A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty

NATerminatedINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

June 30, 2016

Primary Completion Date

November 30, 2018

Study Completion Date

November 30, 2018

Conditions
Urethral Stricture
Interventions
PROCEDURE

Ventral buccal mucosa onlay urethroplasty

Ventral buccal graft onlay involves a midline perineal incision and retraction of the bulbospongiosum muscle downward to expose the ventral urethral surface. The corpus spongiosum is incised longitudinally to expose the urethral lumen and the incision is extended proximal and distal to the established stricture. The buccal mucosa graft is harvested and trimmed to the length and width of the urethrotomy and the graft is sutured at the proximal and distal apices and a running suture at the lateral margins to establish a tight anastomosis. Ventral placement allows for limited urethral mobilization and easy access, but there is concern about higher likelihood of diverticulum formation and development of other associated complications - such as post void dribbling and ejaculatory dysfunction.

PROCEDURE

Dorsal buccal mucosa onlay urethroplasty

Dorsal buccal onlay also involves a midline perineal incision. The bulbo-cavernosum and corpora cavernosum are dissected from the bulbar urethra allowing for complete mobilization of the urethra. The urethra is rotated 180 degrees to allow for dorsal access and an incision is made on the dorsal urethra proximal and distal to the stricture location. The buccal graft is harvested and trimmed to the appropriate size of the urethrotomy and spread on the overlying tunica albuginea of the corporal bodies. The urethra is rotated back to allow for suturing of the left mucosal margin to the left margin of the buccal graft and corporal bodies, essentially covering the entire urethral plate. Dorsal placement has potential for a more stable vascular bed for graft sustainability and less spongiosal bleeding, but requires a greater urethral mobilization and longer operative times.

Trial Locations (1)

94143

University of California San Francisco, San Francisco

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Minnesota

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

University of Iowa

OTHER

collaborator

University of Kansas

OTHER

collaborator

Central Ohio Urology Group

OTHER

collaborator

Loyola University Chicago

OTHER

collaborator

Lahey Clinic

OTHER

collaborator

University of Washington

OTHER

collaborator

New York University

OTHER

collaborator

University of California, San Diego

OTHER

collaborator

University of Utah

OTHER

lead

University of California, San Francisco

OTHER

NCT02634619 - A Study of Dorsal Versus Ventral Buccal Mucosa Graft Onlay for Bulbar Urethroplasty | Biotech Hunter | Biotech Hunter