Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

February 10, 2016

Primary Completion Date

November 11, 2024

Study Completion Date

November 11, 2024

Conditions
Neoplasms
Interventions
DRUG

VIP152 (BAY 1251152)

The starting dose of Cohort 1 will be 5 mg IV (30 minute infusion) fixed dose once weekly (5 mg/week) for 21 day cycles.

DRUG

VIP152 (BAY 1251152) 30 mg

30 mg IV (30 minute infusion) fixed dose once weekly of a 21 day cycle.

DRUG

Keytruda

200 mg IV fixed dose once every 3 weeks of a 21 day cycle

DRUG

VIP152 (BAY 1251152) 15 mg

The starting dose of Cohort 3 will be 15 mg IV (30 minute infusion) fixed dose once weekly (15 mg/week) for 21 day cycles.

Trial Locations (16)

10065

Memorial Sloan Kettering Cancer Center, New York

20904

Maryland Oncology Hematology, Silver Spring

28040

START Madrid- Fundación Jiménez Diaz, Madrid

37203

Sarah Cannon Research Institute, Nashville

40202

Norton Cancer Institute, Louisville

45219

University of Cincinnati Medical Center, Cincinnati

57105

Avera Health, Sioux Falls

72762

Highlands Oncology Group, Springdale

77030

University of Texas MD Anderson Cancer Center, Houston

78229

NEXT Oncology, San Antonio

78758

NEXT Oncology, Austin

97239

Oregon Health and Science University, Portland

97401

Willamette Valley Cancer Institute, Eugene

2520598

Oncocentro, Viña del Mar

2540364

Centro de Investigaciones Clínicas Viña del Mar, Viña del Mar

07601

John Theurer Cancer Center, Hackensack

All Listed Sponsors
lead

Vincerx Pharma, Inc.

INDUSTRY

NCT02635672 - Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer | Biotech Hunter | Biotech Hunter