Hospital ， Capital Medical University, Beijing
RECRUITING
Changgeng Hospital of Tsinghua University, Beijing
RECRUITING
People's Hospital of Peking University, Beijing
RECRUITING
First Affiliated Hospital of Jilin Medical University, Jilin
RECRUITING
Qinhuangdao First Hospital, Qinhuangdao
RECRUITING
Liaoning Provincial People's Hospital, Shenyang
West China Hospital
OTHER
Zhongda Hospital
OTHER
The First Affiliated Hospital of Dalian Medical University
OTHER
Shengjing Hospital
OTHER
The First Hospital of Jilin University
OTHER
Qilu Hospital of Shandong University
OTHER
The Second Affiliated Hospital of Kunming Medical University
OTHER
The First Hospital of Qinhuangdao
OTHER_GOV
The Second Affiliated Hospital of Dalian Medical University
OTHER
First Affiliated Hospital of Harbin Medical University
OTHER
Peking University People's Hospital
OTHER
The People's Hospital of Liaoning Province
OTHER
Fourth People's Hospital of Shenyang
OTHER
Beijing Tsinghua Changgeng Hospital
OTHER
First Affiliated Hospital of Kunming Medical University
OTHER
The Affiliated Hospital of Qingdao University
OTHER
Beijing Friendship Hospital
OTHER
General Hospital of Ningxia Medical University
OTHER
The First Affiliated Hospital of Nanchang University
OTHER
China Medical University, China
OTHER