A Study of BBI608 Administrated With FOLFIRI + Bevacizumab in Adult Patients With Metastatic Colorectal Cancer

240 mg twice daily (480 mg total daily dose)

400 mg/m2 bolus will be administered intravenously immediately following irinotecan/levofolinate infusion, followed by 1200 mg/m2/day (total 2400 mg/m2) continuous infusion per cycle(14 days).

180 mg/m2 together with levofolinate will be administered intravenously per cycle(14 days).

200 mg/m2 together with Irinotecan will be administered intravenously per cycle(14 days).

5 mg/kg will be administered intravenously following irinotecan/levofolinate infusion per cycle(14 days).