SPI-2012 vs Pegfilgrastim in the Management of Neutropenia in Participants With Breast Cancer With Docetaxel and Cyclophosphamide (ADVANCE)

PHASE3CompletedINTERVENTIONAL
Enrollment

406

Participants

Timeline

Start Date

January 19, 2016

Primary Completion Date

January 24, 2018

Study Completion Date

October 31, 2018

Conditions
NeutropeniaBreast Cancer
Interventions
DRUG

SPI-2012

Single-use syringes for subcutaneous injection, administered on Day 2 of each cycle

DRUG

Pegfilgrastim

Single-dose subcutaneous injection administered on Day 2 of each cycle

DRUG

Docetaxel

Standard therapy

DRUG

Cyclophosphamide

Standard therapy

Trial Locations (81)

11733

North Shore Hematology Oncology Associates, East Setauket

13496

Cha Bundang Medical Center, Seongnam-si

15232

University of Pittsburgh Medical Center (UPMC), Pittsburgh

19013

Associates in Hematology and Oncology, PC, Upland

20817

RCCA MD LLC/The Center for Cancer and Blood Disorders, Bethesda

23704

Delta Oncology Associates, Portsmouth

26506

West Virginia University, Morgantown

27518

Waverly Hematology Oncology, Cary

29607

Bon Secours Saint Francis Cancer, Greenville

29621

AnMed Health Cancer Center, Anderson

29732

Carolina Blood and Cancer Care, Rock Hill

30905

Dwight D. Eisenhower Army Medical Center, Fort Gordon

31404

Memorial Health University Medical Center, Savannah

31904

John B Amos Cancer Center, Columbus

32713

Omega Research Consultants LLC, DeBary

32763

Mid Florida Hematology and Oncology Centers, Orange City

33014

Lakes Research, LLC, Miami Lakes

33133

AMPM Research Clinic, Miami

33324

Florida Cancer Research Institute, Plantation

33881

Bond Clinic, P.A., Winter Haven

34691

Pasco Pinellas Cancer Center, Holiday

38138

The West Clinic, PC, d/b/a West Cancer Center, Germantown

38501

Cookeville Regional Medical Center, Cookeville

39401

Forrest General Hospital, Hattiesburg

41101

Ashland-Bellefonte Cancer Center, Ashland

42003

West Ky Hematology & Oncology Group, PSC, Paducah

44710

Aultman Hospital, Canton

44718

Gabrail Cancer Center Research, Canton

45219

The Lindner Research Center at the Christ Hospital, Cincinnati

46237

Franciscan St. Francis Health, Indianapolis

46391

Northern Indiana Cancer Research Consortium, Westville

47150

Floyd Memorial Cancer Center of Indiana, New Albany

48073

Quest Research Institute, Royal Oak

59102

St. Vincent Frontier Cancer Center, Billings

60068

Oncology Specialists, SC, Park Ridge

60435

Joliet Oncology Hematology Associates, Joliet

60625

Clintell, Inc/Swedish Covenant Hospital, Chicago

61114

Swedish American Cancer Center, Rockford

61801

Carle Cancer Center, Urbana

64804

Freeman Health Systems, Joplin

68510

Southeast Nebraska Hematology & Oncology Consultants, PC, Lincoln

68803

Saint Francis Cancer Treatment Center, Grand Island

70433

Pontchartrain Cancer Center, Covington

71105

Highland Clinic, Shreveport

71913

Genesis Cancer Center, Hot Springs

75082

Methodist Richardson Medical Center- Cancer Center, Richardson

75203

Texas Oncology -Methodist Dallas Cancer Center, Dallas

77030

Oncology Consultants, Houston

77802

CHI St. Joseph Health Cancer Center, Bryan

78503

Texas Oncology, PA, McAllen

83706

Saint Alphonsus Regional Medical Center, Boise

84403

Northern Utah Associates, Ogden

85306

Arizona Center for Cancer Care, Glendale

85364

Yuma Regional Medical Center, Yuma

85715

Arizona Clinical Research Center/ ACRC, Tucson

90603

Oncology Institute of Hope and Innovation, Whittier

90806

Long Beach Memorial Medical Center, Long Beach

90813

Pacific Shores Medical Group, Long Beach

91307

Wellness Oncology Hematology, West Hills

91910

Precision Research Institute, LLC, Chula Vista

92373

Emad Ibrahim, MD, Inc., Redlands

92501

Compassionate Cancer Care Medical Group, Inc, Riverside

92708

Compassionate Care Research Group, Inc., Fountain Valley

92801

Pacific Cancer Medical Center, Inc., Anaheim

92879

Compassionate Cancer Care Medical Group, Inc., Corona

93030

Ventura County Hematology-Oncology Specialists, Oxnard

93309

CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center, Bakersfield

94588

Valley Medical Oncology Consultants, Pleasanton

94704

Alta Bates Summit Medical Center, Berkeley

95403

St Joseph Heritage Healthcare Institution, Santa Rosa

97330

Good Samaritan Hospital Corvallis, Corvallis

98405

Northwest Medical Specialties, PLLC, Tacoma

Arkansas

"NEA Baptist Clinic , Fowler Family Center for Cancer Care"

04856

Penobscot Bay Medical Center, Rockport

01608v

Reliant Medical Group, Worcester

08724

New Jersey Hematology Oncology Associates, Brick

44504 44501

Mercy Health Youngstown LLC DBA, Youngstown

J4V 2H1

CISSS de la Montérégie-Centre, Greenfield Park

H3T 1E2

Jewish General Hospital, Montreal

G1S 4L8

CHU de Quebec - Universite Laval, Québec

03722

Severance Hospital, Sinchon-dong

All Listed Sponsors
lead

Spectrum Pharmaceuticals, Inc

INDUSTRY

NCT02643420 - SPI-2012 vs Pegfilgrastim in the Management of Neutropenia in Participants With Breast Cancer With Docetaxel and Cyclophosphamide (ADVANCE) | Biotech Hunter | Biotech Hunter