95
Participants
Start Date
June 30, 2016
Primary Completion Date
November 30, 2018
Study Completion Date
November 30, 2018
Ventral buccal mucosa onlay urethroplasty
Ventral buccal graft onlay involves a midline perineal incision and retraction of the bulbospongiosum muscle downward to expose the ventral urethral surface. The corpus spongiosum is incised longitudinally to expose the urethral lumen and the incision is extended proximal and distal to the established stricture. The buccal mucosa graft is harvested and trimmed to the length and width of the urethrotomy and the graft is sutured at the proximal and distal apices and a running suture at the lateral margins to establish a tight anastomosis. Ventral placement allows for limited urethral mobilization and easy access, but there is concern about higher likelihood of diverticulum formation and development of other associated complications - such as post void dribbling and ejaculatory dysfunction.
Dorsal buccal mucosa onlay urethroplasty
Dorsal buccal onlay also involves a midline perineal incision. The bulbo-cavernosum and corpora cavernosum are dissected from the bulbar urethra allowing for complete mobilization of the urethra. The urethra is rotated 180 degrees to allow for dorsal access and an incision is made on the dorsal urethra proximal and distal to the stricture location. The buccal graft is harvested and trimmed to the appropriate size of the urethrotomy and spread on the overlying tunica albuginea of the corporal bodies. The urethra is rotated back to allow for suturing of the left mucosal margin to the left margin of the buccal graft and corporal bodies, essentially covering the entire urethral plate. Dorsal placement has potential for a more stable vascular bed for graft sustainability and less spongiosal bleeding, but requires a greater urethral mobilization and longer operative times.
University of California San Francisco, San Francisco
Collaborators (1)
University of Minnesota
OTHER
Baylor College of Medicine
OTHER
University of Iowa
OTHER
University of Kansas
OTHER
Central Ohio Urology Group
OTHER
Loyola University Chicago
OTHER
Lahey Clinic
OTHER
University of Washington
OTHER
New York University
OTHER
University of California, San Diego
OTHER
University of Utah
OTHER
University of California, San Francisco
OTHER