Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

418

Participants

Timeline

Start Date

December 22, 2015

Primary Completion Date

May 18, 2023

Study Completion Date

April 30, 2027

Conditions
Extensive Stage Small Cell Lung CarcinomaLimited Stage Small Cell Lung Carcinoma
Interventions
RADIATION

Three-Dimensional Conformal Radiation Therapy

daily fractions

RADIATION

Intensity-Modulated Radiation Therapy

daily fractions

Trial Locations (285)

10021

Lenox Hill Hospital, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10305

Staten Island University Hospital, Staten Island

10461

Montefiore Medical Center-Einstein Campus, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

10604

Memorial Sloan Kettering Westchester, Harrison

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11553

Memorial Sloan Kettering Nassau, Uniondale

11706

Northwell Health Imbert Cancer Center, Bay Shore

11725

Memorial Sloan Kettering Commack, Commack

13210

State University of New York Upstate Medical University, Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

14905

Arnot Ogden Medical Center/Falck Cancer Center, Elmira

17325

Adams Cancer Center, Gettysburg

17403

WellSpan Health-York Cancer Center, York

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

18512

Northeast Radiation Oncology Center, Dunmore

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19001

Jefferson Abington Hospital, Abington

19008

Crozer-Keystone Regional Cancer Center at Broomall, Broomall

19010

Bryn Mawr Hospital, Bryn Mawr

19063

Riddle Memorial Hospital, Media

19096

Lankenau Medical Center, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19114

Jefferson Torresdale Hospital, Philadelphia

19140

Temple University Hospital, Philadelphia

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19342

Crozer Regional Cancer Center at Brinton Lake, Glen Mills

19605

Penn State Health Saint Joseph Medical Center, Reading

19611

Reading Hospital, West Reading

19713

Helen F Graham Cancer Center, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

21014

UM Upper Chesapeake Medical Center, Bel Air

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

University of Maryland Medical Center, Baltimore

University of Maryland/Greenebaum Cancer Center, Baltimore

21204

UM Saint Joseph Medical Center, Towson

21237

MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore

21239

MedStar Good Samaritan Hospital, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

21401

Anne Arundel Medical Center, Annapolis

21801

TidalHealth Peninsula Regional, Salisbury

21811

TidalHealth Richard A Henson Cancer Institute, Ocean Pines

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

26506

West Virginia University Healthcare, Morgantown

28025

Atrium Health Cabarrus/LCI-Concord, Concord

28112

Atrium Health Union/LCI-Union, Monroe

28150

Atrium Health Cleveland/LCI-Cleveland, Shelby

28203

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28210

Atrium Health Pineville/LCI-Pineville, Charlotte

28262

Atrium Health University City/LCI-University, Charlotte

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29621

AnMed Health Cancer Center, Anderson

29646

Self Regional Healthcare, Greenwood

29720

Lancaster Radiation Therapy Center, Lancaster

29730

Rock Hill Radiation Therapy Center, Rock Hill

29926

The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island

30041

Northside Hospital-Forsyth, Cumming

30303

Grady Health System, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30309

Piedmont Hospital, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Northside Hospital, Atlanta

31404

Memorial Health University Medical Center, Savannah

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

32806

Orlando Health Cancer Institute, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

Miami Cancer Institute, Miami

33316

Broward Health Medical Center, Fort Lauderdale

33486

Boca Raton Regional Hospital, Boca Raton

33612

Moffitt Cancer Center, Tampa

35233

University of Alabama at Birmingham Cancer Center, Birmingham

35401

Lewis and Faye Manderson Cancer Center, Tuscaloosa

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37804

Blount Memorial Hospital, Maryville

37916

Thompson Cancer Survival Center, Knoxville

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

43222

Mount Carmel Health Center West, Columbus

44024

Geauga Hospital, Chardon

44035

Mercy Cancer Center-Elyria, Elyria

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44304

Summa Health System - Akron Campus, Akron

44307

Cleveland Clinic Akron General, Akron

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

45415

Dayton Physician LLC-Miami Valley Hospital North, Dayton

45601

Adena Regional Medical Center, Chillicothe

46016

Ascension Saint Vincent Anderson, Anderson

46526

Goshen Center for Cancer Care, Goshen

46805

Parkview Hospital Randallia, Fort Wayne

46845

Parkview Regional Medical Center, Fort Wayne

47303

IU Health Ball Memorial Hospital, Muncie

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48043

McLaren Cancer Institute-Macomb, Mount Clemens

48044

Michigan Healthcare Professionals Macomb, Macomb

48060

McLaren-Port Huron, Port Huron

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48085

William Beaumont Hospital - Troy, Troy

48098

GenesisCare USA - Troy, Troy

48106

Saint Joseph Mercy Hospital, Ann Arbor

48114

Saint Joseph Mercy Brighton, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

48124

Beaumont Hospital - Dearborn, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Michigan Healthcare Professionals Farmington, Farmington Hills

48341

Saint Joseph Mercy Oakland, Pontiac

48346

McLaren Cancer Institute-Clarkston, Clarkston

Michigan Healthcare Professionals Clarkston, Clarkston

48446

McLaren Cancer Institute-Lapeer Region, Lapeer

48503

Genesys Hurley Cancer Institute, Flint

48532

McLaren Cancer Institute-Flint, Flint

48706

McLaren Cancer Institute-Bay City, Bay City

48858

McLaren Cancer Institute-Central Michigan, Mount Pleasant

48867

McLaren Cancer Institute-Owosso, Owosso

49007

West Michigan Cancer Center, Kalamazoo

49085

Lakeland Medical Center Saint Joseph, Saint Joseph

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Spectrum Health at Butterworth Campus, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49770

McLaren Cancer Institute-Northern Michigan, Petoskey

50309

Iowa Methodist Medical Center, Des Moines

52402

Saint Luke's Hospital, Cedar Rapids

52403

Mercy Hospital, Cedar Rapids

53024

Aurora Cancer Care-Grafton, Grafton

53038

UW Cancer Center Johnson Creek, Johnson Creek

53045

Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

Aurora Medical Center in Summit, Summit

53132

Ascension Saint Francis - Reiman Cancer Center, Franklin

53142

Aurora Cancer Care-Kenosha South, Kenosha

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53405

Ascension All Saints Hospital, Racine

53792

University of Wisconsin Carbone Cancer Center, Madison

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54476

Diagnostic and Treatment Center, Weston

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54601

Gundersen Lutheran Medical Center, La Crosse

Mayo Clinic Health System-Franciscan Healthcare, La Crosse

54701

Mayo Clinic Health System-Eau Claire Clinic, Eau Claire

54703

Mayo Clinic Health System Eau Claire Hospital-Luther Campus, Eau Claire

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55057

Mayo Clinic Radiation Therapy-Northfield, Northfield

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55805

Saint Luke's Hospital of Duluth, Duluth

55905

Mayo Clinic in Rochester, Rochester

56001

Mayo Clinic Health Systems-Mankato, Mankato

56007

Mayo Clinic Health System in Albert Lea, Albert Lea

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

59804

Community Medical Hospital, Missoula

60048

Condell Memorial Hospital, Libertyville

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60141

Edward Hines Jr VA Hospital, Hines

60153

Loyola University Medical Center, Maywood

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

Rush University Medical Center, Chicago

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61801

Carle Cancer Center, Urbana

62401

Crossroads Cancer Center, Effingham

62526

Decatur Memorial Hospital, Decatur

62781

Memorial Medical Center, Springfield

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

64111

Saint Luke's Hospital of Kansas City, Kansas City

64116

North Kansas City Hospital, Kansas City

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

64804

Freeman Health System, Joplin

66044

Lawrence Memorial Hospital, Lawrence

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

67214

Ascension Via Christi Hospitals Wichita, Wichita

Wesley Medical Center, Wichita

68198

University of Nebraska Medical Center, Omaha

70112

Tulane University School of Medicine, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

77573

UTMB Cancer Center at Victory Lakes, League City

80113

Swedish Medical Center, Englewood

80524

Poudre Valley Hospital, Fort Collins

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84405

Ogden Regional Medical Center, Ogden

85719

Banner University Medical Center - Tucson, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

89502

Renown Regional Medical Center, Reno

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

92868

Saint Joseph Hospital - Orange, Orange

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94611

Kaiser Permanente Oakland-Broadway, Oakland

94904

Marin General Hospital, Greenbrae

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95340

Mercy UC Davis Cancer Center, Merced

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

96161

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

96701

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96813

Queen's Medical Center, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

97030

Legacy Mount Hood Medical Center, Gresham

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

06606

Hartford HealthCare - Saint Vincent's Medical Center, Bridgeport

06520

Yale University, New Haven

01805

Lahey Hospital and Medical Center, Burlington

01854

Lowell General Hospital, Lowell

01655

UMass Memorial Medical Center - University Campus, Worcester

03820

Wentworth-Douglass Hospital, Dover

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07631

Englewood Hospital and Medical Center, Englewood

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08060

Virtua Memorial, Mount Holly

08043

Virtua Voorhees, Voorhees Township

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77555-0565

University of Texas Medical Branch, Galveston

05602

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

University of Vermont Medical Center, Burlington

05819

Norris Cotton Cancer Center-North, Saint Johnsbury

K7L 2V7

Kingston Health Sciences Centre, Kingston

N6A 4L6

London Regional Cancer Program, London

L3Y 2P9

Stronach Regional Health Centre at Southlake, Newmarket

K1H 8L6

Ottawa Hospital and Cancer Center-General Campus, Ottawa

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

H2W 1S6

McGill University Department of Oncology, Montreal

H2X 3E4

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3H 2R9

The Research Institute of the McGill University Health Centre (MUHC), Montreal

G1R 2J6

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

J1H 5N4

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Radiation Therapy Oncology Group

NETWORK

lead

NRG Oncology

OTHER