To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites

PHASE3CompletedINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

July 1, 2015

Primary Completion Date

December 30, 2016

Study Completion Date

December 30, 2016

Conditions
Ascites
Interventions
DRUG

Propranolol

Propranolol will be started at a dose of 40 mg and will be titrated based on pulse rate with target of 55-60 beats per minute or 20-25% reduction in heart rate and maximum tolerated dose.If any patients develop intolerable side effects, they will be withdrawn from the study

PROCEDURE

Endoscopic variceal ligation (EVL)

Patients in EVL group will undergo regular sessions of UGIE with EVL till variceal eradication every 2- 4 weekly followed by 3 monthly for initial 6 months and 6 monthly in rest of the study period. If any patient develop acute variceal hemorrhage on follow up , will be treated inpatient with standard medical therapy(SMT) .

Trial Locations (1)

Unknown

Department of Hepatology,Postgraduate Institute of Medical Education and Research, Chandigarh

All Listed Sponsors
lead

Post Graduate Institute of Medical Education and Research, Chandigarh

OTHER

NCT02649335 - To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites | Biotech Hunter | Biotech Hunter