52
Participants
Start Date
December 31, 2015
Primary Completion Date
December 31, 2020
Study Completion Date
December 31, 2020
Mannitol
Mannitol consists of inhaling 0 (empty capsule acting as a placebo), 5, 10, 20, 40, 80, 160, 160, and 160 mg mannitol, resulting in a maximum cumulative dose of 635 mg
Methacholine
Methacholine consists of inhaling 0.0625 mg/mL, 0.25 mg/mL, 1 mg/mL, 4 mg/mL, and 16 mg/mL
Placebo
Placebo consists of inhaling humidified air
Rest
Exercise
Clinical Physiology Research Laboratory, Edmonton
University of Alberta
OTHER