Study of the Safety, Tolerability and Efficacy of KPT-8602 in Participants With Relapsed/Refractory Cancer Indications

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

277

Participants

Timeline

Start Date

January 31, 2016

Primary Completion Date

August 31, 2024

Study Completion Date

December 23, 2024

Conditions
Relapsed/Refractory Multiple Myeloma (RRMM)Metastatic Colorectal Cancer (mCRC)Metastatic Castration-Resistant Prostate Cancer (mCRPC)Higher-Risk Myelodysplastic Syndrome (HR-MDS)Acute Myeloid Leukemia (AML)Newly Diagnosed Intermediate/High-Risk MDS
Interventions
DRUG

KPT-8602

Participants will receive KPT-8602 oral tablets.

DRUG

ASTX727

ASTX727 is a combination drug of 35 mg decitabine and 100 mg cedazuridine.

DRUG

Dexamethasone

Participants will receive dexamethasone oral tablets.

Trial Locations (46)

10021

Weill Cornell Medical College, New York

19104

University of Pennsylvania Abramson Cancer Center Clinical Research Unit, Philadelphia

22031

(USO) Virginia Cancer Specialists, Fairfax

22903

University of Virginia, Charlottesville

28027

Clinical Universidad de Navarra (Madrid site), Madrid

31008

Hospital Clínic of Barcelona, Pamplona

33604

CHU de Bordeaux, Pessac

33612

Moffitt Cancer Center, Tampa

37044

CHU de Tours, Tours

37232

Vanderbilt University Medical Center, Nashville

38120

Baptist Cancer Center, Memphis

43210

Ohio State University, The James Cancer Hospital and Solove Research Institute, Columbus

44000

CHU Nantes, Nantes

45236

(USO) Oncology Hematology Care, Cincinnati

49503

Cancer and Hematology Centers of Western Michigan, Grand Rapids

54500

CHRU de Nancy, Vandœuvre-lès-Nancy

64132

Sarah Cannon Cancer Center (HCA Midwest KC), Kansas City

69101

Callahan Cancer Center, North Platte

75014

Hôpital Cochin APHP, Paris

75015

Hôpital Necker, Paris

75246

(USO) Texas Oncology (Dallas), Dallas

75702

(USO) Texas Oncology (Tyler), Tyler

77030

MD Anderson Cancer Center, Houston

78705

(USO) Texas Oncology Austin - Midtown, Austin

80045

Rocky Mountain Regional VA Medical Center, Aurora

80218

Sarah Cannon Cancer Center - (Colorado Blood Cancer Institute), Denver

84112

Huntsman Cancer Institute, Salt Lake City

87131

University of New Mexico, Albuquerque

90095

David Geffen School of Medicine at UCLA, Los Angeles

91105

Oncology Institute of Hope and Innovation, Pasadena

98109

University of Washington, Seattle

98684

(USO) Compass oncology, Vancouver

300041

Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences, Tianjin

430022

China, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

80120-4413

(USO) Rocky Mountain Cancer Centers, Littleton

07601

John Theurer Cancer Center at Hackensack UMC, Hackensack

Unknown

McMaster - Juravinski Cancer Centre, Hamilton

Princess Margaret Cancer Research, Toronto

MUHC GLEN Site Cedars - Cancer Centre, Montreal

Hôpital St Louis, Paris

Hospital San Pedro de Alcántara, Cáceres

Hospital 12 de Octubre, Madrid

Hospital Universitario Central Asturias, Oviedo

Hospital La Fe, Valencia

M5G 2M9

Princess Margaret Cancer Center, Toronto

08036

Clínica Universidad de Navarra, Barcelona

Sponsors
All Listed Sponsors
lead

Karyopharm Therapeutics Inc

INDUSTRY