86
Participants
Start Date
March 4, 2016
Primary Completion Date
August 14, 2018
Study Completion Date
February 7, 2024
Doravirine, Tenofovir, Lamivudine - Blinded
A single tablet FDC containing doravirine 100 mg, lamivudine (3TC) 300 mg and tenofovir disoproxil fumarate (TDF) 300 mg administered orally, once daily for 12 weeks during the Blinded period
Doravirine, Tenofovir, Lamivudine - Open-Label
A single-tablet FDC containing doravirine 100 mg, 3TC 300 mg and TDF 300 mg administered orally, once daily for either 12 or 24 weeks during the Open-Label Period; also an additional 96 weeks during the Open-Label extension period 1; a maximum total duration of treatment of 228 weeks during the Open-Label extension period 2; and a maximum total duration of treatment of 324 weeks during the Open-Label extension period 3.
ATRIPLA^TM
A single tablet FDC containing efavirenz (EFV) 600 mg, emtricitabine (FTC) 200 mg, and TDF 300 mg administered orally, once daily for 12 weeks during the Blinded period
Placebo to ATRIPLA™
A single placebo to ATRIPLA™ tablet administered orally, once daily for 12 weeks during the Blinded period
Placebo to Doravirine, Tenofovir, Lamivudine
A single placebo to doravirine, tenofovir, lamivudine tablet administered orally, once daily for 12 weeks during the Blinded period
Merck Sharp & Dohme LLC
INDUSTRY