A Study to Compare Tivozanib Hydrochloride to Sorafenib in Participants With Refractory Advanced Renal Cell Carcinoma (RCC)

PHASE3CompletedINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

May 24, 2016

Primary Completion Date

October 4, 2018

Study Completion Date

June 21, 2021

Conditions
Carcinoma, Renal Cell
Interventions
DRUG

Tivozanib hydrochloride

Tivozanib hydrochloride

DRUG

Sorafenib

Sorafenib

Trial Locations (191)

144

Regina Elena, Istituto Nazionale dei Tumori, IFO, IRCCS, Roma

151

Azienda Ospedaliera San Camillo Forlanini, Roma

1000

Institut Jules Bordet, Brussels

1032

Szent Margit Kórház, Budapest

1062

Magyar Honvédség Egészségügyi Központ, Budapest

1082

Semmelweis Egyetem, Budapest

1083

Semmelweis Egyetem, Budapest

1122

Országos Onkológiai Intézet, Budapest

1307

Universitätsklinikum Carl Gustav Carus, Dresden

2650

UZ Antwerpen, Edegem

2730

Herlev Hospital, Herlev

3500

Jessa Ziekenhuis - Campus Virga Jesse, Hasselt

3526

Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Miskolc

4032

Debreceni Egyetem Klinikai Központ, Debrecen

5000

Odense Universitetshospital, Odense

5100

Azienda Ospedaliera S. Maria di Terni, Terni

5530

CHU Dinant Godinne UCL Namur, Yvoir

5700

Békés Megyei Pándy Kálmán Kórház, Gyula

6000

Grand Hôpital de Charleroi - Site Notre-Dame, Charleroi

6720

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpo, Szeged

7000

CHU Ambroise Paré, Mons

7400

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár

7624

Pécsi Tudományegyetem Klinikai Központ, Pécs

7743

Jena University Hospital, Jena

8000

AZ Sint-Jan Brugge - Oostende - Campus Sint-Jan, Bruges

Aarhus Universitetshospital, Aarhus C

9000

UZ Gent, Ghent

10021

New York Presbyterian Hospital, New York

10032

Columbia University Medical Center - Herbert Irving Pavilion, New York

10060

Istituto di Candiolo, IRCCS, Candiolo

10467

Montefiore Medical Center, The Bronx

12065

New York Oncology Hematology, P.C., Clifton Park

12206

New York Oncology Hematology, P.C., Albany

12208

New York Oncology Hematology, PC, Albany

13273

Institut Paoli-Calmettes, Marseille

14004

H.U. Reina Sofía, Córdoba

14642

University of Rochester Medical Center, Rochester

15232

University of Pittsburgh Medical Center (UPMC), Pittsburgh

16132

IRCCS AOU San Martino-IST Istituto Nazionale per la Ricerca, Genova

17007

ICO-H.U.Dr.J.Trueta, Girona

18045

St. Luke University Health Network, Easton

19111

Fox Chase Cancer Center, Philadelphia

20007

MedStar Georgetown University Hospital, Washington D.C.

20089

Istituto Clinico Humanitas Rozzano, IRCCS, Rozzano

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20246

Universitätsklinikum Hamburg-Eppendorf, Hamburg

23007

C.H. de Jaén, Jaén

25123

AO Spedali Civili di Brescia, PO Spedali Civili, Brescia

26100

ASST-Istituti Ospitalieri di Cremona, AO di Cremona, Cremona

27100

IRCCS Policlinico San Matteo, Pavia

27157

Wake Forest University Baptist Medical Center (WFUBMC), Winston-Salem

28007

H.G.U. G. Marañón, Madrid

28031

H.U. Infanta Leonor, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

H.C. S.Carlos, Madrid

H.U. F. Jiménez Díaz, Madrid

28041

H.U. 12 de Octubre, Madrid

28046

H.U. La Paz, Madrid

28050

H. Madrid Norte Sanchinarro, Madrid

28222

H.U.P Hierro-Majadahonda, Majadahonda

28922

H.U.F. Alcorcón, Alcorcón

29010

H.U. Virgen de la Victoria, Málaga

30625

Medizinische Hochschule Hannover, Hanover

31008

C.H. de Navarra, Pamplona

33075

Hopital Saint-André, Bordeaux

33081

Centro di Riferimento Oncologico IRCCS, Aviano

33136

University of Miami Sylvester Comprehensive Cancer Center, Miami

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

33611

Evangelisches Krankenhaus Bielefeld, Bielefeld

35128

Istituto Oncologico Veneto IOV-IRCCS, Padua

37000

CHRU de Tours - Hopital Bretonneau TOURS, Tours

41009

H.U.V. Macarena, Seville

41124

AOU Policlinico di Modena, Modena

42271

Institut de Cancerologie de la Loire, Saint-Priest-en-Jarez

44195

Cleveland Clinic, Cleveland

44691

Wooster Specialty and Surgery Center, Wooster

44805

ICO, Saint-Herblain

44870

North Coast Cancer Care, Inc, Sandusky

44906

Ohio Cancer Specialists, Mansfield

46009

F.I. Valenciano de Oncología, Valencia

46026

H.U.P.La Fe, Valencia

46260

Investigative Clinical Research of Indiana, Indianapolis

47014

Irccs Irst, Meldola

48149

Universitaetsklinikum Muenster, Münster

48201

Karmanos Cancer Institute, Detroit

48202

Henry Ford Health System, Detroit

49000

Institut de Cancérologie de l'Ouest Site Paul Papin, Angers

50009

H.U. Miguel Servet, Zaragoza

50937

Uniklinik Köln Klinik und Poliklinik für Urologie, Cologne

52074

Universitätsklinikum Aachen, Aachen

52100

Ospedale S.Donato, AUSL 8 di Arezzo, Arezzo

53100

Usl 7 Siena - Ospedale Alta Valdelsa ASL TOSCANA SUD-EST, Poggibonsi

54519

Institut de cancérologie de Lorraine, Vandœuvre-lès-Nancy

59020

centre Oscar Lambret, Lille

60153

Loyola University Medical Center, Maywood

60590

Johann Wolfgang Goethe Universität, Frankfurt am Main

66013

P.O. Ss. Annunziata, Chieti

66421

Universitätsklinikum des Saarlandes, Homburg

68114

Nebraska Methodist Hospital, Omaha

68130

Midwest Cancer Center, Omaha

Urology Cancer Center, PC, Omaha

69120

Univesitaetsklinik Heidelberg, Heidelberg

71013

Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo

72000

Clinique Victor Hugo, Le Mans

72076

Universität Tübingen, Tübingen

73100

Ospedale Vito Fazzi, ASL Lecce, Lecce

75042

Texas Oncology-Garland, Garland

75093

Texas Oncology, P.A., Plano

75246

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

75601

Texas Oncology - Longview Cancer Center, Longview

75702

Texas Oncology - Tyler, Tyler

76104

Texas Oncology - Fort Worth 12th Ave, Fort Worth

76132

Texas Oncology SW Fort Worth Cancer Center, Fort Worth

76177

Arizona Oncology Associates, PC - HAL, Fort Worth

Comprehensive Cancer Centers of Nevada (CCCN), Fort Worth

Comprehensive Cancer Centers of Nevada, Fort Worth

Nebraska Cancer Specialists (NCS) - Midwest Cancer Center, Fort Worth

Texas Oncology - El Paso Cancer Treatment Center, Fort Worth

Texas Oncology-El Paso Cancer Treatment Center, Fort Worth

77030

Baylor College of Medicine - Baylor Clinic, Houston

78705

Texas Oncology - Austin Midtown, Austin

78731

Texas Oncology-Central Austin Cancer Center, Austin

78745

Texas Oncology - South Austin Cancer Center, Austin

79106

Universitätsklinikum Freiburg, Freiburg im Breisgau

80131

"IRCCS Fondazione Giovanni Pascale", Napoli

85004

University Of UA Cancer Center(UACC)/DH-SJHMC, Phoenix

85016

Arizona Oncology Associates, PC - HAL, Phoenix

85027

Arizona Oncology - Phoenix - Deer Valley Women's Center Loca, Phoenix

85258

Arizona Oncology - Scottsdale, Scottsdale

86021

Chu De Poitiers, Poitiers

89052

Comprehensive Cancer Center Of Nevada, Henderson

89074

Comprehensive Cancer Centers of Nevada, Henderson

89128

Comprehensive Cancer Center Of Nevada, Las Vegas

89148

Comprehensive Cancer Center of Nevada, Las Vegas

90095

UCLA, Los Angeles

91010

City of Hope Comprehensive Breast Cancer Center, Duarte

92637

Kliniken Nordoberpfalz AG, Klinikum Weiden, Weiden

92708

Long Beach Memorial Medical Center, Fountain Valley

94805

Institut Gustave Roussy, Villejuif

94904

Marin Cancer Care, Greenbrae

02215

Beth Israel Deaconess Medical Center, Boston

07601

Hackensack University Medical Center - John Theurer Cancer, Hackensack

V5Z 4E6

British Columbia Cancer Agency (BCCA), Vancouver

E1C 8X3

Dr. Leon Richard Oncology Centre, Moncton

N6A 4L6

London Health Sciences Center, London

M4N3M5

Sunnybrook, Toronto

656 53

Masarykuv onkologicky ustav, Brno

500 05

FN Hradec Kralove, Hradec Králové

779 00

Fakultni nemocnice Olomouc, Olomouc

656 91

Fakultni nemocnice u sv. Anny v Brne, Brno

150 06

Fakultni nemocnice v Motole, Prague

D-53127

SZB Study Center University Hospital Bonn, Bonn

H-1096

Egyesített Szent István és Szent László Kórház-Rendelőintéze, Budapest

H-9700

Markusovszky Egyetemi Oktatókórház, Szombathely

H-8900

Zala Megyei Korhaz, Zalaegerszeg

Unknown

AOU Careggi, Florence

Ieo, Irccs, Milan

00128

PU Campus Bio-medico di Roma, Roma

05-400

Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina, Otwock

02-781

Centrum Onkologii - Instytut im. Marii Sklodowskiej - Curie, Warsaw

04-125

MAGODENT Sp. z o.o. Szpital Onkologiczno-Kardiologiczny, Warsaw

36-200

Szpital Specjalist w Brzozowie Podkarpacki Ośrodek Onkologiczny, Brzozów

80-219

COPERNICUS Podmiot Leczn. Sp z o.o.,Wojew. Centrum Onkologii, Gdansk

31-216

NZOZ Vesalius Sp. z o.o., Krakow

50-556

Uniwersytecki Szpital Kliniczny im. J. Mikulicza-Radeckiego, Wroclaw

03203

H.G.U. de Elche, Elche

07010

H.U.Son Espases, Palma

08916

Institut Català d'Oncologia-Hospital Universitari Germans Trias i Pujol, Badalona

08907

Institut Catalá d´Oncología (I.C.O.), L'Hospitalet de Llobregat

08208

C.S. Parc Taulí, Sabadell

08003

H.del Mar, Barcelona

08025

H.Sta.Creu i St.Pau, Barcelona

08035

H.U.Vall d'Hebrón, Barcelona

08036

H. Clinic de Barcelona, Barcelona

CB2 0QQ

Addenbrooke's Hospital, Cambridge

G12 0YN

Beatson West Of Scotland Cancer Centre, Glasgow

GL53 7AN

Cheltenham General Hospital, Cheltenham

SO16 6YD

Southampton University Hospitals Nhs Trust, Southampton

BB2 3HH

East Lancashire Hospitals NHS Trust, Blackburn

PR2 9HT

Lancashire Teaching Hospitals NHS Foundation Trust, Preston

ST4 6QG

Royal Stroke Center, Stoke-on-Trent

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

LS9 7TF

St James's University Hospital / Leeds Teaching Hospitals, Leeds

SW36JJ

The Royal Marsden NHS Foundation Trust, London

W6 8RF

Charing Cross Hospital, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

HA6 2RN

Mount Vernon Cancer Care, Middlesex

NG5 1PB

Nottingham University Hospitals NHS Trust - City Hospital, Nottingham

OX3 7LJ

Churchill Hospital [Oncology], Oxford

SA2 8QA

Singleton Hospital, Swansea

WV10 0QP

New Cross Hospital, Wolverhampton

Sponsors
All Listed Sponsors
lead

AVEO Pharmaceuticals, Inc.

INDUSTRY